Digestive Malacoplakia in Children: Case Report

Bouguila, Jihéne; Brahim, K.; Mokni, Moncef; Skandrani, K.; Harbi, A.; Essoussi, A. S.; Boughammoura, L.

doi:10.5402/2011/597350

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…Genellikle beşinci ve yedinci dekatlar arasında ve kadınlarda daha sık görüldüğü bildirilmektedir. Bununla birlikte literatürde dokuz yaşında intestinal malakoplaki olgusu rapor edilmiştir (1,4 …”

Section: Discussionunclassified

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Clinical, laboratory, and echocardiographic features of patients with pericardial effusion in Gaziantep region

Ercan¹,

Özer²,

Yavuz³

et al. 2013

Gaziantep Med J

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ÖzetMalakoplaki, kronik granülomatöz inflamatuar bir reaksiyondur. Sıklıkla immün baskılanmış hastalarda oluşur. Makrofajların uygun bir şekilde fagositoz yapamadığı bakteriyel infeksiyona karşı sıra dışı cevabı temsil ettiğine inanılır. En sık üriner ve gastrointestinal sistemi tutar. Spesifik klinik semptomu yoktur. Tanısı histopatolojik inceleme ile konulur. Klinikte üretral kitle ön tanısı ile gönderilen ve histopatolojik inceleme ile malakoplaki tanısı alan olgumuzu literatür eşliğinde sunmayı amaçladık. Anahtar kelimeler: Malakoplaki; ürogenital sistem; üretra. AbstractMalakoplakia is a chronic granulomatous inflammatory reaction. It occurs most frequently in immune compromised patients. It is believed that this entity represents an unusual response to bacterial infection in which macrophages fail to phagocytose them properly. It involves mostly the urinary and gastrointestinal tracts. This disease has not any specific clinic symptom. The diagnosis is based on histopathological examination. We have tried to present the case along with the literature of this kind, which is pre-diagnosed as urethral mass and malakoplakia through histopathological examination in the clinic.

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Section: Discussionunclassified

“…İlk kez 1902 yılında Michaelis ve Gutmann tarafından tanımlanmıştır (1). Daha sonra Von Hansemann "yumuşak plak" anlamına gelen malakoplaki ismini vermiştir (2).…”

Section: Introductionunclassified

Clinical, laboratory, and echocardiographic features of patients with pericardial effusion in Gaziantep region

Ercan¹,

Özer²,

Yavuz³

et al. 2013

Gaziantep Med J

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“…The most accepted theory holds that chronic bacterial infections in patients with chronic weakness or immunosuppression would cause a deficit of cyclic guanosine monophosphate (cGMP) in microtubule and defective macrophage, causing them to phagocyte bacteria, but, in contrast, they would be unable to digest them due to intra-lisosomal failure. This situation would lead to intracytoplasmic deposition of fragments from bacteria, iron, and calcium, which would form the MG bodies (1,3,6,9) . In support of this theory, many studies state that these inclusions represent intake and persistence of bacteria in macrophages (4,5) .…”

Section: Vírus T-linfotrópico Humano Tipo I (Htlv-1) E Diagnóstico Dementioning

confidence: 99%

“…The gastrointestinal tract and retroperitoneal region are the secondary most affected sites (12%-15%) by the disease. Other locations are less affected such as brain, bone, lung, adrenal glands, thyroid, eyeball, among others (3,4,11) . Gupta et al reported, in 1972, the first case of pulmonary malakoplakia, which showed multiple nodules in lower lobe, simulating metastasis (5) .…”

Section: Vírus T-linfotrópico Humano Tipo I (Htlv-1) E Diagnóstico Dementioning

confidence: 99%

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Pulmonary malakoplakia associated with immunodeficiency by HTLV-1 and HIV

Madruga¹,

Nagel²,

Milito³

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Malakoplakia is a rare chronic inflammatory disease often confused with neoplasia. In this paper we report two cases of pulmonary Malakoplakia, both with typical clinical diagnosis of tuberculosis and lung cancer. A patient with human T-lymphotropic virus type I (HTLV-1) and diagnosis of adult T-cell leukemia/lymphoma, and another patient with human immunodeficiency virus (HIV), which was treated for tuberculosis, but, after pulmonary lobectomy, was evidenced Rodococosis equi, progressed to death.

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Gastrointestinal Malakoplakia

Zhang¹,

Byrnes

Lam-Himlin

et al. 2020

American Journal of Surgical Pathology

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Malakoplakia is an inflammatory process related to defective macrophage response to bacterial infection. To further characterize the clinicopathologic manifestations of gastrointestinal malakoplakia, 26 cases were identified from 6 institutions. Hematoxylin and eosin-stained slides and available stains were reviewed, and pertinent clinicopathologic features analyzed. Sixteen patients were women (62%). Mean patient age was 64 (range: 24 to 83). Sites included the colorectum (n=23), appendix (n=1), and stomach (n=2). Clinical indications for tissue procurement included screening (n=14), tumor resection (n=5), diarrhea (n=1), adenoma surveillance (n=1), ulcerative colitis flare (n=1), abdominal pain (n=1), and appendicitis (1). All cases featured histiocytes with abundant, pale, eosinophilic cytoplasm focally containing Michaelis-Gutmann bodies. The process frequently involved the mucosa (n=19), with architectural distortion in 13 cases. Lymphoid aggregates were present in 18 cases, which were prominent or obscuring in 11 (all colon biopsies) and provoked concern for lymphoma in 2. Associated findings included adenocarcinoma (n=5), adenoma (n=2), gastric hyperplastic polyps (n=1), chemical gastritis (n=1), collagenous colitis (n=1), and active chronic colitis (n=2). In cases with available stains, Michaelis-Gutman bodies were highlighted by Periodic Acid-Schiff with diastase, Von Kossa, and iron stains. Although 2 cases were positive for Tropheryma whipplei antibody, no T. whipplei transcripts were detected on real-time polymerase chain reaction. All patients with available follow-up are alive and well with no additional instances of malakoplakia. Malakoplakia of the gastrointestinal tract is a benign, incidental finding. Although histologic features in the stomach and colon resections are similar to those at other sites, exuberant lymphocytic response in colon biopsies and immunoreactivity with T. whippleii antibody may provoke initial confusion and lead to unnecessary time and resource investment.

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Digestive Malacoplakia in Children: Case Report

Cited by 6 publications

References 12 publications

Clinical, laboratory, and echocardiographic features of patients with pericardial effusion in Gaziantep region

Clinical, laboratory, and echocardiographic features of patients with pericardial effusion in Gaziantep region

Pulmonary malakoplakia associated with immunodeficiency by HTLV-1 and HIV

Gastrointestinal Malakoplakia

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