Malignant angioendotheliomatosis: An angiotropic lymphoma

Petroff, Nina; Koger, O'Neal W.; Fleming, Matthew G.; Fishleder, Andrew J.; Bergfeld, Wilma F.; Tuthill, Ralph J.; Tubbs, Raymond R.

doi:10.1016/s0190-9622(89)70245-0

Cited by 41 publications

(26 citation statements)

References 16 publications

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“…29,30,36,49,51,53,77,92 Beginning in 1986, authors increasingly included immunohistochemical data of the patients studied by them. 19,20,23,25 The majority of patients had IVL-BCL (86 patients) 31,32,34,35,[38][39][40]42,47,50,53,[55][56][57][58][60][61][62]64,67,68,73,74,77,78,80,82,83,[86][87][88][89]93,95,97 whereas a minority had IVL-TCL (33 patients). 25 In 59 patients no signs and symptoms of the skin were mentioned, and in another 75 patients authors stated specifically that the skin had been uninvolved in the lymphomatous process.…”

Section: Resultsmentioning

confidence: 99%

Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin

Röglin

Böer

2007

Br J Dermatol

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Forty per cent of all patients with IVL have skin lesions, these being red, sometimes painful plaques located typically on the lower extremities, accompanied by oedema. A clinician risks misinterpreting these changes as thrombophlebitis, erythema nodosum or erysipelas. Neither clinical course nor differentiation of the lymphoma can be predicted from the morphology of skin lesions, but involvement of other organs at the time of diagnosis indicates a poor prognosis.

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Section: Resultsmentioning

confidence: 99%

Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin

Röglin

Böer

2007

Br J Dermatol

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“…15 More recent data suggest that modern combination chemotherapy regimens may improve outcome. Combination chemotherapy with or without radiation has resulted in clinical disease remission, 6,7,15,16,[30][31][32][33][34][35][36] some of which are durable. 8,13,16,37 At last follow-up the patient presented in the current study had been recurrence free for Ͼ 4 years, and hopefully has been cured of her disease.…”

Section: Discussionmentioning

confidence: 99%

Superior vena cava syndrome secondary to an angiotropic large cell lymphoma

Savarese

Zavarin

Smyczynski

et al. 2000

Cancer

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“…Malignant angioendotheliomatosis is an intravascular monoclonal lymphoma, usually of phenotypical B cells, first described as a systemic proliferative angioendotheliomatosis by Pleger and Tappeiner in 1959 1 . Since then, more than 15 synonyms have been used for this entity, which is considered to originate from the endothelial vessels 2,3 …”

Section: Discussionmentioning

confidence: 99%

Intravascular large cell lymphoma

Reyes-Castro

Vega‐Memije

2007

Int J Dermatology

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A 19‐year‐old female presented at our hospital with a 1‐year history of a 5‐cm indurated nontender lesion on the left shoulder. Two months later, a similar lesion appeared in the left mammary region, accompanied by necrosis and fever. At admission to our department, she presented disseminated lesions in the left submandibular region, the sternal area and the posterior part of the upper and lower extremities. The lesions were indurated erythematous‐violaceous plaques affecting the adipose tissue, some with ulcerations and necrotic crusting (Fig. 1). The first histopathological report was thrombosis of the capillary vessels and focal vasculitis (Fig. 2). 1 Ulceration and necrotic crusting lesion in the left mammary region 2 Histopathology showing dilation of thrombosed vessels with fibrin deposits (hematoxylin and eosin, magnification ×244) A biopsy from a lesion on the left thigh showed dilated vessels with large atypical intravascular cells with hyperchromatic nuclei and numerous atypical mytoses in the dermis and subcutaneous tissue. Some of these cells were immersed in fibrin thrombi or in the perivascular connective tissue (Fig. 3). An immunohistochemical study was positive for the common leukocytic antigen and for the B‐cell phenotype. The diagnosis was large B‐cell lymphoma. The patient persisted with a high fever, dry cough, pericardial effusion complicated by an abscess and left pleural effusion. She died before systemic workings for lymphoma could be carried out, and before chemotherapy could be attempted. 3 Histopathology showing atypical intravascular lymphocytes (hematoxylin and eosin, magnification ×366)

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Malignant angioendotheliomatosis: An angiotropic lymphoma

Cited by 41 publications

References 16 publications

Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin

Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin

Superior vena cava syndrome secondary to an angiotropic large cell lymphoma

Intravascular large cell lymphoma

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