The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC. The surface properties of the tablets were determined by the sessile drop method, while the surface energy was determined using the semi-empirical Young-Dupre, Neumann and OWRK models. The release profiles were determined simulating in vitro conditions (buffer solutions pH 1.2 and pH 7.4 with ionic strength of 1.5 M at 37 °C (310.15 K)). A kinetic analysis of the dissolution profiles using different models (zero order, first order, Higuchi and Korsmeyer-Peppas) was realized. The results showed a significant effect of the proportion of polymer in both the surface properties of the tablets and the dissolution release, indicating a relationship between the kinetic and thermodynamic properties.
RESUMENDe la parte aérea de 29 especies de plantas recolectadas en la Ecorregión Cafetera Colombiana se obtuvieron por maceración pasiva los extractos de diclorometano y metanol a los cuales se les determinó la actividad antitopoisomerasa empleando cepas mutadas de Saccharomyces cerevisiae por el método de difusión en agar; adicionalmente, se les evaluó la capacidad captadora de radicales libres por los métodos de los radicales 1,1-Difenil-2-picrilhidrazilo (DPPH • ) y ácido 2,2' azinobis-(3-etilbenzotiazolina)-6-sulfónico (ABTS
•+). Así mismo, se determinó el contenido de fenoles totales por el método de Folin-Ciocalteu a todos los extractos que presentaron capacidad antioxidante igual o superior al 25% en el ensayo de DPPH• . Se encontraron 8 extractos de diclorometano y 15 de metanol con actividad antioxidante superior al 25% y alto contenido de fenoles totales.
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