Malignant neurilemomas of peripheral nerves

Vieta, John O.; Pack, George T.

doi:10.1016/0002-9610(51)90368-6

Cited by 99 publications

(15 citation statements)

References 25 publications

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“…8,34) Some transformations occur after radiotherapy 10,11,31,32,36,37) or previous surgery for a benign neurofibroma. The pleiotropic effect of the NF allele on chromosome 17 4,22) is responsible for increasing the risk for both neural crest and nonneural crest malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…21,26) MPNST lesions tend to occur more centrally in patients with NF1, 11,13,31) and peripherally 9,10,12,13) or evenly distributed in patients without NF1. 31) There is a male 8,36) or female 10,31) preponderance or even distribution 8,12) in NF1. Patients with MPNST and NF1 are younger than patients without NF1 (28.7-36 years vs. 39.7-48 years) 10,31) or no age/sex difference is noted, 8,12) and the mean age is 34 years.…”

Section: Discussionmentioning

confidence: 99%

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Malignant Schwannoma of the Sciatic Nerve Originating in a Spinal Plexiform Neurofibroma Associated With Neurofibromatosis Type 1. Case Report.

Topsakal

Akdemir

Tiftikci

et al. 2001

Neurol. Med. Chir.(Tokyo)

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A 26-year-old man with neurofibromatosis type 1 (NF1) presented with a giant malignant schwannoma of the sciatic nerve. The differential diagnosis of malignant peripheral nerve sheath tumor (MPNST) was based on clinical, radiological, and histological evidence. The tumor apparently originated in a spinal plexiform neurofibroma. The lesion was resected totally without neural damage to the sciatic nerve. However, the tumor recurred within 2 months. The patient died of unknown factors probably associated with the spinal involvement. MPNST associated with NF1 has a poor prognosis due to recurrence or metastasis despite complete macroscopic removal.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malignant Schwannoma of the Sciatic Nerve Originating in a Spinal Plexiform Neurofibroma Associated With Neurofibromatosis Type 1. Case Report.

Topsakal

Akdemir

Tiftikci

et al. 2001

Neurol. Med. Chir.(Tokyo)

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“…However, neurosarcoma can occur in neurofi bromatosis and has to be treated by a multimodal thera- 276 Kempf/Becker/Weber/Ruck/Lenarz Neurogenic Tumours in the Head and Neck Area peutic approach with resection, radiation up to 60 Gy and chemotherapy in case of relapse [4], Prognosis of neuro sarcoma is poor [3], which depends on the usually late detection and high rate of metastasis primarily in the lung and bony system as well as on the biological behaviour of the tumour cells [16]. The 5-year survival rate ranges between 23 and 75% and varies due to location of the tumour and the therapy performed [4,[16][17][18][19]. Patients with neurofibromatosis who develop malignant neuromas have a much poorer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Clinical Outcome of Neurogenic Tumours in the Head and Neck Area

Kempf

Becker²,

Weber

et al. 1995

ORL

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A retrospective analysis of diagnostic procedures and clinical outcome of patients with neurogenic tumours of the head and neck region was performed. There were 25 patients – 16 with neurinoma, 5 with neurofibroma and 4 with neurogenic sarcoma – who presented with a mass in the head and neck area. In 13 patients, the neurinoma originated from the facial nerve, 2 of them were located in the middle ear and mastoid and showed facial palsy. Four patients presented with neurofibromatosis type 1. Twenty-three patients were operated on to remove the tumorous masses. Eighteen tumours were assigned intraoperatively to a cranial nerve main trunk, whereas 7 tumours originated from small branches or showed diffuse growth in neurofibromatosis. All benign neurogenic tumours were removed totally without relapse. One of 2 auricular nerve autografts in middle-ear facial nerve neurinoma resulted in a sufficient muscle tonus of the face. Three patients with malignancies died within 12–24 months showing local recurrencies (n = 1) and/or pulmonary metastasis (n = 2). As expected, neurogenic tumours are unusual neoplasms of the head and neck regions. On the other hand, neurogenic malignancies exhibit diagnostic problems as well as uncertain chances for long-term survival. Tumour staging, determined by extension and critical for treatment decisions, is well evaluated by CT scan and MRI. A multimodal therapy regimen with operation and radiation is recommended for neurogenic sarcoma also when developing in neurofibromatosis. However, in main trunk neurinomas, nerve autografting with interposition is the therapy of choice with a good chance of functional recuperation.

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“…I t is of interest in this connection that malignant schwannoma originating within a pre-existent neurilemmoma appears to be extremely rare, if it ever occurs (Saxkn 1948, Vieta & Pack 1951, D'Agostino et al 1963, Das Gupta, et al 1969. Some forms of malignant schwannoma exhibiting so-called schwann-cell differencation with densely packed, often palisading short spindle-cells may show some resemblance to ancient neurilemmoma.…”

Section: Discussionmentioning

confidence: 99%

Ancient Neurilemmoma (Schwannoma)

Dahl

1977

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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Dahl, I. Ancient neurilemmoma (schwannoma) . Acta path. microbiol. scand. Sect. A, 85: 812-818, 1977. A clinical and light microscopic study of 11 patients with ancient neurilemmoma is presented. Ancient neurilemmoma is a cellular form of ordinary neurilemmoma, showing nuclear polymorphism and hyperchromasia. Seven patients were female and 4 were male; their ages ranged between 37 years and 81 years, with a median of 59 years. Seven tumours were 2.5 cm or larger in the widest diameter, and had been slowly enlarging for one year or more. All tumours were mlitary, encapsulated showing nuc!ear polymorphism and hyperchromasia without any mitotic activity. The differential diagnosis is discussed. Follow-up hformation available on all patients confirmed that the clinical course is benign.

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Malignant neurilemomas of peripheral nerves

Cited by 99 publications

References 25 publications

Malignant Schwannoma of the Sciatic Nerve Originating in a Spinal Plexiform Neurofibroma Associated With Neurofibromatosis Type 1. Case Report.

Malignant Schwannoma of the Sciatic Nerve Originating in a Spinal Plexiform Neurofibroma Associated With Neurofibromatosis Type 1. Case Report.

Diagnostic and Clinical Outcome of Neurogenic Tumours in the Head and Neck Area

Ancient Neurilemmoma (Schwannoma)

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