Magnetic resonance evaluation of TruFit® plugs for the treatment of osteochondral lesions of the knee shows the poor characteristics of the repair tissue

Gelber, Pablo Eduardo; Batista, Jorge; Millán-Billi, Angélica; Patthauer, Luciano; Vera, Silvia Rivas; Gómez-Masdeu, Mireia; Monllau, Juan Carlos

doi:10.1016/j.knee.2014.04.013

Cited by 25 publications

(24 citation statements)

References 32 publications

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“…T2 mapping of the repair tissue of both treatment groups revealed differences between the repair tissue and the native cartilage, including a lack of the laminar pattern typical of native tissue along with the softer biomechanical properties. These changes are typical of those reported in studies of osteochondral defects repaired with various biological implants 8,44 .…”

Section: Discussionsupporting

confidence: 80%

Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects

Nm³

et al. 2016

The Journal of Bone and Joint Surgery

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Section: Discussionsupporting

confidence: 80%

Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects

Nm³

et al. 2016

The Journal of Bone and Joint Surgery

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“…also including the defect size and type) and after longer course times with clinically established and better evaluated methods [30,39,46,47]. This is especially true as some of the new procedures have not yet demonstrated convincing clinical results despite promising preclinical studies [48,49].…”

Section: Introductionmentioning

confidence: 99%

Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group “Clinical Tissue Regeneration” of the German Society of Orthopaedics and Trauma (DGOU)

Niemeyer

Albrecht

Andereya³

et al. 2016

The Knee

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“…Some studies have shown better clinical, functional and imaging findings at mid to longterm follow-up in the tibio-femoral joint, with a low number of failed cases, [67][68][69] while others have reported minimal clinical improvement, 70 suboptimal MRI results, and a considerable number of failures. 71,72 Future research should invest into randomized comparative clinical studies comparing two or more different techniques with long-term follow-up to ascertain which would be the best surgical approach for patellofemoral chondral defects. Longer follow-up and reporting of MRI results will provide a more detailed picture of the quality of the repaired grafts and how many are eventually converted to arthroplasty.…”

Section: Discussionmentioning

confidence: 99%

Cartilage Restoration of Patellofemoral Lesions: A Systematic Review

et al. 2019

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Purpose This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. Methods This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, EMBASE, and Cochrane Library databases were searched up to August 31, 2018, to identify clinical studies that assessed surgical outcomes of patellofemoral cartilage restoration surgery. The Methodological Index for Non-Randomized Studies (MINORS) was used to assess study quality. Results Forty-two studies were included comprising 1,311 knees (mean age of 33.7 years and 56% males) and 1,309 patellofemoral defects (891 patella, 254 trochlear, 95 bipolar, and 69 multiple defects, including the patella or trochlea) at a mean follow-up of 59.2 months. Restoration techniques included autologous chondrocyte implantation (56%), particulated juvenile allograft cartilage (12%), autologous matrix-induced chondrogenesis (9%), osteochondral autologous transplantation (9%), and osteochondral allograft transplantation (7%). Significant improvement in at least one score was present in almost all studies and these surpassed the minimal clinically important difference threshold. There was a weighted 19%, 35%, and 6% rate of reported complications, reoperations, and failures, respectively. Concomitant patellofemoral surgery (51% of patients) mostly did not lead to statistically different postoperative outcomes. Conclusion Numerous patellofemoral restoration techniques result in significant functional improvement with a low rate of failure. No definitive conclusions could be made to determine the best surgical technique since comparative studies on this topic are rare, and treatment choice should be made according to specific patient and defect characteristics. Level of evidence Level IV, systematic review of level II to IV studies.

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Magnetic resonance evaluation of TruFit® plugs for the treatment of osteochondral lesions of the knee shows the poor characteristics of the repair tissue

Cited by 25 publications

References 32 publications

Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects

Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects

Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group “Clinical Tissue Regeneration” of the German Society of Orthopaedics and Trauma (DGOU)

Cartilage Restoration of Patellofemoral Lesions: A Systematic Review

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