Major metabolites after degradation of xenobiotics and enzymes involved in these pathways

Bhatt, Pankaj; Pathak, Vinay Mohan; Joshi, Samiksha; Bisht, Tara Sigh; Singh, Kuldeep; Chandra, Dinesh

doi:10.1016/b978-0-12-818307-6.00012-3

Cited by 34 publications

(10 citation statements)

References 10 publications

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“…Because of enantioselectivity, a few essterases exhibit specific or moderate kinetic abilities, which differ from pyrethroid degrading enzymes. Enzyme expression and metabolites production during pyrethroid degradation is differential and can be sequentially up-regulated or down regulated (Bhatt et al, 2019b). Metagenomic based library was useful for the identification and mining of pyrethroid degrading genes, such as pytY and pytZ ( O. anthropi strain YZ1), estP ( Klebsiella sp.…”

Section: Gene Cloning and Enzymatic Characterization Of Pyrethroid Camentioning

confidence: 99%

“…Every living cell that can survive in different environmental conditions must has metabolic pathways, which help to fetch required food (nutrition) from the surroundings (soil, water). Oxygenases (monooxygenases and dioxygensases) play important role in biodegradation of pesticides by common pathways (Fuchs et al, 2011; Birolli et al, 2016b; Bhatt et al, 2019b). Pyrethroid degrading cells (bacteria, fungi and some animal cells) produce metabolites and make them accessory for downstream pathways (Figure 2).…”

Section: Metabolic Pathways Of Pyrethroid Biodegradationmentioning

confidence: 99%

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Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

et al. 2019

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Pyrethroids are broad-spectrum insecticides and presence of chiral carbon differentiates among various forms of pyrethroids. Microbial approaches have emerged as a popular solution to counter pyrethroid toxicity to marine life and mammals. Bacterial and fungal strains can effectively degrade pyrethroids into non-toxic compounds. Different strains of bacteria and fungi such as Bacillus spp., Raoultella ornithinolytica, Psudomonas flourescens , Brevibacterium sp., Acinetobactor sp., Aspergillus sp., Candida sp., Trichoderma sp., and Candia spp., are used for the biodegradation of pyrethroids. Hydrolysis of ester bond by enzyme esterase/carboxyl esterase is the initial step in pyrethroid biodegradation. Esterase is found in bacteria, fungi, insect and mammalian liver microsome cells that indicates its hydrolysis ability in living cells. Biodegradation pattern and detected metabolites reveal microbial consumption of pyrethroids as carbon and nitrogen source. In this review, we aim to explore pyrethroid degrading strains, enzymes and metabolites produced by microbial strains. This review paper covers in-depth knowledge of pyrethroids and recommends possible solutions to minimize their environmental toxicity.

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Section: Gene Cloning and Enzymatic Characterization Of Pyrethroid Camentioning

confidence: 99%

Section: Metabolic Pathways Of Pyrethroid Biodegradationmentioning

confidence: 99%

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

et al. 2019

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“…Central metabolism of aromatic hydrocarbons involves ortho- and meta-cleavage of catechol and alkylcatechols [ 9 , 10 ]. Further oxidation results in the formation of oxoadipate and aldehydes, with the former being metabolised via succinyl-CoA and the latter via acetyl-CoA and propanoyl-CoA [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Metagenome Analysis of a Hydrocarbon-Degrading Bacterial Consortium Reveals the Specific Roles of BTEX Biodegraders

Eze

2021

Genes

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Environmental contamination by petroleum hydrocarbons is of concern due to the carcinogenicity and neurotoxicity of these compounds. Successful bioremediation of organic contaminants requires bacterial populations with degradative capacity for these contaminants. Through successive enrichment of microorganisms from a petroleum-contaminated soil using diesel fuel as the sole carbon and energy source, we successfully isolated a bacterial consortium that can degrade diesel fuel hydrocarbons. Metagenome analysis revealed the specific roles of different microbial populations involved in the degradation of benzene, toluene, ethylbenzene and xylene (BTEX), and the metabolic pathways involved in these reactions. One hundred and five putative coding DNA sequences were identified as responsible for both the activation of BTEX and central metabolism (ring-cleavage) of catechol and alkylcatechols during BTEX degradation. The majority of the Coding DNA sequences (CDSs) were affiliated to Acidocella, which was also the dominant bacterial genus in the consortium. The inoculation of diesel fuel contaminated soils with the consortium resulted in approximately 70% hydrocarbon biodegradation, indicating the potential of the consortium for environmental remediation of petroleum hydrocarbons.

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“…More specifically, microorganisms are able to metabolize structurally distinct compounds at mild conditions and route them toward a single product, a feat incredibly difficult using purely chemical technologies. Host selection can be achieved by selecting either native isolates from waste streams (Bhatt et al., 2019 ) or through metabolically engineered hosts using enzymes from these isolates. Regardless of the tact, microbial fermentation reroutes carbon toward high-value products while detoxifying waste, as depicted in Fig.…”

Section: Introductionmentioning

confidence: 99%

Microbial valorization of underutilized and nonconventional waste streams

Lad

Coleman

Alper

2021

Journal of Industrial Microbiology and Biotechnology

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The growing burden of waste disposal coupled with natural resource scarcity has renewed interest in the remediation, valorization and/or repurposing of waste. Traditional approaches such as composting, anaerobic digestion, use in fertilizers or animal feed, or incineration for energy production extract very little value out of these waste streams. In contrast, waste valorization into fuels and other biochemicals via microbial fermentation is an area of growing interest. In this review, we discuss microbial valorization of nonconventional, aqueous waste streams such as food processing effluents, wastewater streams, and other industrial wastes. We categorize these waste streams as carbohydrate-rich food wastes, lipid-rich wastes, and other industrial wastes. Recent advances in microbial valorization of these nonconventional waste streams are highlighted, along with a discussion of the specific challenges and opportunities associated with impurities, nitrogen content, toxicity, and low productivity.

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Major metabolites after degradation of xenobiotics and enzymes involved in these pathways

Cited by 34 publications

References 10 publications

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

Metagenome Analysis of a Hydrocarbon-Degrading Bacterial Consortium Reveals the Specific Roles of BTEX Biodegraders

Microbial valorization of underutilized and nonconventional waste streams

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