Mammalian response to subdermal implantation of textured microimplants

Beisang, Arthur; Ersek, Robert A.

doi:10.1007/bf00455154

Cited by 53 publications

(28 citation statements)

References 7 publications

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“…[27][28][29][30][31] Further studies are clearly needed to assess the material's safety. In the literature there are few reports of histologic analyses after silicone injection into the vocal cord; 32 most of the studies of this type are in the field of urology.…”

Section: Discussionmentioning

confidence: 99%

Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: Histologic evaluation in a rabbit model

et al. 2003

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The objective is to study the tissue reaction of the paralyzed vocal cord in response to the injection of particulate plastics in a rabbit model. Forty-five New Zealand rabbits with surgical vocal-fold paralysis were used in the study. Histologic reactions of the larynx and the regional lymph nodes were analyzed by a single blinded pathologist at 6 weeks and 6 months after a vocal-cord injection of Teflon or of silicone elastomer. Macroscopic studies of the liver, lungs, spleen, kidney, and brain were performed. The histological study showed a greater proportion of chronic granulomatous inflammation in animals injected with silicone than in those injected with Teflon. The immunohistochemical study showed a higher degree of phagocytosis of Teflon particles than of the silicone particles. The silicone group presented a more severe fibrous reaction than the Teflon group, but the difference was not significant. No migration particles were found. It is concluded that silicone, having a greater viscosity than Teflon because of the size of its particles, induces more fibrosis and a larger proportion of foreign giant cells in the host. Due to this histological reaction, silicone particles present greater anchorage and stability.

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Section: Discussionmentioning

confidence: 99%

Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: Histologic evaluation in a rabbit model

et al. 2003

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“…The pad former was treated successfully using CISC for 24 h and the latter by the administration of a spasmolytic for weight was estimated when patients changed their pads; the mean weight was 117 g. All patients required at several days. material in cardiac pacemakers, and carries no risk of Discussion cancer because these silicone particles diCer from the liquid silicone used in implants [25]. Incontinence after RP is a major complication for some patients; despite the increasing frequency of this operInjection therapy has been used for many years to treat post-operative incontinence; Politano [10] used ation, there has been no increase in the incontinence rate.…”

Section: Resultsmentioning

confidence: 99%

“…Implantation of PDS in the carotid artery of a sheep and using a nephroscope with a video unit, under regional or general anaesthesia. The nephroscope oCers the subsequent migration to the brain caused no demyelination and only a mild inflammatory reaction [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

The use of polydimethylsiloxane in the treatment of incontinence after radical prostatectomy

Colombo

Augustin

Breinl

et al. 1997

British Journal of Urology

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Objective To report the results of transurethral submu-Results After a mean follow-up of 15.5 months, five patients, who suCered from day and night inconticosal injection therapy of polydimethylsiloxane (PDS) to treat incontinence after radical prostatectomy (RP).nence and required at least five pads per day, were dry after injection therapy. One patient improved Patients and methods Since 1993, about 80 retropubic RPs have been carried out at our institution each significantly but still required two pads during the day, but was continent during the night; three patients year. Severe post-operative incontinence occurred in six patients, with a mean duration of incontinence required a second injection. A mean of 7.5 mL of PDS was used per patient and the side-eCects of therapy after RP of 28 months. The pre-operative evaluation consisted of cysto-urethroscopy and urodynamics.(dysuria and urinary retention) were minimal. Conclusion Because PDS has excellent biocompatibility, Because we have no experience with artificial sphincter implantation, transurethral injection therapy was few side-eCects or complications, transurethral injection therapy using silicone particles is a justifiable used to treat the post-operative incontinence, using PDS (vulcanized silicone rubber particles). This mateprocedure for treating incontinence after RP. Keywords Radical prostatectomy, post-operative inconrial has a mean particle size of 188 mm, providing stability of the material at the injection site. The six tinence, transurethral submucosal injection, polydimethylsiloxane patients with severe post-operative incontinence were treated using injection therapy with PDS. various materials, e.g. PTFE, collagen, fat or silicone

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“…24 Macroplastique 1 is an elastomer composed of solid particles and is more inert than silicone gel, causing a mild acute in¯ammatory reaction that decreases 2 ± 4 weeks after injection. 25 There is no convincing evidence that such elastomers are associated with connective tissue disease. 26 In our experience endoscopic injection of Macroplastique 1 produced an excellent result (77% with complete resolution and a further 9% with downgrading of re¯ux) in treating VUR in adult neuropathic bladders.…”

Section: Discussionmentioning

confidence: 99%

Vesico-ureteric reflux in adults with neuropathic bladders treated with Polydimethylsiloxane (Macroplastique®)

Shah

Kabir²,

Lane³

et al. 2001

Spinal Cord

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Objective: To establish the ecacy of Macroplastique 1 in treating vesico-ureteric re¯ux (VUR) in adults with neuropathic bladder dysfunction. Patients and methods: Fifteen patients (12 male and three female), age range 19 to 80 years (mean age 38) were included in this study. Diagnosis was con®rmed by videourodynamics. In seven patients re¯ux was present bilaterally. Twenty-two re¯uxing ureters were treated. Twelve patients had detrusor hyper-re¯exia, two had are¯exic bladders and one had loss of bladder wall compliance. According to the International Grading System, 10 ureters had grade IV re¯ux, ®ve had grade III re¯ux, ®ve had grade II re¯ux, and two had grade I re¯ux. Macroplastique 1 (0.5 ± 1.5 ml) was injected submucosally under each ureteric ori®ce to convert the opening to a slit like shape. The patients were followed up from 9 to 68 months. Results: VUR was completely resolved in 72.7% (16) ureters following a single injection and in a further 4.5% (1) ureter following a second injection. 9.1% (2) ureters were improved and treatment failed in 13.7% (3) ureters. Two patients showed a recurrence of re¯ux 1 and 4 years after primary injection and subsequently had a curative second injection. Most of the patients in whom VUR was cured or improved showed a reduction in laboratory proven urinary infection rates. Conclusion: Macroplastique 1 produced an excellent result (86% with complete resolution or improvement of re¯ux) in treating VUR in adult neuropathic bladders. This is comparable to larger studies carried out on the paediatric population. This is an easy procedure, which avoids major surgery and can be performed as a day case. In cases of failure or recurrence, repeat injection or open surgery can be undertaken without any added complications. Spinal Cord (2001) 39, 92 ± 96

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Mammalian response to subdermal implantation of textured microimplants

Cited by 53 publications

References 7 publications

Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: Histologic evaluation in a rabbit model

Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: Histologic evaluation in a rabbit model

The use of polydimethylsiloxane in the treatment of incontinence after radical prostatectomy

Vesico-ureteric reflux in adults with neuropathic bladders treated with Polydimethylsiloxane (Macroplastique®)

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