Triamterene Crystalline Nephropathy

Nasr, Samih H.; Milliner, Dawn S.; Wooldridge, Thomas D.; Sethi, Sanjeev

doi:10.1053/j.ajkd.2013.06.023

Cited by 19 publications

(10 citation statements)

References 25 publications

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“…The dysproteinemia-related CN includes light chain cast nephropathy, also known as myeloma cast nephropathy, which is the most common dysproteinemia-related renal disease [53,54]. Crystalline nephropathy may develop during the use of drugs (ceftriaxone [55]), sulfadiazine [56], acyclovir [57], triamterene [58], atanazavir [59], and others that are excreted by the kidney (see details in recent review [60]). Calcium crystals CN is characterized by abundant tubular and interstitial deposits of calcium phosphate or CaOx crystals, easily distinguished by their tinctorial properties.…”

Section: Determinants Of Randall's Plaque Formationmentioning

confidence: 99%

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

et al. 2019

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A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts in the field from Europe and the United States interacted closely during the symposium which promoted a chance to explore new frontiers in the field of kidney stone disease. This manuscript summarizes some of the major highlights of the meeting.

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Section: Determinants Of Randall's Plaque Formationmentioning

confidence: 99%

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

et al. 2019

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“…It was not until 2014 when another 2 cases of triamterene-associated AKI were reported, one of which was originally misdiagnosed as 2,8-DHA crystal deposition due to APRT deficiency. 13 …”

Section: Discussionmentioning

confidence: 99%

Raman Spectroscopy for the Diagnosis of Intratubular Triamterene Crystallization

Sperati

Zhang

Delsante

et al. 2018

Kidney International Reports

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“…S4). For two conditions involving cisplatin and triamterene, KM5 was activated but did not show fibrotic histopathology even though cisplatin is known to induce kidney fibrosis (Yuasa et al, 2014) whereas triamterene is an acute nephrotoxicant known to cause nephropathy (Nasr et al, 2014).…”

Section: Correlated Prediction Of Histopathology With Module Activationmentioning

confidence: 98%

Systems toxicology of chemically induced liver and kidney injuries: histopathology‐associated gene co‐expression modules

AbdulHameed

Wallqvist

2016

J of Applied Toxicology

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Organ injuries caused by environmental chemical exposures or use of pharmaceutical drugs pose a serious health risk that may be difficult to assess because of a lack of non‐invasive diagnostic tests. Mapping chemical injuries to organ‐specific histopathology outcomes via biomarkers will provide a foundation for designing precise and robust diagnostic tests. We identified co‐expressed genes (modules) specific to injury endpoints using the Open Toxicogenomics Project‐Genomics Assisted Toxicity Evaluation System (TG‐GATEs) – a toxicogenomics database containing organ‐specific gene expression data matched to dose‐ and time‐dependent chemical exposures and adverse histopathology assessments in Sprague–Dawley rats. We proposed a protocol for selecting gene modules associated with chemical‐induced injuries that classify 11 liver and eight kidney histopathology endpoints based on dose‐dependent activation of the identified modules. We showed that the activation of the modules for a particular chemical exposure condition, i.e., chemical‐time‐dose combination, correlated with the severity of histopathological damage in a dose‐dependent manner. Furthermore, the modules could distinguish different types of injuries caused by chemical exposures as well as determine whether the injury module activation was specific to the tissue of origin (liver and kidney). The generated modules provide a link between toxic chemical exposures, different molecular initiating events among underlying molecular pathways and resultant organ damage. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Journal of Applied Toxicology published by John Wiley & Sons, Ltd.

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Triamterene Crystalline Nephropathy

Cited by 19 publications

References 25 publications

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

Raman Spectroscopy for the Diagnosis of Intratubular Triamterene Crystallization

Systems toxicology of chemically induced liver and kidney injuries: histopathology‐associated gene co‐expression modules

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