Male breast cancer: a review

Meyskeus, Frank L.; Tormey, Douglass C.; Neifeld, James P.

doi:10.1016/s0305-7372(76)80006-0

Cited by 64 publications

(6 citation statements)

References 67 publications

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“…tions (Meyskens et al -1976). Tamoxifen, an antiestrogenic drug, has been shown to be successful in one case with positive estrogen receptors in breast carcinoma with multiple metastases (Ellison et al -1980).…”

Section: Discussionmentioning

confidence: 99%

“…That observation was confirmed by other reports. Perhaps the risk of Klinefelter patients is influenced by genetic variations in a manner similar to the breast cancer of females at which the presence of two X chromosomes might play a role (Lynch et al -1974;Meyskens et al -1976). The frequency of breast cancer in this syndrome has been explained by chromosomal abnormalities like the presence of two X chromosomes as well as by gynecomastia.…”

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confidence: 99%

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Klinefelter's Syndrome and Breast Cancer

et al. 2009

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IntroductionIn 1965 Jackson (Jackson et al. -1965) reported an unusually high incidence of Klinefelter's syndrome in man with breast cancer. That observation was confirmed by other reports. Including the case reported in the present paper 28 cases of breast cancer associated with Klinefelter's syndrome have been described. The frequency of breast cancer in this syndrome has been explained by chromosomal abnormalities like the presence of two X chromosomes as well as by gynecomastia. The present report describes hormonal alterations, which might be of influence in this disease. Case reportIn 1978 a 44 year old man was admitted to the department of internal medicine for evaluation of bilateral gynecomastia which has been known since 2 years. At the age of 18 the diagnosis of a hypogonadism with azoospermia was established. Since then a decrease of libido was noticed. He showed no eunuchoid habitus. The axillary and pubic hair were normal, but beard was scanty. The phallus was normally developed. The testes were small with a volume of 5 ml. The diagnosis of a Klinfelter's syndrome was suggested. The chromatin positive buccal smear and the XXY karyotype of the chromosomes confirmed the diagnosis. Plasma levels of LH, FSH and prolactin were measured by RIA-KID'S; standards of MRC 68/40 and 69/ 104 respectively were used for calibration. Plasma testosterone was assayed according the method of Nieschlag. The plasma concentrations were: LH = 45.0 mIU/ml, FSH = 18.0 mIU/ml, prolactin = 8.2 ng/ml and testosterone = 3.0 ng/ml. The values were interpreted as a hypergonadotropic hypogonadism with normal prolactin. The patient was subsequently treated with 250 mg testosterone-enanthate at four weeks intervals.In September 1980 the patient again was admitted to the hospital because of painful left breast with retracted mamilla, which showed secretion since 6 months. The mammography suggested an infiltrating carcinoma of the left breast and a gynecomastia Vera of the right. The histological examination revealed an infiltrating undifferentiated carcinoma of the mamms with a productive fibrosis. The determination of steroidhormone receptors in the tumor tissue was carried out by incubation with tritiated estradiol, progesterone (R 5020), dihydrotestosterone and dexamethasone and separation by agargel electrophoresis. 1 13 fmol of estradiol and 45 fmol progesterone were bound per mg cytoplasmatic protein. Both values are above the normal range. Androgenand corticosteroidreceptors could not be detected. andrologia 14 (1982) 318 R. Ries et al.For the evaluation of distant metastases a chest x-ray, an ultrasonogram of the abdomen and the bone scan were performed. No metastases could be detected. The axillary nodes were free. According to the staging classification the tumor had a TI NoMo status. All laboratory data except of the sedimention rate were in the normal range. The carcinoembryonic antigen (CEA) was not elevated. Postoperative radiation therapy was given for one month with a total tumor dose of 46 gy.During a testosterone in...

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Section: Discussionmentioning

confidence: 99%

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Klinefelter's Syndrome and Breast Cancer

et al. 2009

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“…Very few series have been reported from single Institutions (Holleb et al, 1968;Scheike, 19.75;Langlands et al, 1976) and the paucity of cases has led to several series being pooled in reviews of the world literature (Meyskens et al, 1976;Everson & Lippman 1979).…”

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Male breast carcinoma--a review of 301 cases from the Christie Hospital & Holt Radium Institute, Manchester

Ribeiro¹

1985

Br J Cancer

123

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“…Stilboestrol has been used as a first-line therapy, but this will also suppress androgens (Ribeiro, 1976 (Patel et al, 1984;Meyskens et al, 1976). Corticosteroids alone produced a response of 43% after orchidectomy, presumably by suppressing residual adrenal androgen production and hence removing a source of oestrogens (Kantarjian et al, 1983).…”

Section: Resultsmentioning

confidence: 99%

Role of aminoglutethimide in male breast cancer

Harris¹,

Dowsett²,

Stuart-Harris³

et al. 1987

Br J Cancer

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Summary Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidetomised patient responded to amminoglutethimide for 14 months. Oestrone and oestradiol were suppressed by AG in all patients, but not to the levels achieved by orchidectomy. AG produced substantial further oestrogen suppression in the orchidectomised patient and should only be used after orchidectomy.Breast cancer in males is an uncommon disease. It accounts for 1 % of all breast cancers and is frequently sensitive to hormone manipulation (Ribeiro, 1985). Breast cancer in men presents at a more advanced stage and in older age groups compared with women, but when matched for these prognostic variables, survival is similar (Scheike, 1982). Because of these clinical features, systemic endocrine therapy is commonly combined with local treatment, castration being a standard first line endocrine approach.Recently, aminoglutethimide has been shown to be effective in postmenopausal women with breast cancer, the main mechanism of action being inhibition of the peripheral conversion of androgens to oestrogens by aromatase (Harris et al., 1982a;1983a). In men, three quarters of oestradiol produced results from peripheral aromatisation of testosterone (Epstein et al., 1966;Longcope et al., 1969;Wu et al., 1982). Thus aminoglutethimide could potentially be useful either to avoid castration or as a second line endocrine therapy to suppress residual oestrogen production via androgens from the adrenal after castration. Patients and methodsFive men with advanced breast cancer were treated with aminoglutethimide and replacement dose hydrocortisone (20mg twice daily). Four patients received the conventional dose of aminoglutethimide, 250 mg four times daily, and one received 125mg twice daily.Plasma samples were taken before treatment and at 2 weekly intervals for measurement of oestrone, Correspondence: A.L. Harris.

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Male breast cancer: a review

Cited by 64 publications

References 67 publications

Klinefelter's Syndrome and Breast Cancer

Klinefelter's Syndrome and Breast Cancer

Male breast carcinoma--a review of 301 cases from the Christie Hospital & Holt Radium Institute, Manchester

Role of aminoglutethimide in male breast cancer

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