Magneto-chemotherapy for cervical cancer treatment with camptothecin loaded Fe3O4 functionalized β-cyclodextrin nanovehicle

Rajan, Mariappan; Krishnan, Poorani; Pradeepkumar, Periyakaruppan; Mayandi, J.; Jeyaraj, Murugaraj; Ling, Mok Pooi; Arulselvan, Palanisamy; Higuchi, Akon; Munusamy, Murugan A.; Arumugam, Ramitha; Benelli, Giovanni; Murugan, Kadarkarai; Kumar, Suresh

doi:10.1039/c7ra06615e

Cited by 34 publications

(20 citation statements)

References 54 publications

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“…The IC 50 values of the nano-conjugates were much lower than that of the free CPT solution, which can be attributed to the increased solubility of CPT by nano-conjugation. The results were consistent with previous research that demonstrated CPT-conjugated NPs had a higher cell inhibition effect than free CPT against cervical cancer 30 and colon cancer. 31…”

Section: In Vitro Cytotoxicitysupporting

confidence: 93%

The impact of camptothecin-encapsulated poly(lactic-co-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro

Bao

Zhang

Zhao

2019

IJN

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BackgroundPoly(lactic-co-glycolic acid) (PLGA) has emerged as a promising anticancer drug delivery scaffold. Camptothecin (CPT) has been fabricated into a variety of nanosized formulations to improve drug action. We report an experimental study on the effect of CPT-encapsulated PLGA (PLGA-CPT) nanoparticles (NPs) on drug-metabolizing cytochrome P450 enzyme, CYP3A4.Materials and methodsPLGA-CPT NPs were prepared by a single emulsion–solvent evaporation method.ResultsTransmission electron micrography showed that the NPs had a round and regular shape with a mean diameter of 94.6±5.7 nm. An in vitro drug release study showed that CPT was continuously released for 48 h. PLGA-CPT NPs showed greater cytotoxic effects on the HepG2 cell line compared with an equal dose of free CPT. Correlation with 4-h uptake data suggested that this was due to a higher cellular uptake amount of CPT from PLGA-CPT NPs than from free CPT. PLGA-CPT NPs tended to inhibit CYP3A4 activity isolated from HepG2 cells. However, PLGA-CPT NPs had no effect on the CYP3A4 mRNA levels. Furthermore, the interaction between PLGA-CPT NPs and CYP3A4 was investigated by ultraviolet–visible absorption spectroscopy and fluorescence spectroscopy.ConclusionTaken together, the results demonstrate that CYP3A4 may be inhibited by PLGA-CPT NPs and interference with biotransformation should be considered when using NPs as drug delivery vesicles.

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Section: In Vitro Cytotoxicitysupporting

confidence: 93%

The impact of camptothecin-encapsulated poly(lactic-co-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro

Bao

Zhang

Zhao

2019

IJN

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“…Increase in the duration of the drug exposure decreased the viability of the cells, which implies the release of the drug into the medium as the time increases and had impact on the cells. Rajan et al [ 47 ] have also found camptothecin loaded magnetite nanoparticle to induce apoptosis against HeLa cells and they found magnetite to be a better drug delivering agent.…”

Section: Resultsmentioning

confidence: 99%

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery

et al. 2018

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In this study, super paramagnetic iron oxide nanoparticles (SPIONs) were produced by chemical co-precipitation method, then it was constructed to be a core shell nanoparticle by functionalizing with SDS, loading with curcumin and coating with a biopolymer i.e. chitosan. Each step was analyzed microscopically and spectroscopically. The produced coreshell particles were between 40 and 45nm and these coreshell particles were utilized for drug delivery studies against cervical cancer cell line—HeLa cells. The coreshell SPIONs were found to be releasing curcumin in between 6 and 12 h, which was evidenced by increased apoptotic cells and increased caspase 3 expression in HeLa cells.

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“…Nanotechnology is exploited in the field of biomedical application for imaging, targeted drug delivery, biosensors, treatment, etc. [5,6]. Apart from these, it has also found applications in environmental for cleaning up environmental pollutants [7], dye removal [8][9][10], waste water treatment [11], heavy metal removal [12], etc.…”

Section: Introductionmentioning

confidence: 99%

Azadirachta indica influenced biosynthesis of super-paramagnetic iron-oxide nanoparticles and their applications in tannery water treatment and X-ray imaging

et al. 2018

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Super-paramagnetic iron-oxide nanoparticles (SPIONs) have been exploited from a very long time and are researched profoundly due to their unique properties. In this study, SPIONs were synthesized using environmentally accepted green synthesis process where Azadirachta indica leaf extract was used as one of the reducing agents along with basic metal precursors used in chemical processes. The synthesized SPIONs were characterised using microscopic analysis (SEM, TEM, and AFM), spectroscopic analysis (FT-IR, UV-Vis, XRD, Raman, and zeta potential), and magnetometry (SQUID). The SPIONs were then tested for its application in the removal of heavy metals from tannery waste water and also X-ray imaging.

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Magneto-chemotherapy for cervical cancer treatment with camptothecin loaded Fe₃O₄ functionalized β-cyclodextrin nanovehicle

Abstract: We portray a novel way to synthesis of iron oxide magnetic nanoparticle incorporated β-cyclodextrin (β-CD) nanocarrier stabilized by ethylenediamine tetra acetic acid (EDTA) obtaining remarkable biocompatibility and biodegradability.

Cited by 34 publications

References 54 publications

The impact of camptothecin-encapsulated poly(lactic-<em>co</em>-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro

The impact of camptothecin-encapsulated poly(lactic-<em>co</em>-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro

Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery

Azadirachta indica influenced biosynthesis of super-paramagnetic iron-oxide nanoparticles and their applications in tannery water treatment and X-ray imaging

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