Magnetic Nanoparticles as a Strong Contributor to the Biocompatibility of Ferrogels

Blyakhman, F. A.; Макарова, Е. Б.; Шабадров, П. А.; Fadeyev, F. A.; Shklyar, T. F.; Сафронов, А. П.; Комогорцев, С. В.; Kurlyandskaya, G. V.

doi:10.1134/s0031918x2004002x

Cited by 12 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the same time, it is clearly noticeable that the proliferation substantially increases if MNPs are embedded into PAAm gel matrix (see Figure 10). This result is in good agreement with our previous observations [5,6,37]. However, the underlying reason for such enhancement of proliferation rate by MNPs is not clear yet.…”

Section: Discussionsupporting

confidence: 92%

“…It is well known that both of these factors are strong determinants of the scaffold biocompatibility [36,[39][40][41][42][43]. Previously, we have shown that the addition of MNPs to the PAAm gel network results in significant increase of the Young's modulus [5,37] and contributes to the surface roughness [6] of the PAAm composite material. In this work, we also presented indirect evidence of the existence of MNPs and their aggregates at the surface of ferrogels (see Figure 8).…”

Section: Discussionmentioning

confidence: 93%

“…One of the possible factors is the negative electrical potential of the ferrogel. It was shown earlier [5,37] that the electrical potential of PAAm ferrogel with embedded iron oxide MNPs is around minus 30-40 mV. The electrical potential of a ferrogel originates from the ferrofluid, which is the precursor in the synthesis of ferrogel.…”

Section: Discussionmentioning

confidence: 95%

“…Meanwhile, unlike ferrofluid, MNPs in ferrogel are immobilized and can not leave the gel network. If the electrically charged species are not able to move across the boundary of the gel, it establishes the Donnan equilibrium at the boundary and the resulting Donnan electrical potential [ 5 , 37 , 38 ]. The higher the content of the MNPs, the higher in the Donnan potential.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Constant Magnetic Field to the Proliferation Rate of Human Fibroblasts Grown onto Different Substrates: Tissue Culture Polystyrene, Polyacrylamide Hydrogel and Ferrogels γ-Fe2O3 Magnetic Nanoparticles

et al. 2020

View full text Add to dashboard Cite

The static magnetic field was shown to affect the proliferation, adhesion and differentiation of various types of cells, making it a helpful tool for regenerative medicine, though the mechanism of its impact on cells is not completely understood. In this work, we have designed and tested a magnetic system consisting of an equidistant set of the similar commercial permanent magnets (6 × 4 assay) in order to get insight on the potential of its experimental usage in the biological studies with cells culturing in a magnetic field. Human dermal fibroblasts, which are widely applied in regenerative medicine, were used for the comparative study of their proliferation rate on tissue culture polystyrene (TCPS) and on the polyacrylamide ferrogels with 0.00, 0.63 and 1.19 wt % concentrations of γ-Fe2O3 magnetic nanoparticles obtained by the well-established technique of laser target evaporation. We used either the same batch as in previously performed but different biological experiments or the same fabrication conditions for fabrication of the nanoparticles. This adds special value to the understanding of the mechanisms of nanoparticles contributions to the processes occurring in the living systems in their presence. The magnetic field increased human dermal fibroblast cell proliferation rate on TCPS, but, at the same time, it suppressed the growth of fibroblasts on blank gel and on polyacrylamide ferrogels. However, the proliferation rate of cells on ferrogels positively correlated with the concentration of nanoparticles. Such a dependence was observed both for cell proliferation without the application of the magnetic field and under the exposure to the constant magnetic field.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Constant Magnetic Field to the Proliferation Rate of Human Fibroblasts Grown onto Different Substrates: Tissue Culture Polystyrene, Polyacrylamide Hydrogel and Ferrogels γ-Fe2O3 Magnetic Nanoparticles

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It became clear that the addition of magnetic nanoparticles to the PAAm gel network always resulted in an increase in cell adhesion and proliferation when grown onto the surface of the gel-based composites [ 12 , 13 ]. In particular, the gradual increase in magnetic nanoparticle concentration in PAAm gel from 0 to 2 wt.% was accompanied by the increase in cell monolayer density by a factor of five for the culture grown onto the FG surface [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Properties of Iron Oxide Nanoparticles Do Not Essentially Contribute to Ferrogel Biocompatibility

et al. 2021

View full text Add to dashboard Cite

Two series of composite polyacrylamide (PAAm) gels with embedded superparamagnetic Fe2O3 or diamagnetic Al2O3 nanoparticles were synthesized, aiming to study the direct contribution of the magnetic interactions to the ferrogel biocompatibility. The proliferative activity was estimated for the case of human dermal fibroblast culture grown onto the surfaces of these types of substrates. Spherical non-agglomerated nanoparticles (NPs) of 20–40 nm in diameter were prepared by laser target evaporation (LTE) electrophysical technique. The concentration of the NPs in gel was fixed at 0.0, 0.3, 0.6, or 1.2 wt.%. Mechanical, electrical, and magnetic properties of composite gels were characterized by the dependence of Young’s modulus, electrical potential, magnetization measurements on the content of embedded NPs. The fibroblast monolayer density grown onto the surface of composite substrates was considered as an indicator of the material biocompatibility after 96 h of incubation. Regardless of the superparamagnetic or diamagnetic nature of nanoparticles, the increase in their concentration in the PAAm composite provided a parallel increase in the cell culture proliferation when grown onto the surface of composite substrates. The effects of cell interaction with the nanostructured surface of composites are discussed in order to explain the results.

show abstract

A Review on Hydrogels and Ferrogels for Biomedical Applications

Awasthi

2021

JOM

View full text Add to dashboard Cite

Magnetic Nanoparticles as a Strong Contributor to the Biocompatibility of Ferrogels

Cited by 12 publications

References 17 publications

Effects of Constant Magnetic Field to the Proliferation Rate of Human Fibroblasts Grown onto Different Substrates: Tissue Culture Polystyrene, Polyacrylamide Hydrogel and Ferrogels γ-Fe2O3 Magnetic Nanoparticles

Effects of Constant Magnetic Field to the Proliferation Rate of Human Fibroblasts Grown onto Different Substrates: Tissue Culture Polystyrene, Polyacrylamide Hydrogel and Ferrogels γ-Fe2O3 Magnetic Nanoparticles

Magnetic Properties of Iron Oxide Nanoparticles Do Not Essentially Contribute to Ferrogel Biocompatibility

A Review on Hydrogels and Ferrogels for Biomedical Applications

Contact Info

Product

Resources

About