Male breast cancer.I. Histologic typing and grading of 187 Danish cases

Abstract

In a series comprising 265 male patients with breast cancer, histologic typing and grading were carried out in 187 cases using the WHO Classification. Among the 187 patients, a total of 30 cases of special cancer types were found (22 carcinomas and 8 sarcomas). There were no carcinomas of lobular type. The sarcomas in our series had a relatively high frequency and a favorable prognosis. Histologic grading was carried out in 150 carcinomas. The 30 cases of special types and 7 cases with insufficient tumor tissue were excluded. The distribution of the 150 cases was: 29% with Grade I, 54% with Grade II, and 17% with Grade III. The histologic grading was correlated with prognosis, and a significant fall in the 5‐year survival rate was found from Grade I to II and from Grade II to III.

Efficiency of Imaging Modalities in Male Breast Disease: Can Ultrasound Give Additional Information for Assessment of Gynecomastia Evolution?

“…Pure DCIS without an associated infiltrating ductal cancer is less common (2.3-17%) (23,25). The single case of DCIS (14%) in our study was of the papillary subtype, which has been described in more than 75% of DCIS cases in men (27). All of our invasive ductal cancers are moderately or poorly differentiated.…”

Male breast cancer: a review

“…All histologic types of breast cancer seen in women except iobular carcinoma h~ve been described in men (13,33,37,96,97). Infiltrating ductal carcinoma comprises the predominant histologic type in all series, representing greater than 80% of all tumors.…”

“…The value of ablative endocrine therapy for advanced disease was documented over the next quarter century when orchiectomy (22), adrenalectomy (35), and hypophysectomy (49) were all shown to be effective modes of therapy. Several large series offer insight into the clinical features (47), epidemiology (84,97), pathology (32,33), surgical (13,37,95,96) and hormonal (42,46,63) treatment, and prognostic factors influencing survival (60,78). Reports from many countries attest to the universal presence and similarity of the disease (I, 41, 57, 66, 70, 82).…”

“…Infiltrating ductal carcinoma comprises the predominant histologic type in all series, representing greater than 80% of all tumors. Medullary or papillary carcinomas are each seen in 2 to 7°,/o ofall cases (13,33,37,96,97). Males with papillary carcinoma have an excellent prognosis as compared tto other histologic types; almost all patients with this cell type have survived 5 years (13,33,37,96).…”

“…No series have correlated histologic grade, stage and prognosis; however, Visfeldt described a clear relationship between the World Health Organization's classifica~.ion of bJstologic grade and survival in his series (97). Male patients with grade I histology had a 5-and 10-year survival of 555/o and 395/0, respectively.…”