Magnetic Resonance Imaging and Spectroscopy Reveal Differential Hippocampal Changes in Anhedonic and Resilient Subtypes of the Chronic Mild Stress Rat Model

Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats

“…This process is powerfully suppressed by prolonged exposure to corticosterone or to stressors (Petrik, Lagace, & Eisch, 2012), as here observed. These morphological changes are associated with a decrease in the volume of the hippocampus following UCMS (Y Palacios et al, 2011). In the present study we suggest that the decreased hippocampal area of GFAP expression observed in the ED group resulted of the high levels of corticosterone induced by the dentin hypersensitivity associated to UCMS procedure.…”

The Neurobiology of Resilience

“…Abstr., 907. 26,2011 Surprisingly, this current is similarly increased in VTA neurons of resilient mice, suggesting the existence of an additional ionic mechanism, which counteracts the increased I h function and normalizes firing rate in resilient mice. Our early microarray analyses identified large increases in a cluster of K + channel subunits, including KCNF1, KCNH3, KCNK4 and KCNQ3, in the resilient VTA 24 .…”

“…As with humans, chronic stress leads to the development of depression-or anxiety-like behaviors in only a subset of laboratory animals [22][23][24][25][26][27] . The remaining animals, which have been termed resilient in some studies, usually exhibit some deleterious symptoms in response to the stress, but do not exhibit deficits in key behavioral domains.…”

Short photoperiod condition increases susceptibility to stress in adolescent male rats

“…The water and sucrose bottles were weighed to determine sucrose preference. Previous study [20] showed that repeated exposure to mild stressors induces anhedonia in up to 70% of the stress-exposed rats, whereas the remaining show resilience to stress. We referred to the cutoff of sucrose consumption and the anhedonic-like state was defined as a minimum of 40% reduction in sucrose preference in response to stress.…”