Indocyanine green-incorporating nanoparticles for cancer theranostics

Wang, Haolu; Li, Xinxing; Tse, Brian Wan-Chi; Yang, Haotian; Thorling, Camilla A.; Liu, Yuxin; Touraud, Margaux; Chouane, Jean Batiste; Liu, Xin; Roberts, Michael S.; Liang, Xiaowen

doi:10.7150/thno.22872

Cited by 277 publications

(192 citation statements)

References 90 publications

(135 reference statements)

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“…In recent years, PTT has gained remarkable popularity for cancer treatment due to its non‐invasiveness, high accuracy and safety . PTT utilizes photosensitizing agents to generate hyperthermia through converting excitation energy into thermal energy and results in thermal ablation of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water‐responsive phospholipid‐calcium‐carbonate hybrid nanoparticle (PL/ACC‐DOX&ICG) surface modified with a phospholipid shell is designed and covered with a shielding polymer polyethylene glycol; this development is loaded with the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) for near‐infrared (NIR) imaging and chemophotothermal combination therapy against breast cancer. PL/ACC‐DOX&ICG exhibits satisfactory stability against various aqueous environments with minimal drug leakage and can readily decompose to facilitate quick drug release into cancer cells. In vivo biodistribution studies, PL/ACC‐DOX&ICG demonstrated strong tumor‐homing properties. Interestingly, the in vitro cellular uptake and intratumoral penetration depth of PL/ACC‐DOX&ICG are significantly enhanced under NIR laser irradiation, owing to ICG‐induced hyperthermia, which not only enhances cell permeability and fluidity but also disrupts the dense tumor extracellular matrix. Compared to chemotherapy or photothermal therapy alone, chemophotothermal combination therapy synergistically induces apoptosis and death in 4T1 cells. Moreover, compared with the phosphate buffer saline group, the combined treatment suppress primary tumor growth at a rate of approximately 94.88% and decrease the number of metastatic nodules by about 93.6%. Therefore, PL/ACC‐DOX&ICG may be a promising nanoplatform for breast cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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“…As the feed DSPE‐PEG‐bio/EXO protein weight ratios increased, the DSPE‐PEG‐bio (nmol)/EXO protein (mg) amounts were calculated to be 12.37 ± 2.62, 25.33 ± 2.79, 106.58 ± 14.92, and 254.00 ± 15.94 nmol mg −1 , respectively. In the presence of ICG, a slightly less amount of DSPE‐PEG‐bio was incorporated into the EXO probably due to the competitive hydrophobic interactions between ICG and DSPE (Figure b). The degree of PEGylation onto the EXO was increased as the feed amount of DSPE‐PEG‐bio increased.…”

Section: Resultsmentioning

confidence: 99%

Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation

Choi

Song

Kang

et al. 2019

Macromolecular Bioscience

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The surface of bovine serum‐derived exosomes (EXOs) are modified with α‐d‐mannose for facile interaction with mannose receptors on dendritic cells (DCs) and for efficient delivery of immune stimulators to the DCs. The surface of the EXOs is modified with polyethylene glycol (PEG) without particle aggregation (≈50 nm) via the incorporation of 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine (DSPE) into the lipid layer of the EXO, compared to chemical conjugation by N‐hydroxysuccinimide activated PEG (NHS‐PEG). PEG modification onto the exosomal surface significantly decreases the non‐specific cellular uptake of the EXOs into the DCs. However, the EXOs with mannose‐conjugated PEG‐DSPE (EXO‐PEG‐man) exhibit excellent intracellular uptake into the DCs and boost the immune response by the incorporation of adjuvant, monophosphoryl lipid A (MPLA) within the EXO. After an intradermal injection, a higher retention of EXO‐PEG‐man is observed in the lymph nodes, which could be used for the efficient delivery of immune stimulators and antigens to the lymph nodes in vivo.

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“…Research in organic NPs for image‐guided theranostics has focused on overcoming the intrinsic limitations of fluorescent dyes (poor stability, high susceptibility to photobleaching, low tumor targeting capability) by loading them into suitable carriers . As an FDA‐approved dye, ICG has received the most attention, and multiple works have reported on successful fluorescence‐guided PTT in mouse models using theranostic ICG‐based nanoplatforms . These include ICG‐loaded lipid carriers, hybrid lipid–polymer NPs, hollow silica NPs, carbon‐based systems, or metal organic frameworks .…”

Section: Nanomaterials For Fluorescence‐guided Theranostics: Single‐mmentioning

confidence: 99%

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Rosal

Jia

Jaque

2018

Adv Funct Materials

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Nanoparticles (NPs) have attracted great attention for cancer diagnosis and therapy thanks to their unique properties that enable specific tumor uptake, image-guided diagnosis, and tumor suppression triggered by one or more therapeutic modalities. Light-activated NPs have gained particular interest as minimally invasive theranostic agents for fluorescence-guided tumor diagnosis and highly selective phototherapy. The most recent advances in the field focus on shifting their spectral operation range to the second biological window (1000-1400 nm), while improving their efficacy, selectivity, and multifunctionality. In the past few years, multiple systems capable of light-triggered tumor diagnosis through fluorescence imaging (and in many cases, other imaging modalities) and subsequent tumor therapy have been synthesized and evaluated in small animal models. This review summarizes the different approaches for in vivo tumor theranostics, highlighting their advantages and limitations, and provides a critical analysis of the current state of the field.

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Indocyanine green-incorporating nanoparticles for cancer theranostics

Cited by 277 publications

References 90 publications

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

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