Superior vena cava syndrome secondary to an angiotropic large cell lymphoma

Savarese, Diane; Zavarin, Michael; Smyczynski, M.S.; Rohrer, Michael J.; Hutzler, Michael

doi:10.1002/1097-0142(20001215)89:12<2515::aid-cncr1>3.0.co;2-h

Cited by 23 publications

(16 citation statements)

References 30 publications

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“…A possible exception might be represented by cases with single small cutaneous lesions, which have some probability of cure with a local treatment. Anthracyclines constitute a crucial group of drugs against these malignancies [7,64,69,70], because other regimens without this drug have been associated with disappointing outcome [5,44,71]. Response rate after anthracycline-based chemotherapy is near 60% [8], but its assessment is difficult because measurable disease (i.e., lymphadenopathies and tumor masses) is often lacking; whether the inclusion of B symptoms and laboratory data among measurable disease parameters needs further evaluation.…”

Section: Treatmentmentioning

confidence: 99%

“…Relapses after 5 years of follow-up are rare. In patients treated with anthracycline-based chemotherapy, the 3-year OS is near to 30% (Figure 1); however, long-term survival remains to be defined since follow-up in reported case series is usually short [7,70]. Durable remission after anthracycline-based chemotherapy, the cornerstone of IVL treatment, is most commonly observed in patients with disease limited to the skin, good PS, and small tumor burden [8].…”

Section: Treatmentmentioning

confidence: 99%

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Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes?

Ponzoni

Ferreri

2006

Hematological Oncology

110

135

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Intravascular lymphoma (IVL) is an extremely rare form of non-Hodgkin lymphoma characterized by almost exclusive growth of neoplastic lymphocytes within blood vessel lumen. IVL is morphologically characterized in most instances by large cells with B-cell lineage. IVL is an aggressive and usually disseminated disease that predominantly affects elderly patients, resulting in poor PS, B-symptoms, anemia, and high lactate dehydrogenase serum level. The brain and skin are the most commonly involved sites; nodal disease is rare. Survival after conventional chemotherapy is disappointing, with a relevant impact of diagnostic delay and lethal complications. Notwithstanding these results, IVL limited to the skin (cutaneous variant) is a favorable presentation with distinctive clinical characteristics. Moreover, differences in clinical presentation with Eastern Countries IVL cases, mostly associated with hemophagocytic syndrome, do exist. Intensive combinations containing drugs with higher central nervous system bioavailability are needed in cases with brain involvement; the role of high-dose chemotherapy with autologous stem cell transplantation should be investigated in younger patients with unfavorable features. The present review will discuss the most recent acquisitions related either to diagnosis and immunophenotypic/biologic characteristics as well as clinical/therapeutic issues of IVL.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes?

Ponzoni

Ferreri

2006

Hematological Oncology

110

135

View full text Add to dashboard Cite

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“…Hier steht das kleinzellige Bronchialkarzinom an erster Stelle, das entsprechend der Kreuzung der V. cava superior mit dem rechten Hauptbronchus in diesen Fällen vorwiegend in der rechten Lunge lokalisiert ist [15,24,36]. Aber auch andere Tumoren wie Lymphome (u. a. intrathorakales Plasmozytom, Burkitt-Lymphom), primär mediastinale Tumoren wie Thymome und mediastinale Lymphknotenmetastasen extrathorakaler Primärtumoren wie das metastasierende maligne Melanom, Nieren-, Pharynx-, Blasen-, Uterus-, Ovarial-und Mammakarzinome sind in diesem Zusammenhang zu nennen [5,7,13,15,19,20,31]. Es gibt Untersuchungen, nach denen etwa 8% aller Patienten mit Bronchialkarzinom im Verlauf ihrer malignen Grunderkrankung eine manifeste obere Einflussstauung entwickeln können [34].…”

Section: Therapie Und Verlaufunclassified

Gesichtsödeme bei einem 61-jährigen Patienten

et al. 2002

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“…IVLBCLs involving proliferation within abdominal vessels other than small vessels have been reported. [3][4][5][6][7][8][9] The lymphoma cells have been found in veins such as the mesenteric veins and the saphenous vein. However, IVLBCL with extensive growth within the lumina of large blood vessels, such as the pulmonary trunk, aorta and carotis, has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Intravascular large B‐cell lymphoma involving large blood vessels, three autopsy cases

Sato

Teshima

Nakamura

et al. 2019

Pathology International

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Although intravascular large B‐cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending from the truncus pulmonalis to the pulmonary arteries in Case 1, emboli of lymphoma cells in the aorta and carotis in Case 2, and a mass of lymphoma cells blocking the lumen of the aortic arch in Case 3. This is the first report of IVLBCL involving large blood vessels, and it is essential to note that this type of IVLBCL might cause sudden death because of tumor emboli within large blood vessels.

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Superior vena cava syndrome secondary to an angiotropic large cell lymphoma

Cited by 23 publications

References 30 publications

Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes?

Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes?

Gesichtsödeme bei einem 61-jährigen Patienten

Intravascular large B‐cell lymphoma involving large blood vessels, three autopsy cases

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