Maltese cross-like crystals in the urinary sediment of a diabetic patient

Etter, Christoph; Russi, Ruth; Fogazzi, Giovanni B.; Wüthrich, Rudolf P.; Serra, Andreas L.

doi:10.1093/ndtplus/sfp062

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Hyperlipiduria1

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2014

2024

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Cited by 4 publications

(3 citation statements)

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“…Birefringent Maltese cross pattern as seen under polarized light microscopy represent either lipid particles, DHA crystals, or starch (latex gloves). [ 4 ] Thus, the diagnosis of APRT deficiency cannot be based solely on stone analysis or identification of DHA crystals. Blood genetic testing has to be done to confirm the APRT deficiency.…”

Section: Discussionmentioning

confidence: 99%

Dihydroxyadenine stone with adenine phosphoribosyltransferase deficiency: A case report

Krishnappa¹,

Krishnamoorthy²,

Gowda³

2017

Indian J Urol

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Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive error of purine metabolism resulting in the generation of 2,8-dihydroxyadenine (DHA), a highly insoluble metabolite of adenine, which can cause radiolucent urolithiasis. This is the second case of DHA stone being reported in India and the first case in India to document the mutation of the APRT gene on blood DNA analysis.

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Section: Discussionmentioning

confidence: 99%

Dihydroxyadenine stone with adenine phosphoribosyltransferase deficiency: A case report

Krishnappa¹,

Krishnamoorthy²,

Gowda³

2017

Indian J Urol

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“…20,21 In urine, lipid, leucine, starch, and 2,8-dihydroxyadenine crystals may also show Maltese crosses. [22][23][24] …”

Section: Discussionmentioning

confidence: 99%

Triamterene Crystalline Nephropathy

Nasr

Milliner

Wooldridge

et al. 2014

American Journal of Kidney Diseases

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“…It is important to note that a number of artifacts can lead to this birefringent appearance, the most common of which is the starch molecule (often found in contamination during handling of urinary specimens via latex glove use). Lipiduria can be distinguished from this artifact on the basis that starch molecules have an irregular appearance whereas true cholesterol will have symmetrical arms of the "Maltese-Cross" configuration (Etter et al 2009).…”

Section: Hyperlipiduriamentioning

confidence: 99%