Malaria surveillance in New York City: 1991–1996

McNeeley, David E.; Chu, Alvin; Lowe, Shanti; Layton, Marcelle

doi:10.1016/s1201-9712(98)90114-x

Cited by 21 publications

(9 citation statements)

References 16 publications

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“…Malaria imported into industrialized countries has become increasingly common due to dramatic increases in international travel and migration and the development and spread of drug resistance in malaria parasites (6,14,15). Malaria caused by Plasmodium falciparum can be rapidly fatal.…”

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confidence: 99%

Evaluation of the Makromed Dipstick Assay versus PCR for Diagnosis of Plasmodium falciparum Malaria in Returned Travelers

et al. 2002

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Microscopy has been the traditional reference standard for malaria diagnosis. However, difficulty in maintaining the required technical skills, particularly in areas where malaria is not endemic, has prompted the development of rapid nonmicroscopic diagnostic assays based on the detection of malaria parasite antigen in whole blood. In this study, we evaluated the performance of one such device, the Makromed dipstick test, blindly compared to PCR and microscopy for the diagnosis of Plasmodium falciparum malaria in 200 febrile returned travelers. The Makromed assay detects the presence of P. falciparum-specific histidine-rich protein II with an antigen capture immunochromatographic strip format. Compared to PCR as the reference standard, the dipstick assay had a sensitivity of 97.0% and a specificity of 96.0%. The positive and negative predictive values were 81.2% and 99.5%, respectively. Rapid malaria diagnostic devices may provide a useful diagnostic adjunct in a clinical setting.

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confidence: 99%

Evaluation of the Makromed Dipstick Assay versus PCR for Diagnosis of Plasmodium falciparum Malaria in Returned Travelers

et al. 2002

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“…[1] Plasmodium falciparum and Plasmodium vivax are endemic infections in India and constitutes about 77% of the total malaria cases in Southeast Asia, commonly associated with hematological abnormalities. [2,3] According to World health organization, malaria is the second most fatal communicable disease and is a public health problem in 90 countries of the world. [4] Each year there are more than 250 million cases of malaria, killing 1 to 3 million people.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia and Altered Platelet indices as potential Marker in complicated malaria caused by Plasmodium vivax: cross sectional descriptive study

Bhavani

Venkatraman

A.N³

et al. 2017

APALM

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Background: Malaria is a major health problem with increased morbidity and mortality. Plasmodium falciparum and Plasmodium vivax are endemic infections in India and constitutes about 77% of the total malaria cases in Southeast Asia, commonly associated with hematological abnormalities. Hematological abnormalities that are observed in patients with malaria includes anemia and thrombocytopenia. Thrombocytopenia frequently complicates malarial infections and is usually noted in Plasmodium falciparum. In the present study we have tried to evaluate prognostic implications of altered platelet indices and factors associated with outcome of severe and complicated P. vivax malaria.Methods: This is cross sectional descriptive study of 60 patients with malaria caused by P. vivax who presented to Mahatma Gandhi medical college and research institute between june 2014 to April 2016.The smears positive for malaria exclusively caused by P.vivax infection were included in this study. Malaria was diagnosed by microscopic examination with both leishmain stained thin and giemsa stained thick smears. All blood cell counts were determined using automated equipment (ABX Pentra ES 60; Horiba) which provides MPV, PDW and PCT. Result:Out of 60 patients in the present study 56.7% were males and 43.3% were females, age of the patient ranges from 17-48 years with mean (SD) age of distribution were 32.10 (9.52).Complete blood count evaluation of all patients showed mean hemoglobin level of 9 g/dL. Mean hematocrit level of 26.68% (4.2%) and mean leukocyte count of 5866 (1170) cells/mm3. The mean platelet count was 95,247cells/ mm3. The MPV was 9.6 (0.96) µm, Mean PDW was 13.75% (0.89%) and mean PCT was 0.180% (0.033%) Conclusion: Our study concludes that history of fever associated with chills and rigor are sensitive indicator of malaria but lacks specificity. Platelet indices were altered during severe symptomatic malarial infection such as elevation of MPV and PDW with decreased PCT are the known potential risk factors associated with warning signs of acute malaria caused by plasmodium vivax. Even though these hematological parameters are useful predictors of acute malarial infection, identification of parasites and grading of parasitemia in peripheral smear were always gold standard for early treatment.

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“…[1] It is a vector born disease caused by the bite of female anopheles mosquito inoculating malarial sporozoites in the human blood stream leading to clinical disease manifestations. [2] Four species of plasmodium are recognized to cause disease in mankind.…”

Section: Introductionmentioning

confidence: 99%

Importance of Malarial Exclusion in a Thrombocytopenic Febrile Patient in an Endemic Area

Goel¹,

Vishwanathan²,

Mitra³

et al. 2015

jemds

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AIM OF THE STUDY:To evaluate the role of platelet count for predicting malarial infection and to determine the frequency and severity of thrombocytopenia in malarial parasite positive patients. STUDY DESIGN: The study included 150 patients who presented with fever in Santosh Medical College and Hospital, Ghaziabad. 97 patients with malaria were identified, rest were taken as control. Infection with both plasmodium vivax and plasmodium falciparum species was included. Thrombocytopenia was defined as platelet count less than 150000/cmm. RESULTS: Among 97 patients positive for malarial parasite, 78[80%] were found to have thrombocytopenia Overall 86 patients had plasmodium vivax while 8 patients had plasmodium falciparum infection and 3 had mixed infection. The frequency of thrombocytopenia was 78% [n=67] in vivax and 88% [n=7] in falciparum infection. Our study found the sensitivity of platelet count for diagnosing malaria was 80% and the specificity was 85%. Positive predictive value was 91% and negative predictive value was 83%. CONCLUSION: Platelet count can serve as an important initial screening tool in our setting. A finding of thrombocytopenia should increase the suspicion of malaria and more specific tests should be performed. Thrombocytopenia was a common haematological finding in patients with plasmodium infection, however its presence is not a distinguishing feature between the two types of malaria. Severe thrombocytopenia can occur in plasmodium vivax malaria although it is more common in plasmodium falciparum malaria.

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Malaria surveillance in New York City: 1991–1996

Cited by 21 publications

References 16 publications

Evaluation of the Makromed Dipstick Assay versus PCR for Diagnosis of Plasmodium falciparum Malaria in Returned Travelers

Evaluation of the Makromed Dipstick Assay versus PCR for Diagnosis of Plasmodium falciparum Malaria in Returned Travelers

Thrombocytopenia and Altered Platelet indices as potential Marker in complicated malaria caused by Plasmodium vivax: cross sectional descriptive study

Importance of Malarial Exclusion in a Thrombocytopenic Febrile Patient in an Endemic Area

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