Determinants of neonatal sepsis among neonates admitted to neonatal intensive care units in ethiopian hospitals: A systematic review and meta-analysis

Seyoum, Kenbon; Sahiledengle, Biniyam; Kene, Chala; Geta, Girma; Gomora, Degefa; Ejigu, Neway; Mesfin, Telila; Kumar Chattu, Vijay

doi:10.1016/j.heliyon.2023.e20336

Cited by 3 publications

(6 citation statements)

References 36 publications

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“…Neonatal-related factors were found to be significantly associated with neonatal sepsis in three SRMA studies 11 , 12 , 56 . One SRMA 11 study showed that neonatal sepsis and low birth weight were significantly correlated.…”

Section: Resultsmentioning

confidence: 99%

“…All of the systematic reviews and meta-analysis studies have been published in the last three years. Of the included SRMA studies, two 11 , 18 reported both the prevalence and determinants of neonatal sepsis, two 19 , 20 reported only factors, and one 15 reported only prevalence. According to the included five SRMA studies, the reported estimate of the prevalence of neonatal sepsis ranged from 40.25% (95% CI:34.00%, 46.50%; I 2 =99.2%) 18 to 49.98% (CI: 36.06, 63.90) 11 .…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, six primary studies 47 – 52 were specific to only Seyoum et al . 20 , two primary studies 53 , 54 were only taken into account by Bayih et al . 18 , and one primary study 55 was included by Desta et al .…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, neonates having low APGAR scores at first and fifth minutes were 3.74 and 2.72 times more likely to develop neonatal sepsis than neonates with normal APGAR scores [(OR:3.74, 95 CI:1.29–10.81)] and [(OR:2.72, 95 CI:2.02–3.67)], respectively in one of the SRMA studies 56 .…”

Section: Resultsmentioning

confidence: 99%

“…Of the reported factors, maternal-related factors were significantly associated with neonatal sepsis in two SRMA studies 18 , 56 . One SRMA study 18 revealed that when compared to neonates born to women without prenatal urinary tract infection, those with antenatal urinary tract infection had a 3.55-fold increased risk (OR=3.55, 95% CI: 2.04–5.06) of developing neonatal sepsis.…”

Section: Resultsmentioning

confidence: 99%

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Neonatal sepsis and its predictors in Ethiopia: umbrella reviews of a systematic review and meta-analysis, 2023

Eyeberu,

Musa,

Debella

2023

Annals of Medicine &Amp; Surgery

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Background: Although neonatal sepsis is acknowledged as the primary cause of newborn death in Ethiopia, data on its impact at the national level are limited. Strong supporting data are required to demonstrate how this affects neonatal health. This umbrella study was conducted to determine the overall prevalence of newborn sepsis and its relationship with maternal and neonatal factors. Methods: This umbrella review included five articles from various databases. The AMSTAR-2 method was used to assess the quality of included systematic review and meta-analysis studies. STATA Version 18 software was used for statistical analysis. A random effects model was used to estimate the overall effects. Results: In this umbrella review, 9032 neonates with an outcome of interest were included. The overall pooled prevalence of neonatal sepsis was 45% (95% CI: 39%–51%; I2=99.34). The overall pooled effect size showed that prematurity was significantly associated with neonatal sepsis [OR=3.11 (95% CI: 2.22-3.99)]. Furthermore, maternal factors are strongly associated with neonatal sepsis. Conclusions: Nearly half of Ethiopian neonates are affected by neonatal sepsis. It is critical to reduce premature birth, low birth weight, and preterm membrane rupture to reduce the incidence of neonatal sepsis. Furthermore, it is preferable to design and strengthen policies and programs aimed at improving maternal nutritional status and treating maternal infections, which all contribute to lowering the burden of neonatal sepsis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Neonatal sepsis and its predictors in Ethiopia: umbrella reviews of a systematic review and meta-analysis, 2023

Eyeberu,

Musa,

Debella

2023

Annals of Medicine &Amp; Surgery

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Magnitude of neonatal sepsis and its associated factors among neonates admitted to the neonatal intensive care unit in Hawassa Comprehensive Specialized Hospital, Sidama Regional State, Ethiopia, 2020

Baheru,

Shiferaw,

Toru

et al. 2024

BMC Pregnancy Childbirth

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Background Neonatal sepsis is one of the most common causes of disease and death among neonates globally. And it made a great contribution to neonatal admission to intensive care units. To mitigate the ongoing neonatal crisis and accomplish the goal of sustainable development through a decrease in neonatal mortality, information from various regions is needed. Despite the considerable burden of neonatal sepsis in our setting, no prior studies were conducted in the study area. So, this study aimed to assess the magnitude and associated factors of neonatal sepsis among neonates admitted to the neonatal intensive care unit at Hawassa University Comprehensive Specialized Hospital, Sidama Regional State, Ethiopia. Methods A hospital-based cross-sectional study was carried out among 287 neonates from March 1, 2020, to April 25, 2020. An interviewer-administered structured questionnaire was used to collect the data. The data were cleaned, coded, and entered into Epi Data 3.1 software and exported to Statistical Package for Social Science (SPSS) software version 23.0 for analysis. Binary logistic regression analyses were performed to identify variables having a significant association with neonatal sepsis. A p-value of ≤ 0.05 was considered statistically significant during multivariable logistic regression. Results The study found that the magnitude of neonatal sepsis was 56%. The mean age of neonates was 3.2(SD±2.2) days. Around two-fifths (39%) of neonates were in the gestational age of <37 completed weeks. A quarter of mothers(25.8%) were delivered through cesarean section. During labor, 251 (87.5%) mothers had ≤4 digital vaginal examinations. Moreover, the finding revealed that mothers who delivered by cesarean section [AOR = 2.13, 95% CI (1.090-4.163)]. neonates who had been resuscitated at birth [AOR = 4.5, 95% CI (2.083-9.707)], and neonates who had NG tube inserted [AOR = 4.29, 95% CI (2.302-8.004)] were found to be significantly associated with neonatal sepsis. Conclusions The current study shows that neonatal sepsis was prevalent among more than half of the neonates admitted to the NICU. Therefore, designing strategies to enhance the aseptic techniques of professionals in the provision of care and actively and collaboratively working with cluster health facilities is highly recommended.

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Comparison of short-term maternal and neonatal outcomes between elective and emergent Cesarean section: A single center experience

Lukić,

Lazić-Mitrović,

Rovčanin

et al. 2024

Medicinska istraživanja

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Introduction/Aim: Increased rates of Cesarean section (CS) and subsequent short-term and long-term maternal complications (MC) and neonatal complications (NC) have been reported. The aim of this study was to compare short-term MC and NC between elective and emergent CS. Material and Methods: Data from medical records of pregnant women who had undergone CS at Gynecology and Obstetrics Clinic "Narodni front" were retrospectively collected. The inclusion criteria were as follows: low-risk, term monofetal pregnancies with obstetrical CS-indications and other non-life-threatening maternal conditions (ophthalmological, orthopedic, psychiatric, lower genital-tract infections). Short-term MC were the following: surgical complications, inflammatory syndrome, the need for blood transfusion, and hospital stay ≥5 days. NC were as follows: respiratory morbidity, asphyxia, sepsis, injuries/lacerations, admission to neonatal intensive-care-unit, hospital stay >4 days. Results: We included 1056 singleton pregnancies. Mean age was 32.63±5.38 years, mainly primipara 566 (53.6%). Of all CS, 774 (73%) were performed emergently. Cephalopelvic disproportion/fetal macrosomia and other CS indications carried a significantly high risk for emergent CS (OR=3.943, 95%CI 2.036-6.591; OR=7.560, 95%CI 3.994-8.327, respectively). Regardless of the urgency of CS there were no significant differences in the frequency of MC. Neonatal sepsis was significantly higher after emergent CS (p=0.027), with a two-times greater risk for its development (OR=2.070, 95% CI 1.072-3.997). There were no fatal maternal/neonatal outcomes and no need for additional care. Conclusion: There were no notable disparities in MC and NC among the individuals who had undergone emergent and elective CS. Neonates born by means of emergent CS had a higher risk of developing neonatal sepsis. Indications for CS had a greater impact on short-term maternal and fetal outcomes than the type of CS.

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Determinants of neonatal sepsis among neonates admitted to neonatal intensive care units in ethiopian hospitals: A systematic review and meta-analysis

Cited by 3 publications

References 36 publications

Neonatal sepsis and its predictors in Ethiopia: umbrella reviews of a systematic review and meta-analysis, 2023

Neonatal sepsis and its predictors in Ethiopia: umbrella reviews of a systematic review and meta-analysis, 2023

Magnitude of neonatal sepsis and its associated factors among neonates admitted to the neonatal intensive care unit in Hawassa Comprehensive Specialized Hospital, Sidama Regional State, Ethiopia, 2020

Comparison of short-term maternal and neonatal outcomes between elective and emergent Cesarean section: A single center experience

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