Malassezia furfur skin colonization of infants hospitalized in intensive care units

Powell, Dwight A.; Hayes, John R.; Durrell, Diane E.; Miller, Marcia A.; Marcon, Mario J.

doi:10.1016/s0022-3476(87)80070-7

Cited by 54 publications

(22 citation statements)

References 10 publications

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“…But we cannot attribute whether the source of M. furfur in urine is derived from the perineal skin or not. Perinatal transmission of M alassezia furfur has not been recorded [18]. This was supported also by our observation.…”

Section: Discussionsupporting

confidence: 90%

“…Skin colonization with M. furfur has been found previously in 37% of pre- mature infants [18] and in 25% of all infants in a neonatal unit at 3 weeks of age and in 47% after 2 months of hospitalization [17]. On the contrary, only 5% of healthy infants in a well-baby clinic have been found colonized during their first 3 months [17].…”

Section: Discussionmentioning

confidence: 94%

“…Recently, M.furfur has also shown to cause fatal pulmonary vasculitis [9] and catheter-related sepsis in infants receiving intravenous fat emulsions [10][11][12][13][14][15][16]. The colonization rate is greatest among infants with low gestational age, low birth weight and long hospitalization [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Malassezia furfur colonization of neonates in an intensive care unit

Ahtonen

Lehtonen²,

Kero

et al. 1990

Mycoses

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We studied Malassezia furfur colonization of neonates in the neonatal intensive care unit (NICU) and found that the rate was astonishingly high as compared to the previous studies. In very low birth weight (less than 1,000 g) infants we recorded a colonization rate of 80%, and 4% infants with a birth weight greater than 2,000 g. Under 10 day's hospitalization the rate was 11%, and it was 70% after 20 days spent in the unit. Among the infants with the birth weight less than 1,700 g, antibiotic therapy was recorded as a significant risk factor for colonization. In the infants with a greater birth weight, the colonization rate was independent from the risk factors studied. M. furfur colonization could not be linked with occurrence of any symptoms of signs recorded and colonization by M. furfur was so common in NICU that the predictive value of surveillance cultures is poor.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 94%

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Malassezia furfur colonization of neonates in an intensive care unit

Ahtonen

Lehtonen²,

Kero

et al. 1990

Mycoses

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“…The colonization rates recorded range from 37% (344) to 100% (247) in hospitalized neonates. Factors such as young gestational age (8,29,44,344), low birth weight (8,344), and extended periods of hospitalization (8,29,44,344) may predispose to colonisation in this group. To date, however, no systematic survey of colonization rates has been undertaken in healthy newborns, for whom the picture remains unclear.…”

Section: Distribution Of Malassezia Species On Normal Skinmentioning

confidence: 99%

Immunology of Diseases Associated withMalasseziaSpecies

2002

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SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

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“…Skin colonization with M. sympodialis and M. furfur occurs within the first few weeks to months of life and is generally asymptomatic. Skin colonization with Malassezia species is more common in very low birthweight neonates and seems to correlate with decreasing birthweight and gestational age and with prolonged hospitalization [23]. Several cutaneous conditions have been associated with Malassezia infections in adults, including tinea versicolor (pityriasis versicolor, caused by M. furfur) and seborrheic dermatitis, both of which are uncommon in neonates.…”

Section: Malassezia Speciesmentioning

confidence: 99%