Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

Kurshumliu, Fisnik; Rung-Hansen, Helle; Skovlund, Vibeke Ravn; Gashi-Luci, Lumturije; Horn, Thomas

doi:10.1186/1477-7819-9-17

Cited by 16 publications

(4 citation statements)

References 18 publications

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“…Apart from the uterine corpus, CSs may develop in various organs, including the uterine cervix [24,25,26], ovary [27,28,29,30], fallopian tube [31], vagina [32,33], Douglas pouch [34] or even the peritoneum [35,36]. Uterine CS arising in a patient with uterus didelphys has been described [37] as well as a rare presentation of scalp metastasis from uterine CS [38].…”

Section: Introductionmentioning

confidence: 99%

Role of p53 Pathway Alterations in Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumors)

et al. 2014

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Carcinosarcomas (CSs; malignant mixed Müllerian tumors) of the uterus are highly malignant neoplasms characterized by an unfavorable outcome. They represent less than 5% of all uterine malignancies, and the median patient survival rate is only 21 months. p53 pathway alterations have been studied in CSs originating from the uterus, supporting the monoclonal nature of most but not all of these neoplasms. This paper gives an overview of the current knowledge of p53 pathway distortions in patients with uterine CSs. The survival of patients with uterine CSs in relation to p53 pathway alterations is also briefly summarized.

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Section: Introductionmentioning

confidence: 99%

Role of p53 Pathway Alterations in Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumors)

et al. 2014

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“…Immunohistochemical panel done showed results as expected for a carcinosarcoma. 11 Closest differentials includes mesothelioma, retroperitoneal soft tissue sarcomas, subserosal leiomyomas, malignancies of kidney, adrenal glands and germ cell tumours. 12 The main mode of treatment is surgery followed by chemo and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Primary retroperitoneal malignant mixed Mullerian tumour: A rare case report

K¹,

Sibby²,

Krishnamurthy³

et al. 2020

JDPO

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Malignant mixed Mullerian tumour commonly known as carcinosarcoma is a rare and aggressive biphasic tumour with epithelial and mesenchymal components. In this reported case, a 68 year old post menopausal, nulliparous female, presented with complaints of difficulty in breathing and abdominal discomfort. Clinical evaluation and radiological findings were consistent with malignancy of left ovarian origin. Patient was taken up for total abdominal hysterectomy with bilateral salpingo-oophorectomy. But intraoperatively, the tumour was found as a single large retroperitoneal mass with no connection to ovaries or other pelvic organs. Histopathological examination of the specimen revealed features of malignant mixed Mullerian tumour. Immunohistochemical markers showed positivity for CK 20, Pan CK and EMA in carcinomatous areas and vimentin in sarcomatous areas. ER and PR were found to be negative. Patient was on regular follow-up and responded well to chemo and radiotherapy. Primaries in retroperitoneum also have poor prognosis similar to carcinosarcomas of female genital tract.

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“…Extragenital MMMTs, although extremely rare, have been reported in the literature. Pelvic peritoneum seems to be the most common site for extragenital MMMTs ( Table 1 ) [ 8 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

Kapur

Levin

2014

Case Reports in Oncological Medicine

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We report a case of a 53-year-old female who presented with chronic constipation and abdominal discomfort for six months. Her past surgical history was significant for a total abdominal hysterectomy with bilateral salpingooophorectomy, performed eight years ago, for uterine fibroids and endometriosis. Workup revealed a mass measuring 5 × 4.5 × 2 cm in the rectosigmoid colon. Patient underwent a low anterior resection and a fungating, centrally ulcerated rectosigmoid mass with a positive mesorectal margin was removed. Histopathology revealed a heterologous mixed mesodermal tumor (chondroid and osteoid elements). The epithelial component was compatible with a grade 2 endometrioid adenocarcinoma. Immunohistochemical stains were supportive, with positive expression for CK7 and ER, negative for CK20, and only very focally and weakly positive for both CDX2 and p63. Chromogranin, synaptophysin, and TTF-1 were negative. Following surgery, she was treated with five cycles of carboplatin (AUC 6) and paclitaxel (175 mg/m2), followed by irradiation. Twenty-six months later, patient continues to be asymptomatic and disease-free. Mixed müllerian mesodermal tumors mimicking colorectal cancer have been reported in the past. Our case highlights the rarity and the challenges encountered in diagnosing and treating these rare tumors.

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Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

Cited by 16 publications

References 18 publications

Role of p53 Pathway Alterations in Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumors)

Role of p53 Pathway Alterations in Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumors)

Primary retroperitoneal malignant mixed Mullerian tumour: A rare case report

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

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