Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report

Qiao, Zhenguo; Chen, Yi; Shi, Wangtianyi; Yang, Jun; Song, Yi; Shen, Jiaqing

doi:10.1177/0300060520904849

Cited by 5 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed medical and family history of the patient usually provides helpful clues in making the diagnosis. Patients who have experienced frequent bleeding during infancy or childhood, as was the case with our patients, should be given special consideration for GT [3]. Furthermore, a thorough physical examination of patients with GT frequently reveals ancient skin ecchymosis.…”

Section: Discussionmentioning

confidence: 65%

“…For an evaluation of GT, laboratory tests are necessary. In individuals with this disease, platelet structure and count are usually within normal limits, but the bleeding time is much greater [3]. Consequently, the confirmation of GT is based on the recognition of abnormalities in platelet aggregation, and it is crucial to use more precise techniques, such as flow cytometry or gene detection, to make a definitive diagnosis [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Salih,

Ihtisham,

Ullah

et al. 2023

ICMR

View full text Add to dashboard Cite

A rarely seen bleeding illness called Glanzmann's thrombasthenia (GT) is inherited via the autosomal recessive gene. Platelet membrane glycoprotein IIb/IIIa (integrin aIIbb3) structural abnormalities and malfunction play a major role in the development of GT. The most prevalent signs of GT are various types of bleeding, including menorrhagia in females, recurrent nasal bleeding, mucocutaneous bleeding, and continuous bleeding after injury or surgery. Some patients may not survive after undergoing such a hemorrhage. It is unusual for GT to experience spontaneous upper and lower gastrointestinal hemorrhages. In this case study, a young boy with accidental bleeding in vomitus and fresh blood in his stool was hospitalized. His primary GT is an uncommon autosomal recessive genetic condition characterized by dysfunctional platelet aggregation symptoms that were sporadic and recurring chronic fresh blood in his stool. Blood dripped from the stomach body wall during the gastroscopy. However, except for petechiae no visible lesions were discovered, like erosion or ulceration. Further investigations revealed that the patient's BT and CT were prolonged and platelet aggregation was poor. After receiving aggressive treatment, the patient showed clinical improvement and was eventually diagnosed with GT.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Salih,

Ihtisham,

Ullah

et al. 2023

ICMR

View full text Add to dashboard Cite

show abstract

“…144 In patients with GIB, digestive endoscopy examination is needed to exclude such other causes of hemorrhage as peptic ulcers. 145…”

Section: Common Congenital Bleeding Disordersmentioning

confidence: 99%

“…144 In patients with GIB, digestive endoscopy examination is needed to exclude such other causes of hemorrhage as peptic ulcers. 145 In patients who are refractory due to repeated platelet transfusion, rFVIIa can reduce the effects of hemorrhage. 146 Antifibrinolytics, alone or in combination, can be useful.…”

Section: Gib In Glanzmann Thrombastheniamentioning

confidence: 99%

Gastrointestinal Bleeding in Congenital Bleeding Disorders

Samii

Norouzi

Ahmadi

et al. 2022

Semin Thromb Hemost

View full text Add to dashboard Cite

Gastrointestinal bleeding (GIB) is serious, intractable, and potentially life-threatening condition. There is considerable heterogeneity in GIB phenotypes among congenital bleeding disorders (CBDs), making GIB difficult to manage. Although GIB is rarely encountered in CBDs, its severity in some patients makes the need for a comprehensive and precise assessment of underlying factors and management approaches imperative. Initial evaluation of GIB begins with assessment of hematological status; GIB should be ruled out in patients with chronic anemia, and in presentations that include hematemesis, hematochezia, or melena. High-risk patients with recurrent GIB require urgent interventions such as replacement therapy for treatment of coagulation factor deficiency (CFD). However, the best management strategy for CFD-related bleeding remains controversial. While several investigations have identified CBDs as potential risk factors for GIB, research has focused on assessing the risks for individual factor deficiencies and other CBDs. This review highlights recent findings on the prevalence, management strategies, and alternative therapies of GIB related to CFDs, and platelet disorders.

show abstract

“…Gastrointestinal bleeding (GIB) may occur in 10-20%, commonly due to trauma such as surgery. Spontaneous GIB is rare and has only been seen in patients with an underlying gastrointestinal disease such as gastroduodenal ulcers or infections by Helicobacter pylori [2]. Some cases of GIB associated with gastrointestinal angiodysplasia (GIADs) have been also described [3].…”

Section: Introductionmentioning

confidence: 99%

Glanzmann's thrombasthenia associated with gastrointestinal angiodysplasias successfully treated with bevacizumab

Saladino,

Gonzalez,

Chuliber

et al. 2023

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

Glanzmann's Thrombasthenia (GT) is a rare hemorrhagic condition caused by a platelet surface receptor disorder of the glycoprotein (GP) IIb/IIIa. Symptoms of GT are various forms of hemorrhages, such as purpura, epistaxis and menorrhagia. Gastrointestinal bleeding (GIB) is a rare expression of the condition and may occur due to traumas in the GI tract or as a consequence of gastrointestinal angiodysplasia (GIADs). In this case report, we present a middle-aged woman with recurrent GIB consequent to GIADs with persistent melena and iron deficiency anemia. After several unsuccessful therapeutic interventions, the patient was studied by the hereditary hemorrhagic telangiectasia's (HHT – Osler–Weber–Rendu disease) unit, where she received bevacizumab, showing a complete improvement in symptoms as well as a reduction in her GIADs. This case shows that bevacizumab could be a possible line of treatment for patients with coagulation disorders with GIADs.

show abstract

Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report

Cited by 5 publications

References 17 publications

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Gastrointestinal Bleeding in Congenital Bleeding Disorders

Glanzmann's thrombasthenia associated with gastrointestinal angiodysplasias successfully treated with bevacizumab

Contact Info

Product

Resources

About