Malignant mesenchymoma

Brady, Mary S.; Perino, Georgio; Tallini, Giovanni; Russo, Paul; Woodruff, James M.

doi:10.1002/(sici)1097-0142(19960201)77:3<467::aid-cncr7>3.0.co;2-h

Cited by 42 publications

(19 citation statements)

References 9 publications

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“…22,25 The term 'malignant mesenchymoma' has been applied to sarcomas that exhibited two or more lines of specialized differentiation. [10][11][12] In spite of strict diagnostic criteria, the existence of malignant mesenchymoma remains controversial and in the latest WHO classification on soft tissue tumors was not regarded as a distinct clinicopathologic entity. 26 Dedifferentiated liposarcoma may exhibit heterologous differentiation in about 5% of cases, mainly with osteo-/chondro-sarcoma or myosarcomatous elements.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the distinction between dedifferentiated liposarcoma showing heterologus components, 8,9 such as osteosarcoma-like morphology, 8 and malignant mesenchymoma characterized by the coexistence of well-differentiated liposarcoma and osteosarcoma still remains obscure. [10][11][12] Therefore, the aim of current series was to better address the aforementioned questions by correlating the morphological variations, extent, and histological grades of dedifferentiation with the clinical evolution, preferential metastatic sites, and postmetastatic survival of seven patients developing distant metastasis from their retroperitoneal dedifferentiated liposarcoma.…”

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confidence: 99%

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Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation

et al. 2005

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The metastatic incidence of retroperitoneal dedifferentiated liposarcoma is comparatively lower than other pleomorphic sarcomas, varying widely from 1 to 18%. Low-grade dedifferentiation resembling low-grade fibrosarcoma has been recently accepted as part of the morphologic spectrum of dedifferentiated liposarcoma and was reported to have similar metastatic and survival rates to its high-grade counterpart. We sought to determine the metastatic incidence of retroperitoneal dedifferentiated liposarcoma, the clinicopathological features related to metastasis, and their postmetastatic behavior. Of all 354 retroperitoneal liposarcoma cases diagnosed at Memorial Sloan-Kettering Cancer Center during 1982-2003, we identified seven patients developing distant metastases, occurring in four females and three males, ranging from 35 to 73 years in age at presentation. They were all de novo dedifferentiated, while none of the well-differentiated liposarcoma or secondary dedifferentiated liposarcoma developed distant metastasis. Primary tumor sizes varied from 7.5 to 25 cm. All seven patients developing metastases contained Z50% dedifferentiated elements in the primary tumor, with a predominant morphology resembling myxofibrosarcoma in five cases. The metastatic sites included the lung in four patients, somatic soft tissue in two, and liver in one. The median metastasis-free survival was 48 months, with only two patients experiencing local recurrences before developing metastasis. Six patients died of disease at median follow-up of 53 months after diagnosis and only 5 months after their first metastases. In conclusion, retroperitoneal dedifferentiated liposarcoma have a low metastatic rate, which is strongly related to de novo dedifferentiated histology that usually constitutes a prominent component of the primary tumor. Irrespective of the grade dedifferentiated liposarcoma with myxofibrosarcoma-like features should be closely monitored. Once metastases occur, they tend to follow a rapidly fatal course. Modern Pathology (2005) 18, 976-984.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation

et al. 2005

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“…Bradythe et al reported in eight femoral and retroperitoneal cases that the survival rates for 2-3 years were 75% and 37%, respectively. [9] However, in a research conducted by Newman, Fletcher et al on six cases, low-grade malignant behavior was identified in these tumors and the follow-up period of four of these cases was <5 years. [10] Adachia et al determined that the presence of the rhabdomyosarcomas component and patients aged 40 years had bad prognosis and that sex, tumor area, tumor size or the MIB-1 classification index findings did not have an impact on the prognosis.…”

Section: Case Reportmentioning

confidence: 99%

Malignant Mesenchymal Tumor of the Prostate: A Case Report

Kandaz¹

2017

TJ Oncol

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SUMMARYNonepithelial tumors of the prostate represent <1% of all prostate tumors. A rare soft tissue sarcoma is common in the lower extremities and can occur anywhere in the body. Malignant mesenchymal tumors of the prostate are rarely observed. The histogenesis of malignant mesenchymal tumors that have totipotential differentiation capacity and arise from primitive mesenchymal cells is still unknown. These are malignant soft tissue sarcomas including ≥2 different mesenchymal elements in addition to the fibrosarcomatous elements. This type of tumors can occur anywhere within the body; the most frequently reported sites are the retroperitoneal cavity and lower extremity. They may occur in the heart, mediastinum, pleura, liver, eyes, bones, larynx, thyroid, testis, uterus, and bladder. The malignant potential is high and the progression of these tumors is rapid. There is mass in the prostate; however, when the prostate-specific antigen levels are normal, differential diagnoses should be considered. Although the main treatment for this disease is surgery, chemotherapy and/or radiotherapy can be applied. We present a rare case of malignant mesenchymal tumor of the prostate.

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“…Terminolojik olarak daha çok heterolog farklanma gösteren leiomyosarkom terimi kullanılmaktadır. En sık görü-len birlikteliği rabdomyosarkom-liposarkom veya rabdomyosarkom-osteo/kondrosarkomdur 3,4 . Tü-mörün en sık yerleşim yeri retroperiton olmakla birlikte, farklı lokalizasyonlarda da geliştiği bildirilmiştir.…”

Section: Introductionunclassified

A very rare Renal Sarcoma: Renal Leiomyosarcoma including heterologous sarcomas - Malign Mesenchymoma

Şenol¹,

Yıldırım²,

Zemherı³

et al. 2015

MMJ

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GİrİŞMalign mezenkimom andiferansiye veya fibrosarkomatöz alanlara ek olarak birbirinden keskin hatlarla ayrılan en az iki ayrı tip ve bariz malign mezenkimal diferansiyasyon gösteren ender bir yumuşak doku tümörüdür 1,2 . Terminolojik olarak daha çok heterolog farklanma gösteren leiomyosarkom terimi kullanılmaktadır. En sık görü-len birlikteliği rabdomyosarkom-liposarkom veya rabdomyosarkom-osteo/kondrosarkomdur 3,4 . Tü-mörün en sık yerleşim yeri retroperiton olmakla birlikte, farklı lokalizasyonlarda da geliştiği bildirilmiştir. Az diferansiye sarkom olan bu tümörlerin prognozları kötü ve nüksleri sıktır. Bu olguda oldukça ender görülen bu tümör, çok daha ender lokalizasyonu nedeni ile öncelikle histopatolojik bulguları ve ayırıcı tanıları yönünden literatür bilgileri ışığında sunulmuştur. olGUElli üç yaşında kadın hasta yan ağrısı ve uylukta kitle nedeniyle polikliniğe başvuran hastanın yapılan radyolojik incelemesinde, sağ böbrek alt pole tutunmuş halde 7 cm çapında, sağ uyluk ön yüzde kas dokusu arasında 3 cm çapında ve karaciğerde, metastaz ile uyumlu en büyüğü 2 cm çapta birkaç adet kitle izlendi. Bunun üzerine parsiyel nefrektomi ve eksizyon yapılarak her iki kitle de patoloji bölümüne gönderil-di. Makroskopik olarak renal kitle, kirli beyaz renkte, santrali kanamalı ve nekrotik alanlar içeren yer yer solit sert kıvamda (Figür 1); uyluktaki kitle solit beyaz renkte, lifsel görünümde idi. Mikroskopik olarak uyluktaki kitlede kollajenize ve fokal miksoid stroma arasında, yer yer pleomorfik görünümde, hiperselü-ler atipili iğsi hücreler izlendi. Tipik mitoz 10 büyük büyütme alanında 3 olarak tespit edildi (Figür 2

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Malignant mesenchymoma

Abstract: Malignant mesenchymoma represents a particularly aggressive form of soft tissue sarcoma. Our experience with this disease highlights the need for more effective treatment strategies for these patients.

Cited by 42 publications

References 9 publications

Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation

Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation

Malignant Mesenchymal Tumor of the Prostate: A Case Report

A very rare Renal Sarcoma: Renal Leiomyosarcoma including heterologous sarcomas - Malign Mesenchymoma

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