The diagnosis remains probable despite the strong temporal relationship because after literature review with the keywords 'SARS-CoV-2', 'Vaccine', 'COVID-19', 'Angiomatosis', 'Haemangiomatosis', 'Cherry' and/or 'Angiomas', no other articles describe true eruptive angiomas after any SARS-CoV-2 vaccine.The pathogenesis of this skin disorder remains unclear. Among the various possibilities, we proposed an HVV-8 reactivation elicited by the vaccination, 1,5 but a real-time PCR requested to search for herpesvirus DNA on cutaneous samples resulted negative.Cells exposing angiotensin-converting enzyme 2 (ACE2) could be altered by circulating spike proteins, probably affecting the ACE2 pathway. 6 Inflammation or increased angiotensin II levels could stimulate the proliferation of predisposed endothelial cells of the skin, causing angiomas; the latter mechanism is also proposed in infantile haemangiomas. 7 Still, experimental studies have not shown significant alterations in the angiotensin II pathway in patients with COVID-19. 8 We believe in a dysregulation of the neuropilin-1 (NRP-1) proteins cascade 9 as a plausible mechanism. Spike protein portions could bind to the NRP-1 and interfere with the VEFG-R, which has been already described to cause cherry angiomas proliferation when dysregulated. This interaction could recall the side effects produced by ramucirumab and other VEGF-R inhibitors. 10 In conclusion, in this case report, we aimed to raise awareness of the increasing variety and complexity of viral, paraviral and vaccine skin reactions induced by the immune response to the genetic material related to the SARS-CoV-2. By sharing this case, we hope that physicians can be aware of the increasing spectrum of AEDs related to these vaccines skin manifestations, however harmless and self-limiting.

Kyphoplasty (KP) and vertebroplasty (VP) have been successfully employed for many years for the treatment of osteoporotic vertebral fractures. The purpose of this review is to resolve the controversial issues raised by the two randomized trials that claimed no difference between VP and SHAM procedure. In particular we compare nonsurgical management (NSM) and KP and VP, in terms of clinical parameters (pain, disability, quality of life, and new fractures), cost-effectiveness, radiological variables (kyphosis correction and vertebral height restoration), and VP versus KP for cement extravasation and complications profile. Cement types and optimal filling are analyzed and technological innovations are presented. Finally unipedicular/bipedicular techniques are compared. Conclusion. VP and KP are superior to NSM in clinical and radiological parameters and probably more cost-effective. KP is superior to VP in sagittal balance improvement and cement leaking. Complications are rare but serious adverse events have been described, so caution should be exerted. Unilateral procedures should be pursued whenever feasible. Upcoming randomized trials (CEEP, OSTEO-6, STIC-2, and VERTOS IV) will provide the missing link.

Our results support the opinion that the association between psoriasis and MF does exist. It is most possibly related to the chronic lymphocyte stimulation that occurs during psoriasis that eventually leads to a dominant clone and the evolution to CTCL. Our study suggests that apart from cases of early MF, which are being indeed misdiagnosed as psoriasis, there is another group of patients, where psoriasis truly coexists with - or even progresses to - MF.

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