Magnetic Resonance Imaging in Postprostatectomy Radiotherapy Planning

Sefrova, Jana; Odrážka, Karel; Paluska, Petr; Bëlobrádek, Z; Broďák, Miloš; Doležel, Martin; Prošvic, Petr; Macingova, Z.; Vošmik, Milan; Hoffmann, Petr; Louda, Miroslav; Nejedla, Anna

doi:10.1016/j.ijrobp.2010.11.004

Cited by 21 publications

(23 citation statements)

References 22 publications

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“…The changes in target volume in this study are in agreement with several other studies [2][3][4][5][6][7], which have demonstrated that outlining prostate and seminal vesicles using MRI results in smaller volumes and anatomically more accurate delineation. One study [7] has shown that outlining with MRI results in a smaller volume of rectal wall being included, potentially leading to a reduced risk of late toxicity.…”

Section: Discussionsupporting

confidence: 92%

“…MRI has reduced interference from metal implants such as prosthetic hips [2] and gold seed implants and therefore has the potential to provide improved target volume delineation over CT. Changes in anatomical and tumour definition as a result of using MRI data compared with CT have been reported for prostate [2][3][4][5][6][7], head and neck [8][9][10][11] and brain cancer [12,13] patients.…”

mentioning

confidence: 99%

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The influence of MRI scan position on image registration accuracy, target delineation and calculated dose in prostatic radiotherapy

Hanvey¹,

Sadozye²,

McJury³

et al. 2012

BJR

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Objective: To investigate the necessity of performing MRI in the radiotherapy position when using MRI for prostatic radiotherapy. Methods: 20 prostate patients received a CT, diagnostic MRI and an MRI scan in the radiotherapy position. The quality of registration between CT and MRI was compared between the two MRI set-ups. The prostate and seminal vesicles were contoured using all scans and intensity modulated radiotherapy (IMRT) plans were generated. Changes in the target volume and IMRT plans were investigated. Two-tailed paired Student's ttests determined the statistical significance.Results: There was a decrease in the mean distance from the centre of the bony anatomy between CT and MRI (from 3.9 to 1.9 mm, p-value,0.0001) when the MRI scan was acquired in the radiotherapy position. Assuming that registering CT with an MRI scan in the radiotherapy position is the gold standard for delineating the prostate and seminal vesicles, using a planning target volume delineated on the CT with a diagnostic MRI scan viewed separately, resulted in a mean conformation number of 0.80 instead of the expected 0.98 (p,0.0001). Conclusion: By registering CT with an MRI scan in the radiotherapy position, there is a statistically significant improvement in the registration and IMRT quality. Advances in knowledge: To achieve an acceptable registration and IMRT quality in prostatic radiotherapy, neither CT with a separate diagnostic MRI nor CT registered to a diagnostic MRI will suffice. Instead, a CT registered with an MRI in the radiotherapy position should be used.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

The influence of MRI scan position on image registration accuracy, target delineation and calculated dose in prostatic radiotherapy

Hanvey¹,

Sadozye²,

McJury³

et al. 2012

BJR

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show abstract

“…25 Maybe the introduction of MRI in the target definition phase will contribute to perform a better delineation of CTV and OARs. 26,27 Analyzing our toxicity data in correlation with patients' clinical variables, the log-rank test evidenced a protective effect of hormonal therapy on the intestinal tissue (weak correlation), as reported in other studies 28,29 and demonstrated in animal models. 30 We found that antihypertensive medication increases the risk of acute GI toxicity, whereas it seems to have a protective effect in the series by Fellin et al 31 Finally, the use of anticoagulants or antiaggregants is weakly associated to late GI toxicity, as reported by Choe et al 29 and Takeda et al 32 Our Cox proportional hazards regression confirms the relation between dose-volume parameters (maximal dose to the rectum, and bladder V 65 ) and toxicity.…”

Section: Resultssupporting

confidence: 69%

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

Ingrosso

Carosi

Cristino

et al. 2017

Reports of Practical Oncology & Radiotherapy

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“…HI value was obtained usdata sets to take advantage of the superior soft-tissue contrast of MRI and electron density information of CT. [4] Changes in anatomical and tumor definition as a result of using MRI data compared with CT have been reported for prostate patients. [5][6][7][8][9] Studies comparing CT-versus MRI-derived volume found that in general, prostrate volume delineated on CT was approximately 1.3 times larger than MRI-derived volume. [10] This advantage of MRI is based on better soft-tissue visualization and availability of multiplanar image acquisition.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Different Discipline Obtained By Using Drafted Contours Planning Techniques in The Treatment of Prostate Cancer

Çetin¹,

Degerli²,

Ergelen³

et al. 2016

TJ Oncol

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OBJECTIVEThis study is a comparison of contoured diagnostic images derived from computed tomography (CT) and magnetic resonance imaging (MRI) by both a radiation oncologist (RO) and a radiologist (R) using volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT) techniques. METHODSCT and MRI sections of 16 patients were contoured by the RO and the R. Planning target volume (PTV) criteria assessed were conformity index (CI), homogeneity index (HI), volume covered by 98% isodose line (V 98%) and maximum dose (D max ). In critical organs, 40 Gy organ area volume (V 40 ), 65 Gy organ area volume (V 65 ), and D mean criteria were evaluated. Paired samples t-test was used for statistical analysis. RESULTSPTV and critical organs were compared. MRI PTV and bladder volume drawn by R were lower. Comparison of CT images revealed IMRT plans were superior in terms of D max and CI, while V 40 and D mean values for rectum and bladder were lower in MRI-based VMAT plans. In MRI plans, IMRT was superior in terms of PTV, D max , CI, V 65 , and D mean for critical organs; however, critical organs were well preserved with both planning techniques. CONCLUSIONThere was some difference between contouring of the R and the RO, which was reflected in the treatment plans.

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Magnetic Resonance Imaging in Postprostatectomy Radiotherapy Planning

Cited by 21 publications

References 22 publications

The influence of MRI scan position on image registration accuracy, target delineation and calculated dose in prostatic radiotherapy

The influence of MRI scan position on image registration accuracy, target delineation and calculated dose in prostatic radiotherapy

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

Comparison of Two Different Discipline Obtained By Using Drafted Contours Planning Techniques in The Treatment of Prostate Cancer

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