Malignant mixed müllerian tumor (mixed mesodermal tumor of the uterus).A study of twenty-one cases

Sternberg, William H.; Clark, Wallace H.; Smith, Robert C.

doi:10.1002/1097-0142(195407)7:4<704::aid-cncr2820070411>3.0.co;2-d

Cited by 121 publications

(13 citation statements)

References 11 publications

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“…Second, MMMT is a very rare malignancy in the pediatric age group [16,. Third, whereas such pediatric cases may have rhabdomyosarcoma as a component [16,19,21], malignant cartilage has been reported only once [ 161. In contrast, cartilage is found in nearly 50% of rhabdomyosarcomas of the cervix [9], and it has a benign, or metaplastic appearance P I .…”

Section: Rhabdomyosarcoma Of Cervix 75mentioning

confidence: 99%

Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: A clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female

Perrone

Carson

Dehner

1990

Med. Pediatr. Oncol.

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This report concerns a 20-year-old female who had a F.I.G.O. stage I rhabdomyosarcoma (sarcoma botryoides) of the cervix with a predominant embryonal pattern and heterologous cartilage that pursued an aggressive course despite surgery and chemotherapy. The patient had a pelvic recurrence, developed pulmonary metastases 15 months after diagnosis, and died 6 months later. Despite some previously published favorable prognostic assessments about this unique variant of cervical rhabdomyosarcoma, our limited experience would interject a note of caution, especially in the presence of a focal alveolar pattern and invasion of lymphatics in the cervix.

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Section: Rhabdomyosarcoma Of Cervix 75mentioning

confidence: 99%

Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: A clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female

Perrone

Carson

Dehner

1990

Med. Pediatr. Oncol.

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“…Sternberg et al [20] was the first to suggest the conversion, stating that sarcomatous elements may develop from carcinoma. They described a case of metastatic heterologous type carcinosarcoma of the omentum with primary endometrial origin.…”

Section: Discussion and The Review Of Literaturementioning

confidence: 99%

Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

et al. 2011

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Malignant mixed Müllerian tumor is a rare malignancy of the genital tract and extremely uncommon in extragenital sites. This report describes a case of malignant mixed Müllerian tumor arising in the lower peritoneum of a 72-year-old female patient. The patient presented with ascites, lower abdominal mass and pleural effusion. The serum level of CA125 was elevated. At operation a diffuse carcinosis associated with tumor mass measuring 20 × 15 × 10 cm in the vesicouterine and Duglas' pouch were found. The uterus and the adnexa were unremarkable. Histopathology revealed a typical malignant mixed Müllerian tumor, heterologous type. The epithelial component was positive for cytokeratin 7 and vimentin whereas the mesenchymal component was positive for Vimentin, S100 and focally for CK7. The histogenesis of this tumor arising from the peritoneum is still speculative. Based on the previous reports and the immunohistochemical analysis of our case, we believe that this is a monoclonal tumor with carcinoma being the "precursor" element. Nevertheless, further molecular and genetic evidence is needed to support such a conclusion.

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“…The majority of authors agree that the origin of carcinosarcomas and mixed mesodermal tumors in the female genital tract is based on multipotential cells of Miillerian nature (7,13,14,18). In the ovary, these neoplasms possibly originate in celomic (surface epithelial) cells that possess a Miillerian differentiation potential.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcomas and Mixed Mesodermal Tumors of the Ovary: A Clinicopathologic Study of Six Cases

Ortega¹,

Nogales²,

Amérigo³

et al. 1978

Intl J Gynecology & Obste

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A clinicopathologic study of three ovarian carcinosarcomas and three mixed mesodermal tumors of the ovary is presented. None of the patients survived for more than 1 year, irrespective of chemotherapeutic treatment or the extent of surgery. No prognostic differences were noted between the histologic patterns of varying tumor sizes of carcinosarcomas and mixed mesodermal tumors. The association of these two entities with other neoplasms of Müllerian nature suggests a multicentric tumor response of Müllerian tract derivatives. The necessity of adequate sampling, both for correct diagnosis and to exclude the possibility of teratoma (which behaves in a more benign fashion), is emphasized.

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Malignant mixed müllerian tumor (mixed mesodermal tumor of the uterus).A study of twenty-one cases

Cited by 121 publications

References 11 publications

Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: A clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female

Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: A clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female

Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

Carcinosarcomas and Mixed Mesodermal Tumors of the Ovary: A Clinicopathologic Study of Six Cases

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