Magnitude and associated factors of neonatal sepsis among neonates admitted to neonatal intensive care unit of Northern oromia hospitals, Ethiopia: A multicenter cross-sectional study

Bekele, Kumera; Bekele, Firomsa; Edosa, Dejene; Mekonnen, Mathewos; Benayew, Mengistu

doi:10.1016/j.amsu.2022.103782

Cited by 6 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The maternal factors were history of urinary tract infection in the mother (13 studies) ( 31 , 45 , 53 , 55 , 56 , 61 , 62 , 65 , 66 , 68–71 ), parity (10 studies) ( 31 , 45 , 48 , 53 , 56 , 61 , 62 , 65 , 67 , 68 ), prolonged labor (5 studies) ( 31 , 53 , 62 , 69 , 73 ), intrapartum fever (13 studies) ( 31 , 45 , 48 , 52 , 55 , 56 , 61 , 64 , 66 , 68 , 70 , 72 , 73 ), multiple vaginal examinations (7 studies) ( 45 , 53 , 61 , 64 , 66–68 ), performance of ANC (13 studies) (45, 48, 50, 55, 61, 64, 65, 67–71), prolonged rupture of membranes (18 studies) ( 31 , 33 , 45 , 46 , 52 , 53 , 56 , 61 , 62 , 65–73 ), and mode of delivery (14 studies) ( 31 , 32 , 35 , 44 , 46 , 48 , 52 , 61 , 62 , 64 , 66–68 …”

Section: Resultsmentioning

confidence: 99%

Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis

Traoré,

Sidibé,

Diallo

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

ObjectivesThis study aimed to determine the prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa.MethodsThis systematic review and meta-analysis used the PRISMA guideline on sepsis data in sub-Saharan Africa. The bibliographic search was carried out on the following databases: Medline/PubMed, Cochrane Library, African Index Medicus, and Google Scholar. Additionally, the reference lists of the included studies were screened for potentially relevant studies. The last search was conducted on 15 October 2022. The Joanna Briggs Institute quality assessment checklist was applied for critical appraisal. Estimates of the prevalence of maternal and neonatal sepsis were pooled using a random-effects meta-analysis model. Heterogeneity between studies was estimated using the Q statistic and the I2 statistic. The funnel plot and Egger’s regression test were used to assess the publication bias.ResultsA total of 39 studies were included in our review: 32 studies on neonatal sepsis and 7 studies on maternal sepsis. The overall pooled prevalence of maternal and neonatal sepsis in Sub-Saharan Africa was 19.21% (95% CI, 11.46–26.97) and 36.02% (CI: 26.68–45.36), respectively. The meta-analyses revealed that Apgar score < 7 (OR: 2.4, 95% CI: 1.6–3.5), meconium in the amniotic fluid (OR: 2.9, 95% CI: 1.8–4.5), prolonged rupture of membranes >12 h (OR: 2.8, 95% CI: 1.9–4.1), male sex (OR: 1.2, 95% CI: 1.1–1.4), intrapartum fever (OR: 2.4, 95% CI: 1.5–3.7), and history of urinary tract infection in the mother (OR: 2.7, 95% CI: 1.4–5.2) are factors associated with neonatal sepsis. Rural residence (OR: 2.3, 95% CI: 1.01–10.9), parity (OR: 0.5, 95% CI: 0.3–0.7), prolonged labor (OR: 3.4, 95% CI: 1.6–6.9), and multiple digital vaginal examinations (OR: 4.4, 95% CI: 1.3–14.3) were significantly associated with maternal sepsis.ConclusionThe prevalence of maternal and neonatal sepsis was high in sub-Saharan Africa. Multiple factors associated with neonatal and maternal sepsis were identified. These factors could help in the prevention and development of strategies to combat maternal and neonatal sepsis. Given the high risk of bias and high heterogeneity, further high-quality research is needed in the sub-Saharan African context, including a meta-analysis of individual data.Systematic review registration: PROSPERO (ID: CRD42022382050).

show abstract

Section: Resultsmentioning

confidence: 99%

Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis

Traoré,

Sidibé,

Diallo

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…This result was pooled from two studies [ 31 , 38 ]. The pooled odds ratio indicated that a neonate born to a mother with a urinary tract infection is 3.80 (OR = 3.80, 95% CI: 2.58–5.58) more likely to develop neonatal sepsis than mothers without urinary tract infection ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Determinants of neonatal sepsis among neonates admitted to neonatal intensive care units in ethiopian hospitals: A systematic review and meta-analysis

Seyoum,

Sahiledengle,

Kene

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Using the single population proportion formula, the sample size was calculated using the following assumptions: 95% confidence level (for the standard normal deviation with the corresponding value = 1.96) and a 5% margin of error, and taking the prevalence of neonatal sepsis at 52.3% from a previous study performed in northern Oromia ( 25 ). Since the total number of our study population (neonates admitted to the NICU within the past year) was less than 10,000, the final sample size estimated by using the correction formula was 205.…”

Section: Methodsmentioning

confidence: 99%

Neonatal sepsis and its associated factors among neonates admitted to the neonatal intensive care unit in Wachemo University Comprehensive Specialized Hospital, Southern Ethiopia, 2022

Mezgebu,

Ossabo,

Zekiwos

et al. 2023

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundNeonatal sepsis is a major public health problem worldwide. It is one of the leading causes of neonatal mortality and morbidity worldwide. The neonatal mortality rate is higher in developing countries, where the extent and causes of neonatal sepsis are not yet known. Neonatal sepsis is a leading cause of neonatal mortality in Ethiopia. As a result, this study aimed to assess the proportion and identify maternal and neonatal risk factors for neonatal sepsis among neonates admitted to the neonatal intensive care unit.MethodsAn institutional-based cross-sectional study was conducted from May 2022 to July 2022 at the Wachemo University Comprehensive Specialized Teaching Hospital, Neonatal Intensive Care Unit, southern Ethiopia. A total of 205 neonates with indexed mothers participated in the study. Using a consecutive sampling technique, a structured, pretested questionnaire was used to collect data from the study subjects. Data were entered into EpiData Manager version 3.1 for Windows and then exported to SPSS version 22 for further data cleaning and analysis. Descriptive analyses were performed by using frequency, percentage, and summary statistics to describe the key variables. A multivariate regression model was used to identify factors associated with neonatal sepsis. Finally, statistical significance was declared at a p-value of less than 0.05, and an adjusted odds ratio (AOR) with a 95% confidence level was used to declare the variable’s association with the outcome variable.ResultThe overall prevalence rate of neonatal sepsis was 39.5% (95% CI: 33.7–45.9). Multivariable analysis was performed by taking a variable that is statistically significant in bivariate logistic regression as a candidate variable. Multivariable model analysis showed that unmarried status AOR = 18.37 (95% CI: 1.56–216.14), maternal fever during delivery AOR = 4.74 (95% CI: 1.63–13.8), and premature rupture of membrane AOR = 7.53 (95% CI: 2.19–25.6) were variables that increased the odds of developing neonatal sepsis.ConclusionThe study’s findings indicate that neonatal sepsis is highly prevalent. Unmarried maternal status, maternal fever during delivery, and premature rupture of the membrane were predictors of neonatal sepsis. Therefore, providing training for health workers and close monitoring and evaluation during obstetric and neonatal care are crucial to halt the occurrence of neonatal sepsis.

show abstract

Magnitude and associated factors of neonatal sepsis among neonates admitted to neonatal intensive care unit of Northern oromia hospitals, Ethiopia: A multicenter cross-sectional study

Cited by 6 publications

References 19 publications

Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis

Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis

Determinants of neonatal sepsis among neonates admitted to neonatal intensive care units in ethiopian hospitals: A systematic review and meta-analysis

Neonatal sepsis and its associated factors among neonates admitted to the neonatal intensive care unit in Wachemo University Comprehensive Specialized Hospital, Southern Ethiopia, 2022

Contact Info

Product

Resources

About