Malacoplakia of the colon

Cipolletta, Livio; Bianco, Maria Antonia; Fumo, F; Orabona, Pasquale; Piccinino, F

doi:10.1016/s0016-5107(95)70351-9

Cited by 24 publications

(21 citation statements)

References 30 publications

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“…The majority of reported cases (∼75$) involve the genitourinary tract [5]. The second most common site is the gastrointestinal tract, and the majority of these cases involve the rectum, sigmoid, and right colon [1, 2]. The remaining cases affect a diverse range of organs, including the lung, brain, adrenal glands, lymph node, tonsils, skin, abdominal wall, liver, pancreas, bone, and the retroperitoneum [6].…”

Section: Discussionmentioning

confidence: 99%

“…The gastrointestinal tract is the most common site of involvement outside of the urinary tract [1, 2]. With regard to the pathogenesis of malakoplakia, the disease is considered to be related to immunosuppression and/or infectious processes [3].…”

Section: Introductionmentioning

confidence: 99%

“…With regard to the pathogenesis of malakoplakia, the disease is considered to be related to immunosuppression and/or infectious processes [3]. The treatment of Malakoplakia varies, ranging from antibiotic therapy to surgical resection [1]. Herein, we describe the case of a 65-year-old male who presented for abdominal pain and unintentional weight loss and was found to have an incidental colonic malakoplakia.…”

Section: Introductionmentioning

confidence: 99%

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Colonic Malakoplakia: A Rare Finding in a Healthy Male

et al. 2018

Case Rep Gastroenterol

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Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside of the urinary tract. Herein, we present a case of a 65-year-old male who presented with abdominal pain and unintentional weight loss. Physical examination findings were unremarkable, but colonoscopy revealed an isolated large, flat, soft, and pale lesion in the transverse colon. Histopathological examination of the lesion showed expansion of the lamina propria due to numerous lymphocytes, plasma cells, neutrophils, and polygonal cells. Von Kossa stain showed small intracytoplasmic basophilic granular inclusions, and these histiocyte cells showed numerous Michaelis-Gutmann bodies, findings considered as diagnostic features of colonic malakoplakia. This is a rare case of isolated malakoplakia of the transverse colon diagnosed on endoscopic specimens. The majority of reported cases have shown an association between systemic diseases and colorectal adenocarcinoma. In addition, most reported cases of colonic involvement have been in the rectum, sigmoid, and right colon.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Colonic Malakoplakia: A Rare Finding in a Healthy Male

et al. 2018

Case Rep Gastroenterol

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“…There is a bimodal age incidence, with one peak for children below 13 years and second peak for middle-aged adults [5]. The mean age at diagnosis was around the fifth decade of age [2].…”

Section: Commentsmentioning

confidence: 99%

“…The diagnosis is exclusively based on histology. The cardinal finding is the presence of numerous histiocytes with pathognomonic intracellular and extracellular Michaelis-Gutmann bodies [5]. …”

Section: Introductionmentioning

confidence: 99%

Digestive Malacoplakia in Children: Case Report

Bouguila

Brahim

Mokni

et al. 2011

ISRN Gastroenterology

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Malacoplakia is a form of chronic granulomatous inflammatory reaction that rarely affects the pediatric age group. The gastrointestinal system is the second most common site for the occurrence of malacoplakia. We report the case of a 9-year-old girl who was hospitalized for abdominal pain, chronic diarrhea, and rectal hemorrhage. The endoscopic examinations and histopathology confirmed the diagnosis of intestinal malacoplakia. We successfully treated her with oral levofloxacin. This disease does not have any specific clinical or biological signs, and the diagnosis is exclusively based on histology.

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