Major sickle cell syndromes in children in Kenitra, Morocco

Hafiani, Khalid; Bazoui, Halima; Madhi, Youssef El; Hafid, My Mustapha; Guamri, Youssef El; Amahmid, Omar; Marhabene, Samira; Kharrim, Khadija El; Belghyti, Driss

doi:10.12980/apjtd.7.2017d7-55

Cited by 3 publications

(3 citation statements)

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“…Morocco, a Mediterranean country, is a potential predilection zone of hemoglobinopathies due to its geographical position. The frequency of the α -mutated genes is believed to be increased due to the country's socioeconomic and cultural system encouraging consanguinity, the selective pressure of malaria in endemic close countries, and its history as a migration crossroad between sub-Saharan Africa and Europe [ 9 , 10 ]. The World Health Organization estimates the rate of hemoglobinopathies carriers in Morocco at 6.5%, with more than 30 000 cases of major forms [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The World Health Organization estimates the rate of hemoglobinopathies carriers in Morocco at 6.5%, with more than 30 000 cases of major forms [ 11 ]. A previous regional study highlighted the region of North Morocco as a geographical hot-spot for hemoglobinopathies due to its high consanguinity rate already estimated and its location in the malaria belt [ 10 , 12 ]. Nevertheless, very scarce data about the occurrence and epidemiology of α -thalassemia is available.…”

Section: Introductionmentioning

confidence: 99%

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Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Laghmich

Ismaili

Barakat

et al. 2019

BioMed Research International

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Unlike the other hemoglobinopathies, few researches have been published concerning α-thalassemia in Morocco. The epidemiological features and the mutation spectrum of this disease are still unknown. This regional newborn screening is the first to study α-thalassemia in the north of Morocco. During the period from January 2015 to December 2016, 1658 newborns umbilical blood samples were investigated. Suspected newborns were screened for α-globin defects using Gap-PCR and Multiplex Ligation-dependent Probe Amplification technique. The prevalence of α-thalassemia, its mutation spectrum, and its allelic frequencies were described for the first time in Morocco. Six different α-globin genetic disorders were detected in 16 neonates. This screening valued the prevalence of α-thalassemia in the studied population at 0.96% and showed the wide mutation spectrum and the heterogeneous geographical distribution of the disease. A high rate of carriers was observed in Laouamra, a rural commune in Larache province. Heterogeneity of α-globin alleles in Morocco explains the high variability of α-thalassemia severity. This diversity reflects the anthropological history of the country. These results would contribute to the prevention of thalassemia in Morocco directing the design of a nationwide screening strategy and awareness campaign.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Laghmich

Ismaili

Barakat

et al. 2019

BioMed Research International

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“…Epidemiologic studies have identified the highest incidence of SCD in the Northwestern region of Morocco. A study of SCD patients from 2011 to 2015 found that SCA was much more prevalent than SCD-SC (81.25% vs. 2.08%) (Hafiani et al 2017). Implementation of NBS and development of a national action plan to improve the quality of SCD management were identified and recommended as ways to improve disease outcomes.…”

Section: Morocco (Kingdom Of Morocco)mentioning

confidence: 99%

Empowering newborn screening programs in African countries through establishment of an international collaborative effort

et al. 2020

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In an effort to explore new knowledge and to develop meaningful collaborations for improving child health, the First Pan African Workshop on Newborn Screening was convened in June 2019 in Rabat, Morocco. Participants included an informal network of newborn screening stakeholders from across Africa and global experts in newborn screening and sickle cell disease. Over 150 attendees, representing 20 countries, were present including 11 African countries. The agenda focused on newborn screening rationale, techniques, system development, implementation barriers, ongoing research, and collaborations both globally and across Africa. We provide an overview of the workshop and a description of the newborn screening activities in the 11 African countries represented at the workshop, with a focus on sickle cell disease.

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Genetic Background of β-Thalassemia in Northeast Algeria with Assessment of the Thalassemia Severity Score and Description of a new β⁰-Thalassemia Frameshift Mutation (HBB: c.374dup; p.Pro126Thrfs*15)

Abdaoui

Benouareth

Djenouni³

et al. 2019

Hemoglobin

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Major sickle cell syndromes in children in Kenitra, Morocco

Cited by 3 publications

References 6 publications

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Empowering newborn screening programs in African countries through establishment of an international collaborative effort

Genetic Background of β-Thalassemia in Northeast Algeria with Assessment of the Thalassemia Severity Score and Description of a new β⁰-Thalassemia Frameshift Mutation (HBB: c.374dup; p.Pro126Thrfs*15)

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Major sickle cell syndromes in children in Kenitra, Morocco

Cited by 3 publications

References 6 publications

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Empowering newborn screening programs in African countries through establishment of an international collaborative effort

Genetic Background of β-Thalassemia in Northeast Algeria with Assessment of the Thalassemia Severity Score and Description of a new β0-Thalassemia Frameshift Mutation (HBB: c.374dup; p.Pro126Thrfs*15)

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Genetic Background of β-Thalassemia in Northeast Algeria with Assessment of the Thalassemia Severity Score and Description of a new β⁰-Thalassemia Frameshift Mutation (HBB: c.374dup; p.Pro126Thrfs*15)