Malignant transformation of a spiradenoma with blaschkoïd pattern

Abstract

Key Clinical MessageEccrine spiradenoma is a benign and rare adnexal tumor originating from cutaneous eccrine sweat glands. It usually presents as a solitary lesion. It can have different presentations, including a blaschkoid arrangement which is rare. Malignant transformation is possible and usually occurs after a long period of latency in multifocal types.

Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review

“…Moreover, several studies have reported multiple nodules (11) or a linear zosteriform pattern (12)(13)(14). The typical clinical manifestation of MES is malignant transformation from a long-standing benign ES lesion with recent rapid growth, color change, erythema, ulceration, new-onset pain and bleeding (1,(15)(16)(17)(18)(19)(20).…”

Multiple eccrine spiradenoma in a young Greek patient: case report and review of the literature

“…ES is an uncommon, benign adnexal tumor characterized by one or more nodules. The tumor has been described as " blue ball in the dermis " because of its blue color, although it might be purple, red, pink or gray [3]. Few clinical variants have been described like solitary ES which is generally accepted as the most common, multiple ES and giant vascular ES.…”

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

“…Spiradenomas are well-differentiated, benign, and dermal neoplasms that arise from the hair follicle bulge rather than the eccrine sweat gland, based on an immunohistochemical study of stem cell markers and with CD200 [ 248 ]. The pathogenesis is not entirely understood, but a defect in the tumor suppressor gene, CYLD , is thought to contribute to their development in Brooke-Spiegler syndrome, which also features multiple spiradenomas [ 249 ].…”