Multiple eccrine spiradenoma in a young Greek patient: case report and review of the literature

Abstract

Eccrine spiradenoma is an uncommon and benign adnexal tumor characterized by one or more nodules. The present article refers to a young patient with multiple and gradually enlarged nodules which remained undiagnosed and untreated for many years. Lesions were initially considered as multiple leiomyomas whereas skin biopsy revealed the existence of uncommon and benign tumors of eccrine and apocrine grandular adnexa confirming the diagnosis of eccrine spiradenoma. Similarities in clinical appearance and symptoms between tumors may lead to erroneous diagnosis and skin biopsy is an essential tool for differential diagnosis.

A case of eccrine spiradenoma presenting as a painless, reddish nodule on the forearm

“…However, uncommon sites have been reported, such as the ears, eyelids, lips, and hands [4]. Paroxysmal pain and tenderness are the main features of the tumor, observed in 91% of cases [1,5]. Our patient accumulated numerous misleading clinical features, notably, the location in the anterior aspect of the forearm, the reddish color of the tumor, its painless nature, the presence of ulceration, and a peripheral collar.…”

“…Eccrine spiradenoma (ES) presents mostly (97%) as a solitary nodule and, rarely, as multiple [1], linear, Blaschkoid, or grouped lesions [2]. The tumor arises from the intradermal part of the duct of eccrine sweat glands [3].…”

A cocktail of usual and unusual presentation of cutaneous tumors – A case series

“…10 Paroxysmal pain and tenderness are the main features of the tumor, observed in 91% of cases. 11,12 They may be associated with multiple trichoepitheliomas and cylindromas and less frequently, trichoblastoma, and cutaneous lymphadenoma (adamantinoid trichoblastoma) as part of the morphological spectrum of the Brooke-Spiegler syndrome. 13 The proliferating trichilemmal cyst (pilar tumor of the scalp) is a rare, usually benign tumor of external root sheath derivation and mostly appears to develop within the wall of a pre-existent pilar cyst.…”