Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

Abstract

Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.

Structure Optimisation of Large Transition‐Metal Complexes with Extended Tight‐Binding Methods

“…In particular,t he treatment of transition metals is limited or even impossible in many SQM methods.T his is contradicting the importance of transition metals in numerous and diverse areas of chemistry,partly involving very large or extended molecular or periodic systems.E xamples are supramolecular organometallic aggregates such as metalorganic polyhedra (MOPs) or macrocycles (MOMs), metalorganic frameworks (MOFs), and metal-containing biomolecules,s uch as metalloproteins or ac ombination to metal-biomolecule frameworks (MBioFs). [16,17] Thep otential field of application for efficient SQM methods is correspondingly large.However,universally applicable methods that are fully parameterised for transition metals are mostly limited to two method families,namely the already frequently used neglect of diatomic differential overlap (NDDO) based PMx (parametric method x)m ethods [4][5][6] and the recently introduced extended tight-binding methods GFNn-xTB, [1,2] (geometries,vibrational frequencies, and noncovalent interactions extended tight binding) from our laboratory.The robustness and quality of the GFNn-xTB methods has already been demonstrated in numerous applications with apredominant focus on organic chemistry.These applications include simulations of electron ionisation mass spectra, [18] fully automated computation of spin-spin-coupled nuclear resonance spectra, [19] including conformer-rotamer ensemble generation, atomic charge generation for the new D4 dispersion correction, [20,21] geometry optimisation of lanthanoid complexes, [22] automated determination of protonation sites, [23] pK a calculation in the SAMPL6 blind challenge, [24] metadynamics-based exploration of chemical compound conformation and reaction space, [25] and few studies on organometallic systems. [16,17] Thep otential field of application for efficient SQM methods is correspondingly large.However,universally applicable methods that are fully parameterised for transition metals are mostly limited to two method families,namely the already frequently used neglect of diatomic differential overlap (NDDO) based PMx (parametric method x)m ethods [4][5][6] and the recently introduced extended tight-binding methods GFNn-xTB, [1,2] (geometries,vibrational frequencies, and noncovalent interactions extended tight binding) from our laboratory.The robustness and quality of the GFNn-xTB methods has already been demonstrated in numerous applications with apredominant focus on organic chemistry.These applications include simulations of elect...…”

Tuning the Structure and Properties of Lanthanoid Coordination Polymers with an Asymmetric Anilato Ligand

“…The modulation and control of the shape and size of the cavities is a key aspect to designing MOFs with tailored properties, for applications in gas storage and separation [3,4], water adsorption [5], energy storage [6,7], catalysis [8,9], sensors [10,11], biomedicine [12,13], or for combining several properties in the same MOF [14].…”

A 12-Fold ThSi2 Interpenetrated Network Utilizing a Glycine-Based Pseudopeptidic Ligand

“…Ever since their popularization in the last decade, coordination polymers (CPs), also known as metal-organic frameworks (MOFs), have become one of the most prominent branches of inorganic and materials chemistry, in no small part due to the extensive variety of their applications [1][2][3][4][5][6][7][8]. A key factor for the rise of CPs as functional materials has been the development of rational synthetic routes towards the optimization of their application potential [9][10][11][12].…”