Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Rosal, Blanca del; Jia, Baohua; Jaque, Daniel

doi:10.1002/adfm.201803733

Cited by 59 publications

(28 citation statements)

References 160 publications

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“…This activates the PSs and endow PDT with higher tissue penetrability. [ 193 ] In our ongoing study, under NIR irritation, UCNPs converted NIR to UV–visible light, which irritated the graphite phase carbon nitride (g‐C 3 N 4 ) to generate ROS and emit 570 nm red light. Interestingly, the emitted 570 nm red light of g‐C 3 N 4 could irritate phycocyanin (PC) to generate ROS.…”

Section: Applications In Nanomedicinementioning

confidence: 99%

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Zhao

Zhang

Yang

et al. 2020

Adv Healthcare Materials

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With the rapid advancements in nanotechnology and materials science, numerous nanomaterials have been used as catalysts for nanomedical applications. Their design and modification according to the microenvironment of diseases have been shown to achieve effective treatment. Chemists are in pursuit of nanocatalysts that are more efficient, controllable, and less toxic by developing innovative synthetic technologies and improving existing ones. Recently, single-atom catalysts (SACs) with excellent catalytic activity and high selectivity have attracted increasing attention because of their accurate design as nanomaterials at the atomic level, thereby highlighting their potential for nanomedical applications. In this review, the recent advances in nanocatalysts and SACs are briefly summarized according to their synthesis, characterizations, catalytic mechanisms, and nanomedical applications. The opportunities and future scope for their development and the issues and challenges for their application as nanomedicine are also discussed. As far as it is known, the review is the systematic comparison of nanocatalysts and SACs, especially in the field of nanomedicine, which has promoted the development of nanocatalytic medicine.

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Section: Applications In Nanomedicinementioning

confidence: 99%

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Zhao

Zhang

Yang

et al. 2020

Adv Healthcare Materials

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“…In both therapies, PDT and PTT, particular properties in their active agents are required, as well as robust responses to light stimuli. Furthermore, high specificity, biocompatibility, low dark toxicity, and optical characteristics are desirable [ 22 ]. On this basis, carbon-based materials (CBM) have become excellent candidates as phototherapy agents and as platforms or carriers of these compounds [ 17 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos

Buzzá

Bagnato

et al. 2021

IJMS

120

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Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of therapeutic materials against cancer. This review summarizes the progress made in recent years regarding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced antitumor action by improving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies.

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“…1 Over the past few decades, optical manipulation also ignited greater interest for applications in the medical field including local diagnosis, in vivo imaging, and phototherapy due to its minimal invasion and high spatiotemporal selectivity. [2][3][4][5][6] In particular, the exploration of near-infrared (NIR) light in biological applications is gaining strong momentum, and more than 3000 achievements regarding NIR phototherapy were found in the past three years (Fig. 1A).…”

Section: Introductionmentioning

confidence: 99%