Magnetoimpedance Thin Film Sensor for Detecting of Stray Fields of Magnetic Particles in Blood Vessel

Abstract

Multilayered [FeNi (100 nm)/Cu (3 nm)]5/Cu (500 nm)/[Cu (3 nm)/[FeNi (100 nm)]5 structures were used as sensitive elements of the magnetoimpedance (MI) sensor prototype for model experiments of the detection of magnetic particles in blood vessel. Non-ferromagnetic cylindrical polymer rod with a small magnetic inclusion was used as a sample mimicking thrombus in a blood vessel. The polymer rod was made of epoxy resin with an inclusion of an epoxy composite containing 30% weight fraction of commercial magnetite microparticles. The position of the magnetic inclusion mimicking thrombus in the blood vessel was detected by the measurements of the stray magnetic fields of microparticles using MI element. Changes of the MI ratio in the presence of composite can be characterized by the shift and the decrease of the maximum value of the MI. We were able to detect the position of the magnetic composite sample mimicking thrombus in blood vessels. Comsol modeling was successfully used for the analysis of the obtained experimental results and the understanding of the origin the MI sensitivity in proposed configuration. We describe possible applications of studied configuration of MI detection for biomedical applications in the field of thrombus state evaluation and therapy.

A Model for the Magnetoimpedance Effect in Non-Symmetric Nanostructured Multilayered Films with Ferrogel Coverings

“…Recently we have reported w promising way for the detection of magnetic particles in blood vessels in the course of model experiments with multilayered [FeNi (100 nm)/Cu (3 nm)] 5 /Cu (500 nm)/[Cu (3 nm)/[FeNi (100 nm)] 5 magnetoimpedance sensitive elements [ 41 ].…”

Magnetic Nanowires for Nanobarcoding and Beyond

“…Recently, MNWs became the center of the research in nanobarcoding because of the revealed potential for making the next generation of nanobarcodes and/or biolabels [ 23 , 24 , 25 , 26 ], driven by the fact that the MNWs can be remotely and selectively detected [ 27 , 28 , 29 ]. Moreover, the MNWs are dominantly fabricated using electrodeposition techniques that are cheap, fast, and scalable for mass production [ 30 , 31 , 32 , 33 ].…”

Directional Field-Dependence of Magnetoimpedance Effect on Integrated YIG/Pt-Stripline System

“…Hence, from the technological point of view, the MI effect arises as a sharp tool to detect small magnetic field changes. In addition, materials exhibiting MI appear as sensitive field sensor elements that can be integrated into a wide variety of electronic devices [ 11 , 12 , 13 , 14 , 15 , 16 ].…”

“…In recent years, the interest in the MI effect has increased, which at first glance may be based on the increasing demand for biosensors [ 12 , 17 , 18 , 19 , 20 , 21 ]. Within this field, different groups have recently reported interesting results.…”

“…In this case, the studied ribbon is quite thick, favoring the obtainment of high MI variations at the low frequency regime, an essential feature to the integration of the MI-sensor elements into devices. Following a different line, Yu and coworkers [ 12 ] have investigated the MI effect in thin films as a sensor to detect magnetic particles in blood vessels. Remarkably, the analyzed multilayer films present significant MI sensitivity despite the smaller thickness of the samples, reaching up to 41%/Oe for low field variations at the moderate frequency regime.…”