Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin

Röglin, J.; Böer, Almut

doi:10.1111/j.1365-2133.2007.07954.x

Cited by 99 publications

(101 citation statements)

References 90 publications

(482 reference statements)

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“…Clinically, IVL displays erythema nodosum-like lesions, painful telangiectasias, or livedo racemosa skin lesions. 14 The prognosis of IVL, independent of T-or B-cell origin, is unfavorable, with a 3-year survival rate of 33% for the systemic form of IVL and a relatively better prognosis in its cutaneous form. Expression of CD30 is usually not present in IVL but is a consistent and defining feature of intravascular ALCL (IV-ALCL).…”

Section: Discussionmentioning

confidence: 99%

Benign Atypical Intravascular CD30+ T-Cell Proliferation: A Recently Described Reactive Lymphoproliferative Process and Simulator of Intravascular Lymphoma

Kempf¹,

Keller

John

et al. 2014

American Journal of Clinical Pathology

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Objectives: Intravascular accumulations of atypical large lymphoid cells are a rare finding in skin biopsy specimens and raise the suspicion for intravascular lymphoma. The intravascular accumulation of atypical large CD30+ T cells, however, as a reactive process is very uncommon in the skin, with only four cases documented so far in the literature. This condition, referred to as benign intravascular atypical CD30+ T-cell proliferation, has been associated with chronic inflammation after trauma. Methods: We report on a case of atypical intravascular CD30+ T-cell proliferation in a patient with ulcerated lichen sclerosus on the foreskin, discuss the differential diagnoses, propose diagnostic criteria, and review the literature on this uncommon reactive intralymphatic CD30+ T-cell lymphoproliferation. Results: The atypical intravascular CD30+ T-cell proliferation is characterized by the accumulation of large CD30+ polyclonal T cells within lymphatics in close vicinity to ulceration or an inflammatory skin disease. There is no association with Epstein-Barr virus infection. Conclusions: This benign cutaneous lymphoproliferation needs to be distinguished from intravascular T-cell lymphoma, particularly from the intravascular variant of anaplastic large cell lymphoma. Obstruction of lymphatics due to lichen sclerosus with disrupted immune cell trafficking may result in the accumulation of activated CD30+ lymphocytes.

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Section: Discussionmentioning

confidence: 99%

Benign Atypical Intravascular CD30+ T-Cell Proliferation: A Recently Described Reactive Lymphoproliferative Process and Simulator of Intravascular Lymphoma

Kempf¹,

Keller

John

et al. 2014

American Journal of Clinical Pathology

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“…There is a tendency to spare lymph nodes. A small proportion of patients present with intravascular lymphoma apparently confined to skin at presentation; these patients appear to have a better prognosis then most patients with intravascular large B-cell lymphoma [80,83]. There is a recently described Asian variant of intravascular lymphoma characterized by hepatosplenomegaly, bone marrow involvement, and hemophagocytosis [84][85][86][87]; the involvement of the skin and central nervous system is uncommon in the Asian variant, in contrast to the Western form of the disease.…”

Section: Intravascular Large B-cell Lymphomamentioning

confidence: 99%

The diversity of diffuse large B-cell lymphoma in extranodal sites: overview and update

Ferry

2014

J Hematopathol

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Extranodal lymphomas are a diverse group of low and high grade neoplasms of B-, T-, and NK-cell lineage, each with characteristic sites of origin, morphology, immunophenotype, genetic features, patterns of spread, and prognosis. The diversity is sometimes seen even within a single histologic type of lymphoma. This phenomenon is especially striking in the category of diffuse large B-cell lymphoma (DLBCL). DLBCLs as classified in the WHO Classification are clinically and pathologically heterogeneous . Since the publication of the most recent edition of the WHO Classification of tumours of haematopoietic and lymphoid tissues ), a number of advances in the understanding of these lymphomas have been made. This review provides an overview of extranodal DLBCLs and describes recent updates regarding these lymphomas.

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“…[28] These skin lesions are the result of malignant lymphocytes distributed heterogeneously throughout the papillary and reticular dermal vascular plexuses. [28][29].…”

Section: Introductionmentioning

confidence: 99%

“…[30] One way to select the site of biopsy is reviewing the frequency depending on location, a recent review reported: thigh (41%), leg (35%), trunk (31%), arm (15%), and buttock (7,5%). [28] Based on this review, biopsy specimens from the case of Le et al were taken from the front of the thighs bilaterally, with 3 of the 4 revealing intravascular large B-cell lymphoma. [30] They have done more than one biopsy because of the small size of the biopsy specimen itself.…”

Section: Introductionmentioning

confidence: 99%

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Azul¹,

Vaglio²

2013

Skin Biopsy - Diagnosis and Treatment

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Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin

Cited by 99 publications

References 90 publications

Benign Atypical Intravascular CD30+ T-Cell Proliferation: A Recently Described Reactive Lymphoproliferative Process and Simulator of Intravascular Lymphoma

Benign Atypical Intravascular CD30+ T-Cell Proliferation: A Recently Described Reactive Lymphoproliferative Process and Simulator of Intravascular Lymphoma

The diversity of diffuse large B-cell lymphoma in extranodal sites: overview and update

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