Magnetically guided delivery of DHA and Fe ions for enhanced cancer therapy based on pH-responsive degradation of DHA-loaded Fe 3 O 4 @C@MIL-100(Fe) nanoparticles

Wang, Dongdong; Zhang, Jiajia; Chen, Ruhui; Shi, Ruohong; Xia, Guoliang; Zhou, Shuangliu; Liu, Zhenbang; Zhang, NianQing; Wang, Haibao; Guo, Zhen; Chen, Qianwang

doi:10.1016/j.biomaterials.2016.08.039

Cited by 200 publications

(128 citation statements)

References 61 publications

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“…[29] Fori nstance,o ur group synthesized amorphous Fe 0 nanoparticles (AFeNPs) (Figure 1a), [25] which were rapidly ionized in an acidic TME to release more Fe 2+ ions than Fe 0 nanocrystals (FeNCs) for CDT because it had the reactive nature of metallic glasses.A sp resented in Figure 1b,c, the release rate of ferrous ions from the AFeNPs reached 57 %at ap Ho f6 .5 and 100 %a tapH of 5.4 within 6h,w hich were much higher than those observed for the FeNCs.M oreover, both AFeNPs and FeNCs tended to slowly release ferrous ions at aneutral pH. These results confirmed the capacity of AFeNPs for selective ferrous ion release,t hus ensuring the efficiency of CDT.I na ddition, many other iron-based nanomaterials,i ncluding Fe oxides, [30][31][32] [FeO(OH) n ], [33] and M(Sn,Mn)Fe 2 O 4 [34,35] have also been introduced as CDT agents,b ut none have focused on increasing the release of the catalytic Fe 2+ ions.…”

Section: Iron-based Inorganic Nanomaterialssupporting

confidence: 54%

Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions

et al. 2018

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Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.

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Section: Iron-based Inorganic Nanomaterialssupporting

confidence: 54%

Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions

et al. 2018

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“…have been used to carry small‐molecule theranostic agents. [ 20,31–34 ] Moreover, porphyrin‐based MOFs have been widely used as NTAs for fluorescence imaging and PDT in tumor therapy. [ 28,35–38 ] Compared to small‐molecule theranostic agents, NTAs composed of MOF nanomaterials demonstrate stronger tumor retention with an enhanced permeability and retention (EPR) effect.…”

Section: Methodsmentioning

confidence: 99%

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Chen

Pan

et al. 2020

Advanced Materials

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Nanotheranostic agents (NTAs) that integrate diagnostic capabilities and therapeutic functions have great potential for personalized medicine, yet poor tumor specificity severely restricts further clinical applications of NTAs. Here, a pro‐NTA (precursor of nanotheranostic agent) activation strategy is reported for in situ NTA synthesis at tumor tissues to enhance the specificity of tumor therapy. This pro‐NTA, also called PBAM, is composed of an MIL‐100 (Fe)‐coated Prussian blue (PB) analogue (K2Mn[Fe(CN)6]) with negligible absorption in the near‐infrared region and spatial confinement of Mn2+ ions. In a mildly acidic tumor microenvironment (TME), PBAM can be specifically activated to synthesize the photothermal agent PB nanoparticles, with release of free Mn2+ ions due to the internal fast ion exchange, resulting in the “ON” state of both T1‐weighted magnetic resonance imaging and photoacoustic signals. In addition, the combined Mn2+‐mediated chemodynamic therapy in the TME and PB‐mediated photothermal therapy guarantee a more efficient therapeutic performance compared to monotherapy. In vivo data further show that the pro‐NTA activation strategy could selectively brighten solid tumors and detect invisible lymph node metastases with high specificity.

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“…Another interesting study for the multifunctional magnetic core–shell MOF theranostic platform was reported by Chen and co‐workers . Multifunctional Fe 3 O 4 @C@MIL‐100(Fe) (FCM) nanocomposites were designed for simultaneous delivery of dihydroartemisinin (DHA) and Fe (III) as cancer theranostic nanoplatforms ( Figure a).…”

Section: Multifunctional Mofs For Cancer Theranosticsmentioning

confidence: 99%

Section: Multifunctional Mofs For Cancer Theranosticsmentioning

confidence: 99%

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

2017

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Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.

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Magnetically guided delivery of DHA and Fe ions for enhanced cancer therapy based on pH-responsive degradation of DHA-loaded Fe 3 O 4 @C@MIL-100(Fe) nanoparticles

Cited by 200 publications

References 61 publications

Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions

Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

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