Malignant pleural mesothelioma: clinicopathologic and survival characteristics in a consecutive series of 394 patients☆

Borasio, P.; Berruti, Alfredo; Billè, Andrea; Lausi, Paolo Olivo; Levra, Matteo Giaj; Giardino, Roberto; Ardissone, Francesco

doi:10.1016/j.ejcts.2007.09.044

Cited by 88 publications

(72 citation statements)

References 22 publications

(27 reference statements)

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“…According to Borasio et al significant predictors of survival include performance status, platelet count, histology and degree of involvement of pleural cavity. [1] According to Yan TD et al asbestos exposure, negative lymph node involvement and receipt of adjuvant radiation were associated with improved survival. [20] Flores et al reported that standard uptake value greater than 10, mixed histology and stages III and IV are poor risk factors in malignant pleural mesothelioma.…”

Section: Disclosure Statementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[1,2] As it has a highly aggressive behavior, there have been some studies to identify more accurate prognostic factors and staging systems, and to investigate novel treatment regimens. [1] However, the relative rarity of this neoplasm has limited research opportunities, and only a few clinical trials have been done or are on-going. [2] In this retrospective study, we reported the single institutional 7 years experience of the clinicopathologic and therapeutic characteristics and the factors affecting survival and the factors that individually predicted better prognosis in patients with MPM.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Gul¹

2017

TJ Oncol

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OBJECTIVEA single-institution study of 7 years of experience was performed to investigate the clinicopathological and therapeutic characteristics of malignant pleural mesothelioma (MPM) patients who received multimodality treatment, as well as factors affecting survival. METHODSA retrospective review of a consecutive cohort of pathologically confirmed MPM patients who were referred to our radiation oncology clinic and received multimodality treatment strategy that included surgery, chemotherapy, and radiotherapy at our training and research hospital between 2001 and 2008 was performed. RESULTSA total of 53 patients were included in the study. Median age was 58 years (range: 33-79 years). Mean duration of follow-up was 14 months (range: 4-82 months). Disease-free status and overall survival were 11 months (range: 3-50 months) and 14 months (range: 4-82 months), respectively. Factors that individually predicted better prognosis were younger age (<50 years), having undergone surgery, having received radiotherapy, and having undergone multimodality treatment. CONCLUSIONFurther comprehensive and randomized studies are required to better understand biological behavior of MPM in order to obtain more successful results in the management of the disease.

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Section: Disclosure Statementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Gul¹

2017

TJ Oncol

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“…A literature review evaluating reports in the last 10 years of outcomes after pleurectomy decortication demonstrates a median survival between 10 and 25 months (Table 1) (2,5,9,12,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Thirty-day mortality was between 0.0-6.8% across all studies.…”

Section: Discussionmentioning

confidence: 98%

Pleurectomy and decortication

Vlahu

Vigneswaran

2017

Ann. Transl. Med.

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Pleurectomy and decortication (P/D) improve survival and quality of life in selected patients with malignant pleural mesothelioma. The operative procedure was not standardized until recently. The goal of the operation is to perform a macroscopic complete resection of the tumor. This often involves resection of the parietal and visceral pleura and invariably a partial or complete resection and prosthetic reconstruction of ipsilateral hemidiaphragm. We describe our operative planning and technique as well as outcomes of P/D reported in current literature.

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“…Generally, the prognosis for malignant mesothelioma remains disappointing, although there have been some modest improvement in prognosis from newer chemotherapies and multimodality treatment (Borasio et al, 2008). Treatment of malignant mesothelioma at earlier stages has a better prognosis, but cures are exceedingly rare (Borasio et al, 2008). Histological subtype, patient's age and health status are important prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

Malignant pleural mesothelioma treated as pulmonary tuberculosis

Aiyekomogbon¹,

Chom²,

Tabari³

et al. 2016

Int. J. Med. Med. Sci.

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A 45 year old man with malignant pleural mesothelioma had symptoms of prolonged cough, heamoptysis, breathlessness, weight loss and low grade persistent fever. The high prevalence of pulmonary tuberculosis in this environment, coupled with paucity of radiologists in rural areas to competently review his chest radiograph, resulted in making the wrong diagnosis of pulmonary tuberculosis (PTB) as against malignant pleural mesothelioma. He was also wrongly treated for PTB for a period of nine months before referral to a Teaching Hospital. The correct diagnosis was made in a university teaching hospital where adequate specialized manpower was available. Distant metastasis to the liver was already observed at presentation. He was treated with six courses of chemotherapy (Peclitaxel and Cisplastin) and he did well before he was lost to follow-up.

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Malignant pleural mesothelioma: clinicopathologic and survival characteristics in a consecutive series of 394 patients☆

Cited by 88 publications

References 22 publications

Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Pleurectomy and decortication

Malignant pleural mesothelioma treated as pulmonary tuberculosis

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