Magnetite nanocluster@poly(dopamine)-PEG@ indocyanine green nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo

Wu, Ming; Wang, Qingtang; Zhang, Da; Liao, Naishun; Wu, Lingjie; Huang, Aimin; Liu, Xiaolong

doi:10.1016/j.colsurfb.2016.02.022

Cited by 53 publications

(26 citation statements)

References 36 publications

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“…Photothermal therapy employs photoabsorbers to generate heat from light absorption, resulting in thermal ablation of tumor cells 60 . Nowadays, photothermal therapy has emerged as an alternative treatment for cancer with minimal invasiveness compared to other cancer interventions 61 . ICG is recognised as an effective photosensitiser by NIR laser-excitation for photothermal therapy 45 .…”

Section: Icg Nps For Imaging-guided Therapy Of Cancermentioning

confidence: 99%

“…The application of MRI-guided tumor photothermal ablation is impeded by insufficient photothermal ablation and low accumulation of most nanomaterials in tumor tissues 61 . Wu et al developed a magnetite nanocluster@poly(dopamine)-PEG@ICG nanobead for tumor MR imaging and photothermal therapy using a magnetite nanocluster core coated with poly(dopamine), that was then conjugated with PEG and ICG was absorbed on the surface 61 . The tumor-homing ability of these developed nanomaterials was significantly enhanced, as shown by MRI, and photothermal ablation of liver tumors was more efficient at a relatively low dose.…”

Section: Icg Nps For Imaging-guided Therapy Of Cancermentioning

confidence: 99%

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Indocyanine green-incorporating nanoparticles for cancer theranostics

et al. 2018

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Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic applications. Various types of ICG-incorporated NPs have been developed and strategically functionalised to embrace multiple imaging and therapeutic techniques for cancer diagnosis and treatment. This review systematically summaries the biodistribution of various types of ICG-incorporated NPs for the first time, and discusses the principles, opportunities, limitations, and application of ICG-incorporated NPs for cancer theranostics. We believe that ICG-incorporated NPs would be a promising multifunctional theranostic platform in oncology and facilitate significant advancements in this research-active area.

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Section: Icg Nps For Imaging-guided Therapy Of Cancermentioning

confidence: 99%

Section: Icg Nps For Imaging-guided Therapy Of Cancermentioning

confidence: 99%

Indocyanine green-incorporating nanoparticles for cancer theranostics

et al. 2018

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“…Finally, the negatively charged near-infrared fluorescent dye ICG was chosen to be attached on the surface of UCNPs@PDA via strong electrostatic attraction, hydrophobic interaction and π-π stacking, resulting in the formation of UCNPs@PDA-ICG (labeled as UPI). 35,36 In order to furture varify the successful synthesis of UPI, the absorption spectra and FTIR spectra of UPI were carried out. Firstly, the supernatant of the UPI solution after centrifugation was isolated and measured.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional UCNPs@PDA-ICG nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy

et al. 2016

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Integrated theranostic nanosystems that combine therapeutic methods with suitable medical imaging modality are highly needed in the improvement of cancer theranostic approaches. Herein, polydopamine (PDA)-shelled NaYF4: Yb,Er@NaYF4: Yb nanoparticles (UCNPs) capable of loading indocyanine green (ICG) molecules via electrostatic adsorption, hydrophobic interaction and π-π stacking were successfully designed and synthesized (UCNPs@PDA-ICG, labeled as UPI) for upconversion imaging and combined photothermal/photodynamic therapy (PTT/PDT) with enhanced antitumor efficacy. We have found that ICG in this novel anticancer nanoplatform can be triggered impressively by 808 nm to produce both photothermal effect and cytotoxic reactive oxygen species (ROS), thus achieving a good PTT/PDT synergistic effect. Notably, compared with free ICG molecules, UPI nanocomposites show much higher photostability and thermal stability. Both in vitro and in vivo experiments show that the as-obtained UPI can ablate the cancer cells effectively with 808 nm irradiation, revealing their great potential as NIR-mediated dual-modal therapeutic platform. Meanwhile, the core of UCNPs can be used for UCL imaging. All these results demonstrate great potentiality of UPI as a new kind of novel theranostic agents for the treatment of tumors. Figure 6. (a) Representative photographs of temperature change behavior of UPI aqueous solution under different 808 nm irradiation times. (b) Infrared thermal images of tumor-bearing mice injected with saline or UPI solutions exposed to the 808 nm laser recorded at different time intervals, respectively.Figure 7.(a) Representative photographs of mice after different intratumoral treatments: Control group, 808 nm laser irradition only and UPI exposed to 808 nm light, respectively. The body weights (b) and the relative tumor volumes (c) of mice after the treatment with PBS as control, Only NIR, Pure ICG, UPI, ICG+NIR and UPI+NIR, respectively. Mean tumor weights (d) and photographs (e) of excised tumors with different treatments at the last day of experiments. (f) Haematoxylin and eosin (H&E) staining of tumor slices for control, UPI and UPI+NIR groups, respectively.

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“…Magnetic nanoparticles carrying the PS can be attracted by the magnetic field during the bloodstream circulation and retained in the external magnetic field applied site. Magnetic field-guided PDT 106 , 107 and PTT 108 - 113 have been studied successfully by various groups. Superparamagnetic Fe 3 O 4 has been used with Prussian blue dye to create nanoparticles for magnetically-targeted PTT 112 .…”

Section: Targeting Mechanismsmentioning

confidence: 99%

Targeted Nanomaterials for Phototherapy

2017

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Phototherapies involve the irradiation of target tissues with light. To further enhance selectivity and potency, numerous molecularly targeted photosensitizers and photoactive nanoparticles have been developed. Active targeting typically involves harnessing the affinity between a ligand and a cell surface receptor for improved accumulation in the targeted tissue. Targeting ligands including peptides, proteins, aptamers and small molecules have been explored for phototherapy. In this review, recent examples of targeted nanomaterials used in phototherapy are summarized.

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Magnetite nanocluster@poly(dopamine)-PEG@ indocyanine green nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo

Cited by 53 publications

References 36 publications

Indocyanine green-incorporating nanoparticles for cancer theranostics

Indocyanine green-incorporating nanoparticles for cancer theranostics

Multifunctional UCNPs@PDA-ICG nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy

Targeted Nanomaterials for Phototherapy

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