Major metals in human cancer: Calcium, magnesium, sodium and potassium

Ranade, S. S.; Panday, V.K.

doi:10.1016/0048-9697(85)90163-9

Cited by 16 publications

(10 citation statements)

References 4 publications

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“…Single-cell resolution measurements provide an improvement over conventional methods of total Mg determination in tumor versus normal tissues via techniques such as atomic absorption spectroscopy, since homogenization of the tumors would result in mixing of both necrotic and viable portions of the tumor, as well as infiltrating non-neoplastic cells and extracellular fluids, thereby producing inaccuracies in the measurements. Indeed, inconsistent and often contradictory observations of decreased or increased levels of Mg in various types of cancers have been reported based on tissue homogenization methods [34, 35]. Nevertheless, these early studies were valuable in demonstrating that all cancers cannot be grouped under one category and each type should be regarded as a separate entity for the regulation of metal concentrations.…”

Section: Discussionmentioning

confidence: 99%

Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)

et al. 2015

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Glioblastoma multiforme (GBM) is one of the deadliest forms of human brain tumors. The infiltrative pattern of growth of these tumors includes the spread of individual and/or clusters of tumor cells at some distance from the main tumor mass in parts of the brain protected by an intact blood-brain-barrier. Pathophysiological studies of GBM could be greatly enhanced by analytical techniques capable of in situ single-cell resolution measurements of infiltrating tumor cells. Magnesium homeostasis is an area of active investigation in high grade gliomas. In the present study, we have used the F98 rat glioma as a model of human GBM and an elemental/isotopic imaging technique of secondary ion mass spectrometry (SIMS), a CAMECA IMS-3f ion microscope, for studying Mg distributions with single-cell resolution in freeze-dried brain tissue cryosections. Quantitative observations were made on tumor cells in the main tumor mass, contiguous brain tissue, and infiltrating tumor cells in adjacent normal brain. The brain tissue contained a significantly lower total Mg concentration of 4.70 ± 0.93 mmol/Kg wet weight (mean ± SD) in comparison to 11.64 ± 1.96 mmol/Kg wet weight in tumor cells of the main tumor mass and 10.72 ± 1.76 mmol/Kg wet weight in infiltrating tumor cells (p<0.05). The nucleus of individual tumor cells contained elevated levels of bound Mg. These observations demonstrate enhanced Mg-influx and increased binding of Mg in tumor cells and provide strong support for further investigation of GBMs for altered Mg homeostasis and activation of Mg-transporting channels as possible therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)

et al. 2015

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“…A decrease in serum ionized magnesium concentration might at times be secondary to its altered distribution (Table II). The two conditions more likely to be encountered by the hematology/oncology consultant are massive transfusions causing binding of the mineral to citrate and movement of the mineral into the cells of rapidly growing solid tumors 32, 50, 51.…”

Section: Hypomagnesemiamentioning

confidence: 99%

Magnesium homeostasis and hypomagnesemia in children with malignancy

Kaplinsky

Alon

2013

Pediatric Blood & Cancer

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Hypomagnesemia is not uncommon among children with malignancies. It is especially seen in association with certain medications and can be further complicated by the presence of diarrhea and malnutrition. Severe hypomagnesemia may cause disturbances in the neuromuscular and cardiovascular systems. All patients with hypomagnesemia should be supplemented with the mineral, and urgent treatment is indicated when serum magnesium decreases below 1.0 mg/dl, a level under which symptoms may develop. This review addresses the essentials of magnesium physiology, and pathophysiology of hypomagnesemia, its etiologies, clinical manifestations and ways to treat it, with an emphasis on the child with hematologic/oncologic disorders.

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“…In Table 2, the concentrations of some elements in bonemarrow fluid obtained by NAA 7 and AAS [8][9][10] are also shown as literature values. Since NAA generally allows multielement analysis, the analytical values for 7 elements in bone-marrow fluid are provided in the literature for NAA.…”

Section: Determination Of Major-to-ultratrace Elements In Bone-marrowmentioning

confidence: 99%

“…The analytical results for the bone-marrow fluid sample are summarized in Table 2, where the literature values of the elements in bone-marrow fluid obtained by NAA (neutron activation analysis) 7 and AAS (atomic absorption spectrometry) [8][9][10] are also shown for a comparison. It can be seen from Table 2 that 20 elements in bone-marrow fluid could be determined in the present experiment, which were in the concentration range from 1610 µg g -1 for Na to 0.00043 µg g -1 for W. In Table 2, the observed values obtained in the present experiment are expressed as the mean of 3 replicated measurements, together with their standard deviation (SD) and relative standard deviation (RSD).…”

Section: Determination Of Major-to-ultratrace Elements In Bone-marrowmentioning

confidence: 99%

“…6 In our literature survey, however, only a few reports about the elemental distributions in bonemarrow fluid have so far been published in terms of a limited number of elements. [7][8][9][10] Thus, in the present work, the multielement determination of the elements in bone marrow fluid was performed to elucidate the distributions of diverse elements at the major-to-ultratrace concentration levels.…”

Section: Introductionmentioning

confidence: 99%

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Major-to-Ultratrace Elements in Bone-Marrow Fluid as Determined by ICP-AES and ICP-MS

2003

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The major-to-ultratrace elements in human bone-marrow fluid were determined by ICP-AES (inductively coupled plasma atomic emission spectrometry), and ICP-MS (inductively coupled plasma mass spectrometry). The bone-marrow fluid sample was centrifuged prior to acid digestion to exclude the bone piece from bone marrow, and then digested with nitric acid. As a result, 20 elements could be determined over the concentration range from 1610 µg g -1 for Na to 0.00043 µg g -1 for W. It was found that Fe, Zn and Sb were enriched by ca. 264-, 7-and 15-fold, respectively, in bone-marrow fluid, compared to those in human blood serum. Alkali metals (K, Rb, Cs), except for Na, were also significantly enriched in bone-marrow fluid. Furthermore, the concentrations of various elements, such as Fe, P, Al, Zn, Cu, Se, Zr, Sn, Ag and W, were significantly higher than those in open seawater.

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Major metals in human cancer: Calcium, magnesium, sodium and potassium

Cited by 16 publications

References 4 publications

Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)

Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)

Magnesium homeostasis and hypomagnesemia in children with malignancy

Major-to-Ultratrace Elements in Bone-Marrow Fluid as Determined by ICP-AES and ICP-MS

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