Magnetic Resonance Imaging of Optic Neuritis in Patients With Neuromyelitis Optica Versus Multiple Sclerosis

Khanna, Sangeeta; Sharma, Aseem; Huecker, Julie; Gordon, Mae O.; Naismith, Robert T.; Stavern, Gregory P. Van

doi:10.1097/wno.0b013e318254c62d

Cited by 143 publications

(100 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mean optic nerve sheath diameter (ONSD) was 5.31±0.48 mm (range, 3.8-6.5) in all MS patients, 5.32±0.39 mm (range, 4.7-6.1) in MS with previous optic neuritis, 5.31±0.51 mm (range, 3.8-6.5) in MS without previous optic neuritis, and 5.22±0.58 mm (range, 3.7-7) in the healthy volunteers. There was no statistically significant difference in the mean thickness of the optic nerve between the MS patients with and without previous optic neuritis (p=0.920), and there was no statistically significant difference in the mean thickness of the optic nerve between all MS patients and healthy volunteers (p=0.205).…”

Section: Resultsmentioning

confidence: 99%

“…Impaired vision is one of the most common symptoms of MS, and the visual system can be affected in all anatomical sites. Of these sites, the optic nerve is the best described, because inflammatory demyelinating optic neuritis may be the initial presenting feature in patients with MS [5,6]. Conventional and non-conventional magnetic resonance imaging (MRI) techniques, such as diffusion tensor imaging, diffusion-weighted imaging, and magnetization transfer imaging are used for the diagnosis of optic neuritis [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects

et al. 2017

View full text Add to dashboard Cite

Aims: Our aim was to evaluate the elasticity features of the optic nerve using strain (SE) and shear wave elastography (SWE) in multiple sclerosis (MS) patients in comparison with healthy subjects. Material and methods: One hundred and seven optic nerves from 54 MS patients and 118 optic nerves from 59 healthy subjects were examined prospectively by SE and SWE. Optic nerves were divided into three types in accordance to the elasticity designs, as follows: type 1 predominantly blue (hardest tissue); type 2 predominantly blue/green (hard tissue); and type 3 predominantly green (intermediate tissue). Quantitative measurements of optic nerve hardness with SWE were analyzed in kilopascals. Results: Elastographic images from healthy volunteers showed mostly type 3 optic nerves (61.9%); type 2 was also found (38.1%), but type 1 was not observed. Elastographic examination of MS patients showed mostly type 2 optic nerves (88%), while some type 1 (4.6%) and type 3 optic nerves (6.5%) were rarely observed. There was a statistically significant difference in terms of elasticity patterns between patients and healthy volunteers (p<0.001). Statistically significant differences were observed between patients and healthy volunteers in the analysis of SWE values (10.381±3.48 kPa and 33.87±11.64 p<0.001). The receiver operating characteristic curve analysis was perfect (0.993; 95% confidence interval [CI]=0.971–0.999), and a cut-off value of 18.3 kPa shear had very high sensitivity and specificity for the patient group. No significant differences were observed between patients with and without previous optic neuritis. Conclusion: SE and SWE examination findings concerning the optic nerve in MS patients demonstrated remarkable differences according to the healthy group.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recent studies have looked at the differential MRI features of the optic nerve lesion between MS and NMOSD. 32,33 A trend to more posterior involvement of the optic nerve including chiasm, and simultaneous bilateral disease, has been observed in NMOSD ( figure 3). 32,33 Thus, long-segment inflammation of the optic nerve, particularly when simultaneous bilateral and extending posteriorly into the optic chiasm, should lead us to suspect the diagnosis of NMOSD in the appropriate clinical context.…”

Section: E16mentioning

confidence: 99%

MRI characteristics of neuromyelitis optica spectrum disorder

et al. 2015

View full text Add to dashboard Cite

Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to involve only the optic nerves and spinal cord. However, the discovery of highly specific antiaquaporin-4 antibody diagnostic biomarker for NMO enabled recognition of more diverse clinical spectrum of manifestations. Brain MRI abnormalities in patients seropositive for anti-aquaporin-4 antibody are common and some may be relatively unique by virtue of localization and configuration. Some seropositive patients present with brain involvement during their first attack and/or continue to relapse in the same location without optic nerve and spinal cord involvement. Thus, characteristics of brain abnormalities in such patients have become of increased interest. In this regard, MRI has an increasingly important role in the differential diagnosis of NMO and its spectrum disorder (NMOSD), particularly from multiple sclerosis. Differentiating these conditions is of prime importance because early initiation of effective immunosuppressive therapy is the key to preventing attack-related disability in NMOSD, whereas some disease-modifying drugs for multiple sclerosis may exacerbate the disease. Therefore, identifying the MRI features suggestive of NMOSD has diagnostic and prognostic implications. We herein review the brain, optic nerve, and spinal cord MRI findings of NMOSD. Neuromyelitis optica (NMO) is an inflammatory disease of the CNS that is characterized by severe attacks of optic neuritis (ON) and longitudinally extensive transverse myelitis (LETM). 1The past decade has witnessed dramatic advances in our understanding of NMO. Such advances were initiated by the discovery of the disease-specific autoantibody, NMO-immunoglobulin G (NMO-IgG), and subsequent identification of the main target autoantigen, aquaporin-4 (AQP4), which has distinguished NMO as a distinct disease from multiple sclerosis (MS). 2Current diagnostic criteria, however, still require both ON and myelitis for an NMO diagnosis.3 Nevertheless, the identification of anti-AQP4 antibodies beyond the current diagnostic criteria of NMO indicates a broader clinical phenotype of this disorder, so-called "NMO spectrum disorder" (NMOSD). 4,5 The NMOSD encompasses anti-AQP4 antibody seropositive patients with limited or inaugural forms of NMO and with specific brain abnormalities. It also includes anti-AQP4 antibody seropositive patients with other autoimmune disorders such as systemic

show abstract

“…Especially contrast enhanced T 1 w images can demonstrate subtle enhancement indicating an active inflammatory process (Kollia et al, 2009). In combination with high resolution diffusion tensor imaging (Wargo and Gore, 2013) this may facilitate qualitative and quantitative assessment of optic nerve involvement in these patients and may improve differential diagnosis of optic neuropathies (Erb-Eigner et al, 2013b;Khanna et al, 2012).…”

Section: Resultsmentioning

confidence: 98%

High spatial resolution in vivo magnetic resonance imaging of the human eye, orbit, nervus opticus and optic nerve sheath at 7.0 Tesla

Lindner¹,

Langner

Graessl

et al. 2014

Experimental Eye Research

View full text Add to dashboard Cite

Magnetic Resonance Imaging of Optic Neuritis in Patients With Neuromyelitis Optica Versus Multiple Sclerosis

Abstract: We found a higher propensity of NMO-related ON to affect more posterior parts of the optic nerve, including chiasm, and have simultaneous bilateral disease. Further study with larger sample sizes is needed.

Cited by 143 publications

References 12 publications

Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects

Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects

MRI characteristics of neuromyelitis optica spectrum disorder

High spatial resolution in vivo magnetic resonance imaging of the human eye, orbit, nervus opticus and optic nerve sheath at 7.0 Tesla

Contact Info

Product

Resources

About