Malignant potential of intraductal papillary mucinous neoplasms of the pancreas

Nakajima, Yoshiyuki; Yamada, Takatsugu; Sho, Masayuki

doi:10.1007/s00595-009-4227-y

Cited by 8 publications

(5 citation statements)

References 88 publications

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“…13 The malignancy potential is higher in MD-IPMN cases (57% -92%) than in those with BD-IPMN (6% -46%). 14 Based on the morphological characteristics and immunohistochemical features of mucin glycoproteins, IPMN is also classified into four subtypes: gastric, intestinal, pancreatobiliary and oncocytic. 12 The most frequent are gastric and intestinal subtypes.…”

Section: Discussionmentioning

confidence: 99%

New-onset diabetes as clinical presentation of invasive intraductal papillary mucinous neoplasm of the pancreas

Sousa¹,

Seara²,

Duarte³

et al. 2020

Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

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Mulher de 59 anos com perda ponderal signifi cativa, polidipsia e poliúria com poucos meses de evolução, tendo sido diagnosticado diabetes inaugural (HbA1C:14,9%). Por dor abdominal recorrente, realizou tomografi a computorizada abdomino-pélvica que revelou ducto pancreático principal dilatado (>10 mm) ocupado por estrutura hipodensa-suspeita de neoplasia mucinosa papilar intraductal. Adicionalmente, foi documentada carcinomatose peritoneal, assim como dois nódulos hepáticos em que a análise citológica revelou metástase de carcinoma mucosecretor. A concentração sérica do CA 19.9 era 70 vezes acima do limite superior do normal. A doente foi proposta para quimioterapia paliativa e faleceu 4 meses após o diagnóstico de diabetes. A diabetes inaugural no adulto pode ser uma manifestação inicial de cancro pancreático. A neoplasia mucinosa papilar intraductal tem potencial maligno podendo progredir para carcinoma invasivo. A presença de diabetes inaugural está associada a esta progressão maligna. É essencial o desenvolvimento de ferramentas clínicas que identifi quem os doentes com diabetes inaugural que possam benefi ciar do rastreio de cancro pancreático.

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Section: Discussionmentioning

confidence: 99%

New-onset diabetes as clinical presentation of invasive intraductal papillary mucinous neoplasm of the pancreas

Sousa¹,

Seara²,

Duarte³

et al. 2020

Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

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“…IPMN of the pancreas is defined as an intraductal mucinproducing neoplasm of the pancreatic duct, and the cases are subdivided into main duct-type and branch duct-type IPMN depending on the location of the lesion [25][26][27]. Histologically, it is classified as adenoma (dysplasia of low grade), borderline (dysplasia of moderate degree), carcinoma in situ and infiltrating carcinoma.…”

Section: Discussionmentioning

confidence: 99%

A one-stage operation for abdominal aortic aneurysm and intraductal papillary mucinous neoplasms of the pancreas: report of a case

Tsuji¹,

Kitano²,

Sawada³

2012

Surg Today

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Pancreatic surgery concomitant with abdominal aortic repair is rarely chosen due to concerns about prosthetic infection following pancreatic leakage and the poor prognosis of pancreatic neoplasms. We herein report a successfully treated case of infrarenal abdominal aortic aneurysm and intraductal papillary mucinous neoplasms of the pancreas treated by a one-stage operation. A 75-year-old male with a history of cerebral infarction and chronic subdural hematoma was referred to our department with a pulsatile abdominal mass. A 70-mm infrarenal abdominal aortic aneurysm with severe proximal neck angulation and a 28-mm multilocular cystic tumor with mural nodules in the pancreas body were detected. Abdominal aortic repair with a prosthetic graft and distal pancreatectomy were performed simultaneously. The postoperative course was mostly uneventful, and he was discharged to a rehabilitation facility.

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“… 2 , 3 , 8 The incidence of EPMs among patients with IPMN ranges from 10% to 52% according to previous studies. 2 – 4 , 6 , 9 – 14 Gastric cancer 2 , 3 , 5 , 6 , 15 and colorectal cancer (CRC) 2 – 7 , 14 , 15 are the most common EPMs in patients with IPMN cysts.…”

Section: Introductionmentioning

confidence: 99%

Increased prevalence of colorectal neoplasia in patients with intraductal papillary mucinous neoplasms

Yovel

Bear

Scapa

et al. 2022

Therap Adv Gastroenterol

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Background: The association between intraductal papillary mucinous neoplasms (IPMNs) and colorectal cancer (CRC) and polyps is controversial. Objectives: To compare the prevalence of CRC and colorectal polyps among patients with IPMN and matched average risk individuals. Methods: A match cross-sectional historical study comparing colonoscopy findings of 310 patients with IPMN cysts who underwent at least one colonoscopy examination from 2004 through 2019, with 310 age- and gender-matched average risk participants who underwent a screening colonoscopy. CRC and polyps were assessed in both groups. The prevalence and odds ratio were calculated. Results: CRC was diagnosed in 16 of 310 patients with IPMN (5.2%), and at least one polyp was detected in 96 patients (31%). The prevalence of CRC was greater among patients with IPMN than in matched individuals [5.2% versus 1.3%, p = 0.012, prevalence odds ratio (POR) 4, confidence interval (CI) 1.29–16.44]. The overall prevalence of polyps was not higher among patients with IPMN than in matched individuals (31% versus 26.8%, p = 0.291, POR 1.22, CI 0.85–1.76). However, the prevalence of colorectal adenomas with high-grade dysplasia was higher in patients with IPMN than in matched individuals (4.2% versus 1%, p = 0.02, POR 4.33, CI, 1.19–23.7). The prevalence of large polyps (i.e. more than 20 mm in size) was also greater in patients with IPMN than in matched individuals (6.1% versus 1.9%, p = 0.011, POR 3.6, CI, 1.29–12.40). Conclusion: Patients with IPMN have a significantly higher prevalence of CRC and advanced polyps than the average risk population. In view of our findings, we suggest that once the diagnosis of IPMN is made, special consideration of CRC should be undertaken.

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Malignant potential of intraductal papillary mucinous neoplasms of the pancreas

Cited by 8 publications

References 88 publications

New-onset diabetes as clinical presentation of invasive intraductal papillary mucinous neoplasm of the pancreas

New-onset diabetes as clinical presentation of invasive intraductal papillary mucinous neoplasm of the pancreas

A one-stage operation for abdominal aortic aneurysm and intraductal papillary mucinous neoplasms of the pancreas: report of a case

Increased prevalence of colorectal neoplasia in patients with intraductal papillary mucinous neoplasms

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