High spatial resolution in vivo magnetic resonance imaging of the human eye, orbit, nervus opticus and optic nerve sheath at 7.0 Tesla

Lindner, Tobias; Langner, Soenke; Graessl, Andreas; Rieger, Jan; Schwerter, Michael; Muhle, Max; Lysiak, Darius; Kraus, Oliver; Wuerfel, Jens; Guthoff, Rudolf; Falke, Karen; Hadlich, Stefan; Krüger, Paul-Christian; Hosten, Norbert; Niendorf, Thoralf; Stachs, Oliver

doi:10.1016/j.exer.2014.05.017

Cited by 33 publications

(26 citation statements)

References 42 publications

(48 reference statements)

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“…By taking advantage of the good coil filling factor and non-isotropic sampling (e.g., thick slices), fine resolution images, approaching those in rodents, but in humans without sedation is possible using a cuedblinking procedure (Beenakker et al, 2013(Beenakker et al, , 2015Berkowitz et al, 2001;Berkowitz et al, 2013;Lindner et al, 2014;Sirin et al, 2015;Zhang et al, 2011). For example, we recently published human images collected at 58 mm axial resolution .…”

Section: Addressing Concerns About Memri and Mrimentioning

confidence: 97%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

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Section: Addressing Concerns About Memri and Mrimentioning

confidence: 97%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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“…Extended scanning times in our case were related to using large-bore gradient and radiofrequency coils and the development of globe imaging protocols, as this was the first 7-tesla MRI performed on a globe at our institution. Beenakker et al [3] and Lindner et al [6] have previously demonstrated submillimeter resolution of the globe with 3- and 2.5-min acquisition times, respectively, using custom-designed dedicated eye coils. Although 7-tesla MRI of the optic nerve has been described previously [6], to our knowledge, our report is the first attempt at histopathologic correlation.…”

Section: Discussionmentioning

confidence: 99%

“…Beenakker et al [3] and Lindner et al [6] have previously demonstrated submillimeter resolution of the globe with 3- and 2.5-min acquisition times, respectively, using custom-designed dedicated eye coils. Although 7-tesla MRI of the optic nerve has been described previously [6], to our knowledge, our report is the first attempt at histopathologic correlation. Our case demonstrates the potential to document the existence of optic nerve invasion in the presence of an intraocular tumor, a feature that has a major bearing on decision making particularly for consideration of enucleation.…”

Section: Discussionmentioning

confidence: 99%

“…Ultrahigh-field MRI such as 7 T affords a submillimeter spatial resolution and improved signal-to-noise ratios when compared to lower-field strength MRI commonly available at most institutions [6]. Recent attempts to increase the resolution for in vivo imaging have included the use of 7-tesla MRI with a custom-designed coil array that are expensive and are sensitive to motion artifacts [3].…”

Section: Discussionmentioning

confidence: 99%

“…Recent attempts to increase the resolution for in vivo imaging have included the use of 7-tesla MRI with a custom-designed coil array that are expensive and are sensitive to motion artifacts [3]. Optoacoustic triggering schemes and normalization of imaging parameters such as pulse repetition time, echo time, bandwidth, and reconstruction matrix can overcome such limitations and provide high-resolution images of the optic nerve from the disc to the orbital apex [2,6]. …”

Section: Discussionmentioning

confidence: 99%

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Optic Nerve Assessment Using 7-Tesla Magnetic Resonance Imaging

Singh¹,

Platt²,

Lystad³

et al. 2016

Ocul Oncol Pathol

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Purpose: The purpose of this study was to correlate high-resolution magnetic resonance imaging (MRI) and histologic findings in a case of juxtapapillary choroidal melanoma with clinical evidence of optic nerve invasion. Methods: With institutional review board approval, an enucleated globe with choroidal melanoma and optic nerve invasion was imaged using a 7-tesla MRI followed by histopathologic evaluation. Results: Optical coherence tomography, B-scan ultrasonography, and 1.5-tesla MRI of the orbit (1-mm sections) could not detect optic disc invasion. Ex vivo, 7-tesla MRI detected optic nerve invasion, which correlated with histopathologic features. Conclusions: Our case demonstrates the potential to document the existence of optic nerve invasion in the presence of an intraocular tumor, a feature that has a major bearing on decision making, particularly for consideration of enucleation.

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A Comparison of 3 T and 7 T MRI for the Clinical Evaluation of Uveal Melanoma

Tang

Jaarsma-Coes

Ferreira

et al. 2021

Magnetic Resonance Imaging

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Background Magnetic resonance imaging (MRI) is increasingly being used in the diagnosis and treatment planning of uveal melanoma (UM), the most common primary intraocular tumor. Initially, 7 T MRI was primarily used, but more recently these techniques have been translated to 3 T, as it is more commonly available. Purpose Compare the diagnostic performance of 3 T and 7 T MRI of UM. Study Type Prospective. Population Twenty‐seven UM patients (19% female). Field Strength/Sequence 3 T: T1‐ and T2‐weighted three‐dimensional (3D) spin echo (SE) and multi‐slice (MS) SE, 7 T: T1‐weighted 3D gradient echo (GE), T2‐weighted 3D SE and MS SE, 3 T and 7 T GE dynamic contrast‐enhanced. T1 weighted images: acquired before and after Gadolinium (Gd) administration. Assessment For all sequences, scan and diagnostic quality was quantified using a 5‐point Likert scale. Signal intensities on T1 and T2 relative to choroid and eye muscle respectively were assessed as well as the tumor prominence. Finally, the perfusion time‐intensity curves (TICs) were classified as plateau, progressive, or wash‐out. Statistical Tests Image quality scores were compared between both field strengths using Wilcoxon signed‐rank and McNemar tests. Paired t‐tests and Bland–Altman were used for comparing tumor prominences. P < 0.05 was considered statistically significant. Results Image quality was comparable between 3 T and 7 T, for 3DT1, 3DT2, 3DT1Gd (P = 0.86; P = 0.34; P = 0.78, respectively) and measuring tumor dimensions (P = 0.40). 2DT1 and 2DT2 image quality were rated better on 3 T compared to 7 T. Most UM had the same relative signal intensities at 3 T and 7 T on T1 (17/21) and T2 (13/17), and 16/18 diagnostic TICs received the same classification. Tumor prominence measurements were similar between field strengths (95% confidence interval: −0.37 mm to 0.03 mm, P = 0.097). Data Conclusion Diagnostic performance of the evaluated 3 T protocol proved to be as capable as 7 T, with the addition of 3 T being superior in assessing tumor growth into nearby anatomical structures compared to 7 T. Level of Evidence 2 Technical Efficacy Stage 3

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High spatial resolution in vivo magnetic resonance imaging of the human eye, orbit, nervus opticus and optic nerve sheath at 7.0 Tesla

Cited by 33 publications

References 42 publications

MRI of rod cell compartment-specific function in disease and treatment in vivo

MRI of rod cell compartment-specific function in disease and treatment in vivo

Optic Nerve Assessment Using 7-Tesla Magnetic Resonance Imaging

A Comparison of 3 T and 7 T MRI for the Clinical Evaluation of Uveal Melanoma

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