Maleic Anhydride in Condensation Polymers

Trivedi, B. C.; Culbertson, B. M.

doi:10.1007/978-1-4757-0940-7_12

Cited by 4 publications

(5 citation statements)

References 170 publications

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“…These modified release methods depend on multiple factors, such as the shape and size of the tablets [ 5 ], the manufacturing process [ 6 ], the granulometric properties [ 7 , 8 , 9 ] and the physicochemical characteristics of the other compounds in the compressed blends, wherein polymer-based excipients are remarkable for their physicochemical properties and the diversity of their multiple applications [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Different kinds of natural, hemisynthetic and synthetic polymers have been used for this purpose, among which the copolymers derived from maleic anhydride have shown great potential as controlled drug release systems [ 10 , 17 , 18 , 19 , 20 , 21 , 22 ]. These kinds of copolymers have attracted great attention due to their biocompatibility characteristics, clearly defined structures and versatility to combine with other precursors leading to a wide variety of polymeric materials with multiple properties and applications [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

et al. 2016

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The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC. The surface properties of the tablets were determined by the sessile drop method, while the surface energy was determined using the semi-empirical Young-Dupre, Neumann and OWRK models. The release profiles were determined simulating in vitro conditions (buffer solutions pH 1.2 and pH 7.4 with ionic strength of 1.5 M at 37 °C (310.15 K)). A kinetic analysis of the dissolution profiles using different models (zero order, first order, Higuchi and Korsmeyer-Peppas) was realized. The results showed a significant effect of the proportion of polymer in both the surface properties of the tablets and the dissolution release, indicating a relationship between the kinetic and thermodynamic properties.

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Section: Introductionmentioning

confidence: 99%

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

et al. 2016

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“…Additional homopolymerisation of styrene was only found to occur, if the molar ratio of styrene to UP double bonds exceeds 9. [69,70] A prevalence of styrene homopolymerisation would lead to both longer poly(styrene) segments between the UP chains and a blend of poly(styrene) and the UP. In the present 10P y series, the mass ratio of styrene to the unsaturated polyester is kept constant.…”

Section: Resultsmentioning

confidence: 99%

Synergistic effects in cross-linked blends of ion-conducting PEO-/PPO-based unsaturated polyesters

Sassmann

Weichold

2021

Ionics

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Ion-conductive unsaturated polyesters (UP) were synthesised from poly(ethylene oxide) (Xn = 9, 13, 22, 90) or poly(propylene oxide) (Xn = 7, 13, 20, 34, 68) and maleic anhydride. Subsequently, the polyesters were doped with LiClO4 and cross-linked with styrene using a redox initiator. For PEO-based polyesters, the minimum resistivity is found at an O/Li+ molar ratio of 50/1. In contrast, more lithium is required to reach the minimum when using PPO (O/Li+ = 10/1). Unlike the PEO-based polyesters, cross-linking of the PPO types gives rise to decreasing resistivities at increasing molecular weight. This correlates well with the transverse proton relaxation time determined by single-sided NMR, which is an indicator of the chain mobility. The cross-linking reaction of these UP with styrene exactly follows the predictions based on the copolymerisation parameters and is, therefore, not dependent on the ratio of styrene to UP double bonds as previously reported. Due to the opposing effects of the molecular weight on the ion conductivity of PEO- and PPO-based UP, 1:1 blends of short-chain PPO and long-chain PEO polyesters were cross-linked with styrene. The resulting networks showed a resistivity of 4 kΩ m (σ = 2.5∙10−4 S∙m−1), which is 5 times lower than the pure PEO and 3 times lower than the pure PPO materials.

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“…The reaction of hydroxyl or carboxyl end groups of rPET chains with the maleic anhydride functionality of the compatibilizer leads to the formation of blocks of chains in the blend, eventually recovering the MFI. 46 This formation of a polymer chain block leads to enhanced miscibility of rLLDPE in the rPET matrix and overall chain mobility is restricted. In order to further prevent the reduction in molecular weight of rPET chains, the chain extender was used in different fractions.…”

Section: Resultsmentioning

confidence: 99%

“…The maleic anhydride ring on the SEBS chain is subjected to opening and works as an anchor for the PET chains. 46 On the other hand, ethylene chains form a homogeneous phase with LLDPE chains. The reaction of hydroxyl or carboxyl end functional groups with the maleic anhydride moiety and the formation of a homogeneous phase slightly enhances the miscibility of the LLDPE chains in the PET chains.…”

Section: Resultsmentioning

confidence: 99%

Novel sustainable materials from waste plastics: compatibilized blend from discarded bale wrap and plastic bottles

2021

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Maleic Anhydride in Condensation Polymers

Cited by 4 publications

References 170 publications

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

Synergistic effects in cross-linked blends of ion-conducting PEO-/PPO-based unsaturated polyesters

Novel sustainable materials from waste plastics: compatibilized blend from discarded bale wrap and plastic bottles

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