Smart and functional materials processed by printing technologies reveal an increasing interest due to small cost assembly, easy integration into devices and the possibility to obtain multifunctional materials over flexible and large areas. After introducing smart materials, printing technologies and inks, this review discusses the materials that are already being printed, mainly piezoelectric, piezoresistive, magnetostrictive, shape memory polymers (SMP), pH sensitive and chromic system materials. Since polymer-based smart materials are particularly attractive for device implementation, this review will focus on printed polymer-based smart materials. Finally, critical challenges and future research directions will be addressed.
This work reports on the influence of the substrate polarization of electroactive β-poly(vinylidene fluoride) (β-PVDF) on human adipose stem cells (hASCs) differentiation under static and dynamic conditions. hASCs were cultured on different β-PVDF surfaces (non-poled and "poled -") adsorbed with fibronectin and osteogenic differentiation was determined using a quantitative alkaline phosphatase assay. "Poled -" β-PVDF samples promote higher osteogenic differentiation, which is even higher under dynamic conditions. It is thus demonstrated that electroactive membranes can provide the necessary electromechanical stimuli for the differentiation of specific cells and therefore will support the design of suitable tissue engineering strategies, such as bone tissue engineering.
This work reports on the influence of the polarization of electroactive poly(vinylidene fluoride), PVDF, on the biological response of cells cultivated under static and dynamic conditions. Non-poled and ''poled +'' b-PVDF with and without a titanium layer were thus prepared. A thin titanium layer was deposited on PVDF films in order to obtain a more homogeneous surface charge. The MC3T3-E1 osteoblast cell culture exhibited different responses in the presence of PVDF films. The positively charged b-PVDF films promote higher osteoblast adhesion and proliferation, which is higher under dynamic conditions on poled samples, showing that the surface charge under mechanical stimulation improves the osteoblast growth. Therefore, electroactive membranes and scaffolds can provide the necessary electrical stimuli for the growth and proliferation of specific cells.
A novel approach for tissue engineering applications based on the use of magnetoelectric materials is presented. This work proves that magnetoelectric Terfenol-D/poly(vinylidene fluoride-co-trifluoroethylene) composites are able to provide mechanical and electrical stimuli to MC3T3-E1 pre-osteoblast cells and that those stimuli can be remotely triggered by an applied magnetic field. Cell proliferation is enhanced up to ≈ 25% when cells are cultured under mechanical (up to 110 ppm) and electrical stimulation (up to 0.115 mV), showing that magnetoelectric cell stimulation is a novel and suitable approach for tissue engineering allowing magnetic, mechanical and electrical stimuli.
Bone tissue repair strategies are gaining increasing
relevance
due to the growing incidence of bone disorders worldwide. Biochemical
stimulation is the most commonly used strategy for cell regeneration,
while the application of physical cues, including magnetic, mechanical,
or electrical fields, is a promising, however, scarcely investigated
field. This work reports on novel magnetoactive three-dimensional
(3D) porous scaffolds suitable for effective proliferation of osteoblasts
in a biomimetic microenvironment. This physically active microenvironment
is developed through the bone-mimicking structure of the scaffold
combined with the physical stimuli provided by a magnetic custom-made
bioreactor on a magnetoresponsive scaffold. Scaffolds are obtained
through the development of nanocomposites comprised of a piezoelectric
polymer, poly(vinylidene fluoride) (PVDF), and magnetostrictive particles
of CoFe2O4, using a solvent casting method guided
by the overlapping of nylon template structures with three different
fiber diameter sizes (60, 80, and 120 μm), thus generating 3D
scaffolds with different pore sizes. The magnetoactive composites
show a structure very similar to trabecular bone with pore sizes that
range from 5 to 20 μm, owing to the inherent process of crystallization
of PVDF with the nanoparticles (NPs), interconnected with bigger pores,
formed after removing the nylon templates. It is found that the materials
crystallize in the electroactive β-phase of PVDF and promote
the proliferation of preosteoblasts through the application of magnetic
stimuli. This phenomenon is attributed to both local magnetomechanical
and magnetoelectric response of the scaffolds, which induce a proper
cellular mechano- and electro-transduction process.
Strain sensors with different architectures, such as single sensors, sensor arrays and a sensor matrix have been developed by inkjet printing technology. Sensors with gauge factors up to 2.48, dimensions of 1.5 mm × 1.8 mm and interdigitated structures with a distance of 30 μm between the finger lines have been achieved based on PeDOT (poly(3,4-ethylenedioxythiophene) and conductive ink. Strain gauges based on silver ink have also been achieved with a gauge factor of 0.35. Performance tests including 1000 mechanical cycles have been successfully carried out for the development of smart prosthesis applications.
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