Magnetoelectric 3D scaffolds for enhanced bone cell proliferation

Mushtaq, Fajer; Torlakcik, Harun; Vallmajó-Martín, Queralt; Siringil, Erdem; Zhang, Jianhua; Röhrig, Christian; Shen, Yang; Yu, Yingchuan; Chen, Xiang‐Zhong; Müller, Ralph; Nelson, Bradley J.; Pané, Salvador

doi:10.1016/j.apmt.2019.06.004

Cited by 59 publications

(39 citation statements)

References 63 publications

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“…On the other side, the 3D porous structure of the inverse opal materials is very facilitated to the distribution of oxygen/nutrients/cells (Zhang and Xia, 2012). Thus, the inverse opal materials have been widely investigated in biomedical applications such as cellular co-culture (Kim et al, 2014;Im et al, 2017;Mushtaq et al, 2019), cell migration (Stachowiak and Irvine, 2008;Zhang et al, 2013;Mushtaq et al, 2019), and fabrication of multicellular spheroids (Zhang and Xia, 2012;Zhang et al, 2017). However, their application in guiding the oriented growth of neurons has not been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals

Xia

Shang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Isotropic inverse opal structures have been extensively studied for the ability to manipulate cell behaviors such as attachment, migration, and spheroid formation. However, their use in regulate the behaviors of neural stem cells has not been fully explored, besides, the isotropic inverse opal structures usually lack the ability to induce the oriented cell growth which is fundamental in neural regeneration based on neural stem cell therapy. In this paper, the anisotropic inverse opal substrates were obtained by mechanically stretching the poly (vinylidene fluoride) (PVDF) inverse opal films. The anisotropic inverse opal substrates possessed good biocompatibility, optical properties and anisotropy, provided well guidance for the formation of neural spheroids, the alignment of neural stem cells, the differentiation of neural stem cells, the oriented growth of derived neurons and the dendritic complexity of the newborn neurons. Thus, we conclude that the anisotropic inverse opal substrates possess great potential in neural regeneration applications.

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Section: Introductionmentioning

confidence: 99%

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals

Xia

Shang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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“…Sr/BG-G/nHAp Freeze-drying Oryan et al [7] SrHAp/CS Lei et al [39] Sr/MgP bioceramics Solid state sintering Sarkar et al [9] Zn-MBGNs Microemulsion-asisted sol-gel Neščáková et al [10] dECM/BCP Freeze-thaw /SDS solution immersion Kim et al [13] CS/G/A-dECM MOIP-PLGA Thermal-induced phase separation Shen et al [95] HA-MA/PLGA Controlled directional cooling/ lyophilization Dai et al [97] RAFSs Electrospinning Shin et al [98] SiO2 NF-CS Sol-gel electrospinning/ lyophilization Wang et al [111,112] SiO2-CaO NF/CS PLA/PLA-HA 3D printing/casting/salt leaching Grottkau et al [260] BG-CFS Solvothermal method/3D printing Dang et al [116] Ca-P/polydopamine nanolayer surface 3D printing Ma et al [134] MoS2 nanosheets and AKT bioceramic 3D printing/hydrothermal method Wang et al [117] nHA/GO/CS Modified Hummer's method/ lyophilization Ma et al [30] BPs-PLGA Solvent exfoliation/ solvent evaporation Tong et al [118] Hierarchical intrafibrillarly mineralized collagen(HIMC) Two steps self-assembly Liu et al [29] CFO@BFO/PLLA Microfluidic device/hydrothermal / sol-gel Mushtaq et al [150] Fe3O4/MBG/PCL Co-precipitation/3D printing Zhang et al [157] PVDP/CoFe2O4 Solvent casting Fernandes et al [262] nHA/Fe3O4 NPs-CS/COL Crystallization/freeze-drying Zhao et al [263] Ti/W/TiO2 Two-photon lithography(TPL) direct laser writing Maggi et al [27] Porine demineralized bone matrix scaffolds Decalcification Hu et al [175] [193] rGO/BG/osteoblast-specific aptamer Evaporation-induced self-assembly/ heat-treating/reciprocating oscillation Wang et al [203] Van-pBNPs/pep@pSiCaP-Ti Adapted with permission [31]. Fig.9 Schematic illustration of the construction of nHA/GO particles, nHA/GO/CS scaffolds, and their bio-applications.…”

Section: Scaffold Materials Fabrication Technique Referencementioning

confidence: 99%

“…By mimicking such micro-/nanostructural characteristics of bone tissues, cell actions such as migration, adhesion, proliferation, as well as differentiation could be regulated, further promoting bone regeneration [17,18]. Meanwhile, in addition to biochemical signals, ambient physical stimuli such as electrical and magnetic factors, can also influence cells and are able to further prompt bone regeneration [19][20][21]. Based on previous reports, bone tissue, which possesses piezoelectric properties, can generate charges or potentials in response to mechanical stimuli and have the capacity of enhancing bone growth [22].…”

Section: Introductionmentioning

confidence: 99%

“…The application of magnetoelectric scaffolds and restoration of the physiological electric microenvironment in bone tissue regeneration can further regulate cell fate and optimize biomaterial design [19,23]. Evolving strategies that combine external environmental physical cues with the intrinsic features of materials and modulated scaffold systems can thus be utilized to synergistically drive bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy

Jiang

Wang

2020

Bioengineering & Transla Med

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In clinical terms, bone grafting currently involves the application of autogenous, allogeneic, or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as polymers, bioceramics, and other composites. Many of these are associated with limitations. The ideal scaffold for bone tissue engineering should provide mechanical support while promoting osteogenesis, osteoconduction, and even osteoinduction. There are various structural complications and engineering difficulties to be considered. Here, we describe the biomimetic possibilities of the modification of natural or synthetic materials through physical and chemical design to facilitate bone tissue repair. This review summarizes recent progresses in the strategies for constructing biomimetic scaffolds, including ion‐functionalized scaffolds, decellularized extracellular matrix scaffolds, and micro‐ and nano‐scale biomimetic scaffold structures, as well as reactive scaffolds induced by physical factors, and other acellular scaffolds. The fabrication techniques for these scaffolds, along with current strategies in clinical bone repair, are described. The developments in each category are discussed in terms of the connection between the scaffold materials and tissue repair, as well as the interactions with endogenous cells. As the advances in bone tissue engineering move toward application in the clinical setting, the demonstration of the therapeutic efficacy of these novel scaffold designs is critical.

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“…From the different types of magnetoactive materials that can be used for magnetoactive proximity sensors, magnetoelectric (ME) [15,16] composites and related devices represent a growing field over the last decade, due to the magnetic to electric energy conversion capability [17], the magnetic control of polarization and also the possibility of obtaining self-powered devices [18]. These ME composites have emerged as a solution to overcome the limitations of single-phase ME materials, namely, low-temperature coupling and low-ME effect [19,20], allowing innovative functionalities to develop ultra-fast, multifunctional and miniaturized devices [17,21,22].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Proximity Sensor Based on Magnetoelectric Composites and Printed Coils

et al. 2020

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Magnetic sensors are mandatory in a broad range of applications nowadays, being the increasing interest on such sensors mainly driven by the growing demand of materials required by Industry 4.0 and the Internet of Things concept. Optimized power consumption, reliability, flexibility, versatility, lightweight and low-temperature fabrication are some of the technological requirements in which the scientific community is focusing efforts. Aiming to positively respond to those challenges, this work reports magnetic proximity sensors based on magnetoelectric (ME) polyvinylidene fluoride (PVDF)/Metglas composites and an excitation-printed coil. The proposed magnetic proximity sensor shows a maximum resonant ME coefficient (α) of 50.2 Vcm −1 Oe −1 , an AC linear response (R 2 = 0.997) and a maximum voltage output of 362 mV, which suggests suitability for proximity-sensing applications in the areas of aerospace, automotive, positioning, machine safety, recreation and advertising panels, among others.

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Magnetoelectric 3D scaffolds for enhanced bone cell proliferation

Cited by 59 publications

References 63 publications

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals

A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy

Magnetic Proximity Sensor Based on Magnetoelectric Composites and Printed Coils

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