“…These modified release methods depend on multiple factors, such as the shape and size of the tablets [ 5 ], the manufacturing process [ 6 ], the granulometric properties [ 7 , 8 , 9 ] and the physicochemical characteristics of the other compounds in the compressed blends, wherein polymer-based excipients are remarkable for their physicochemical properties and the diversity of their multiple applications [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Different kinds of natural, hemisynthetic and synthetic polymers have been used for this purpose, among which the copolymers derived from maleic anhydride have shown great potential as controlled drug release systems [ 10 , 17 , 18 , 19 , 20 , 21 , 22 ]. These kinds of copolymers have attracted great attention due to their biocompatibility characteristics, clearly defined structures and versatility to combine with other precursors leading to a wide variety of polymeric materials with multiple properties and applications [ 23 , 24 ].…”