Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos, Karina J.; Buzzá, Hilde Harb; Bagnato, Vanderlei Salvador; Romero, María Paulina

doi:10.3390/ijms23010022

Cited by 105 publications

(27 citation statements)

References 151 publications

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“…PTAs include inorganic materials and organic materials. Inorganic materials include noble metals (e.g., gold nanoparticles and platinum nanoparticles) [ 43 , 44 ], carbon-based nanomaterials (e.g., carbon nanotubes, graphene, graphene oxide, carbon quantum dots, and mesoporous carbon) [ 40 , 45 , 46 , 47 ]. Organic materials include NIR-responsive small molecules and semiconducting polymer nanoparticles [ 48 , 49 , 50 ] (e.g., cyanine, porphyrin, copper phthalocyanine, and diketone pyrrole pyrrole).…”

Section: Photothermal Transduction Agentsmentioning

confidence: 99%

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

Cheng

et al. 2022

IJMS

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As a new tumor treatment strategy, photothermal therapy (PTT) has the advantages of accuracy, ease of administration, a high efficiency and low side effects. Photothermal transduction agents (PTAs) are the key factor which play an important role in PTT. The mechanism of PTT is discussed in detail. The photothermal conversion efficiency (PCE) can be improved by increasing the light absorption and reducing the light scattering of photothermal conversion agents. Additionally, non-radiative relaxation path attenuation can also promote energy conversion to obtain a higher value in terms of PCE. The structure and photothermal characteristics of various kinds of PTAs (metal materials, carbon-based nanomaterials, two-dimensional nanomaterials, and organic materials) were compared and analyzed. This paper reviews the antitumor applications of photothermal synergistic therapies, including PTT combined with immunotherapy, chemotherapy, and photodynamic therapy. This review proposes that these PTAs promote the development of photothermal synergistic therapies and have a great potential in the application of tumor treatment.

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Section: Photothermal Transduction Agentsmentioning

confidence: 99%

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

Cheng

et al. 2022

IJMS

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“…Photothermal agents (PTAs) refer to materials capable of converting light to heat and are the key functional component of PTT nanoplatforms [ 3 , 20 ]. As the light at near infra-red I (NIR-I, 750–850 nm) and NIR-II (900–1200 nm) regions are considered safe windows for clinical treatment by the US Food and Drug Administration, various materials, including gold nanomaterials, 2-D materials, carbon nanomaterials, and conducting polymers were heavily investigated as NIR-I and/or NIR-II PTAs for anti-tumor PTT [ 21 , 22 , 23 , 24 ]. Note that the NIR-II region is believed to be less of an irritant and more transparent than the NIR-I region; as a result, PTAs with high NIR-II photothermal conversion efficiency (PCE) are drawing more and more attention.…”

Section: Cd-based Nanoplatforms For Ptt and Its Combined Therapiesmentioning

confidence: 99%

Cyclodextrin-Based Nanoplatforms for Tumor Phototherapy: An Update

Chen

Guo

et al. 2022

Pharmaceutics

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Tumor phototherapies are light-mediated tumor treatment modalities, which usually refer to tumor photothermal therapy (PTT) and photodynamic therapy (PDT). Due to the outstanding spatial-temporal control over treatment through light irradiation, tumor phototherapies display extremely low side effects during treatment and are believed to be a tumor treatment method with a clinical translation potential. However, current tumor phototherapy nanoplatforms face obstacles, including light irradiation-induced skin burning, tumor hypoxia microenvironments, limited light penetration depth, et al. Therefore, one important research direction is developing a tumor phototherapy nanoplatform with multifunctionality and enhanced pharmacological effects to overcome the complexity of tumor treatment. On the other hand, cyclodextrins (CDs) are starch-originated circular oligosaccharides with negligible toxicity and have been used to form supermolecular nanostructures through a host–guest interaction between the inner cavity of CDs and functional biomolecules. In the past few years, numerous studies have focused on CD-based multifunctional tumor phototherapy nanoplatforms with an enhanced photoeffect, responsive morphological transformation, and elevated drug bioavailability. This review focuses on the preparation methods of CD-based tumor phototherapy nanoplatforms and their unique physiochemical properties for improving anti-tumor pharmacological efficacy.

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“…Carbon-based nanomaterials (e.g., carbon nanotubes (CNTs), quantum dots (QDs), nanodiamonds (NDs), and graphene oxide (GO)) have widely been exploited for various biomedical applications, including biosensors, drug delivery, tissue engineering, imaging, and cancer therapy [ 31 , 32 , 33 , 34 ]. Among these nanomaterials, a two-dimensional (2D) GO has gained tremendous attention as a drug carrier and an NIR-mediated photothermal agent for cancer treatment due to its excellent electronic, physicochemical, and optical properties [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light-Triggered Generation of Reactive Oxygen Species and Induction of Local Hyperthermia from Indocyanine Green Encapsulated Mesoporous Silica-Coated Graphene Oxide for Colorectal Cancer Therapy

et al. 2022

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Near-infrared (NIR) light-mediated photothermal therapy (PTT) and photodynamic therapy (PDT) have widely been used for cancer treatment applications. However, a number of limitations (e.g., low NIR absorption capacity of photothermal agents, insufficient loading efficiency of photosensitive molecules) have hindered the widespread use of NIR-mediated cancer therapy. Therefore, we developed a mesoporous silica-coated reduced graphene oxide (rGO) nanocomposite that could provide a high encapsulation rate of indocyanine green (ICG) and enhance PTT/PDT efficiency in vitro and in vivo. The ICG-encapsulated nanocomposite not only enhances the photothermal effect but also generates a large number of tumor toxic reactive oxygen species (ROS). By conjugation of polyethylene glycol (PEG) with folic acid (FA) as a tumor targeting moiety, we confirmed that ICG-encapsulated mesoporous silica (MS)-coated rGO nanocomposite (ICG@MS-rGO-FA) exhibited high colloidal stability and intracellular uptake in folate receptor-expressing CT-26 colorectal cancer cells. Upon NIR laser irradiation, this ICG@MS-rGO-FA nanocomposite induced the apoptosis of only CT-26 cells via enhanced PTT and PDT effects without any damage to normal cells. Furthermore, the ICG@MS-rGO-FA nanocomposite revealed satisfactory tumor targeting and biocompatibility in CT-26 tumor-bearing mice, thereby enhancing the therapeutic effects of PTT and PDT in vivo. Therefore, this tumor-targeted ICG@MS-rGO-FA nanocomposite shows a great potential for phototherapy applications.

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Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Cited by 105 publications

References 151 publications

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

Antitumor Applications of Photothermal Agents and Photothermal Synergistic Therapies

Cyclodextrin-Based Nanoplatforms for Tumor Phototherapy: An Update

Near-Infrared Light-Triggered Generation of Reactive Oxygen Species and Induction of Local Hyperthermia from Indocyanine Green Encapsulated Mesoporous Silica-Coated Graphene Oxide for Colorectal Cancer Therapy

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