Malignant Childhood Proptosis

Bakhshi, Sameer; Singh, Preetpaul; Chawla, Nikhil

doi:10.1097/mph.0b013e31815a0599

Cited by 16 publications

(9 citation statements)

References 15 publications

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“…Retinoblastoma with 11 cases is the most common childhood malignancy causing proptosis. This matches with Bakshi et al (6) study of 104 cases of childhood malignancy wherein Retinoblastoma forms 51% in their study. Secondaries in orbit with 6 cases is second malignancy to cause proptosis among children.…”

Section: Discussionsupporting

confidence: 79%

“…Secondaries in orbit with 6 cases is second malignancy to cause proptosis among children. This again matches with the Bakshi et al, (6) in whose series of 104 cases of malignant causes of childhood proptosis secondaries in orbit is second cause for proptosis. The common primary tumour causing secondaries in our series is Retinoblastoma followed by Neuroblastoma and Lymphoma.…”

Section: Discussionsupporting

confidence: 70%

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Etiopathogenesis of childhood proptosis

Ather¹,

Baig²,

Modini³

et al. 2017

IJOOO

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Aim: To study the etiology, presentation and management of proptosis in children less than 14 years of age Materials and Methods: This is prospective interventional study conducted at the department of Oculoplasty and Orbital diseases of Sarojini Devi eye hospital, Hyderabad. Period of study was from August 2012 to July 2014. 120 eyes of 111 children presenting as proptosis to the department were included in the study. Adult cases of Proptosis were excluded from the study. All cases underwent a detailed proptosis evaluation by an experienced oculoplasty surgeon. CT scan of orbit, axial and coronal view, 2mm cut without contrast was modality of imaging in all cases. CT scan with contrast was done in selected cases. Complete blood picture and surgical profile investigations were done. Cases were posted for excision or incision biopsy under general anaesthesia. Histopathological diagnosis was obtained in required cases. Culture and sensitivity of pus was done in infective cases. Results: 111(14.83%) cases of childhood proptosis were there out of 748 cases of proptosis presented during the study period to the department. The Male to Female ratio was 55:46. 102 cases were of unilateral proptosis and 9 were bilateral. Common etiology for childhood proptosis was 28 congenital, 18 infective, 20 parasitic, 36 neoplasm, 6 secondaries and 3 trauma cases. Of 111 cases 28 had acute proptosis, 25 had Sub acute presentation and 58 cases had chronic presentation. Management of 111 cases was done as follows: 48 cases underwent surgery, 41 were managed medically, 10 cases were referred to Medical Oncologist and 12 cases of congenital crouzons disease and microphthalmos were not intervened. Conclusion: Childhood proptosis forms 14.83% of total proptosis cases presenting at department of Oculoplasty and Orbital diseases. Etiological spectrum is different when compared to adult Proptosis.(1)

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 70%

Etiopathogenesis of childhood proptosis

Ather¹,

Baig²,

Modini³

et al. 2017

IJOOO

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“…Among the inflammatory causes orbital cellulitis was the most common cause (30%) and all cases of inflammatory proptosis were acute in onset. According to the study conducted by Bakshi et al 16 in 2008 among 104 cases of malignant childhood Proptosis secondary tumours (59.6%) were more common than primary tumours (51%) which is similar to my study. In our study, leukemic infiltration was the commonest cause of proptosis due to secondary orbital infiltration.…”

Section: Discussionsupporting

confidence: 78%

A Study on Childhood Proptosis

Anuradha¹,

Keerthana²

2018

jebmh

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“…Etiology should be confirmed after the peripheral smear, MRI, and bone marrow assessment, and with histopathological examinations if needed. [ 4 5 ]…”

Section: Discussionmentioning

confidence: 99%

Bilateral proptosis in a child: A rare presentation of acute lymphoblastic leukemia

Sivaperumal¹,

Latha²,

Narayani³

et al. 2018

J Ophthalmic Vis Res

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Purpose:Acute lymphoblastic leukemia (ALL), a common hematological malignancy observed in children, typically presents with fever, pallor, easy bruising, hepatosplenomegaly and lymphadenopathy. However, when ALL manifests with unusual signs and the blood counts and peripheral smears are normal, it causes a diagnostic dilemma.Case Report:We report a 5-year-old boy who presented with bilateral proptosis as the initial manifestation of ALL. He presented with fever and bilateral knee pain attributed to a fall while playing. There was a history of progressive bilateral proptosis for a 3-month period not associated with any other complaints such as fever, eye pain, redness, or tearing. Thyroid function tests were normal. Blood counts acquired upon proptosis presentation were normal. When he presented to us three months later, blood counts revealed a pancytopenia but the peripheral smear showed no abnormal cells. Magnetic resonance imaging of the brain and orbits was normal. Bone marrow aspirate flow cytometry confirmed the diagnosis of B cell acute lymphoblastic lymphoma.Conclusion:Ophthalmologists should be aware of the unusual ophthalmologic manifestations of acute leukemia, as they may precede overt leukemia and cause diagnostic dilemmas. Knowledge about the rare and isolated extramedullary manifestations of ALL facilitates early diagnosis and thereby improves prognosis.

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Malignant Childhood Proptosis

Cited by 16 publications

References 15 publications

Etiopathogenesis of childhood proptosis

Etiopathogenesis of childhood proptosis

A Study on Childhood Proptosis

Bilateral proptosis in a child: A rare presentation of acute lymphoblastic leukemia

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