Magnetic Nanoparticle Hyperthermia in Cancer Treatment: History, Mechanism, Imaging‐Assisted Protocol Design, and Challenges

LeBrun, Alexander; Zhu, Liang

doi:10.1002/9781119127420.ch29

Cited by 20 publications

(29 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TA could release heat due to eddy current loss when exposed to an alternating magnetic field (AMF). In contrast, the synthesized superparamagnetic Fe 3 O 4 nanoparticles generate heat resulting from the Neel relaxation loss due to the rotation of the magnetic moment of the particles [4]. Figure 12 shows that adding Fe 3 O 4 nanoparticles improved the heating performance of the composites.…”

Section: Resultsmentioning

confidence: 99%

“…Magnetic particles generate heat when exposed to an alternating magnetic field (AMF) due to the hysteresis loss and relaxational losses. The hysteresis loss is caused by the orientation of the magnetic moments, in multiple domains particles align continuously with the direction of the AMF [3,4]. On the other hand, relaxational losses occurs mainly in particles with a single magnetic domain and are due to the realignment of particles’ magnetic moments or particles’ attempt to realign themselves with the AMF [3,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electroactive Composites with Block Copolymer-Templated Iron Oxide Nanoparticles for Magnetic Hyperthermia Application

et al. 2019

View full text Add to dashboard Cite

Cancer has been one of the leading causes of human death for centuries. Magnetic hyperthermia is a promising technique to confine and control cancers. However, particles used in magnetic hyperthermia leaking from where the cancers are located could compromise human health. Therefore, we developed electroactive iron oxide/block copolymer composites to tackle the leakage problem. Experimental results show that oleylamine-modified magnetic iron oxide (Fe3O4) particles and electroactive tetraaniline (TA) could be templated in the self-assembled microstructures of sulfonated [styrene-b-(ethylene-ran-butylene)-b-styrene] (S-SEBS) block copolymers. Various amounts of Fe3O4 particles and TA oligomer were incorporated in S-SEBS block copolymer and their electroactive behavior was confirmed by exhibiting two pairs of well-defined anodic and cathodic current peaks in cyclic voltammetry tests. The heating performance of the resultant TA/Fe3O4/polymer composites improved on increasing the added amount of Fe3O4 particles and TA oligomers. Both Fe3O4 and TA can contribute to improved heating performance, but Fe3O4 possesses a greater contribution than TA does. Hence, the main source for increasing the composites’ temperature is Neel relaxation loss from Fe3O4 magnetic particles.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electroactive Composites with Block Copolymer-Templated Iron Oxide Nanoparticles for Magnetic Hyperthermia Application

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In recent years, nanoparticle hyperthermia has been demonstrated to enhance wave energy absorption (laser photothermal therapy and ultrasound) and to confine energy generation (magnetic nanoparticle hyperthermia) in tumors to minimize collateral tissue damage. In magnetic nanoparticle hyperthermia, magnetic nanoparticles delivered to the tumor site can generate heat when subject to an alternating magnetic field [1][2][3][4][5]. Once the nanoparticles are manufactured, the induced volumetric heat generation rate subject to a specific magnetic field and thermal dosage required to damage the tumor are primarily dependent on the concentration distribution of nanoparticles in the tumor.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Redistribution in PC3 Tumors Induced by Local Heating in Magnetic Nanoparticle Hyperthermia: In Vivo Experimental Study

Joglekar

Bieberich

et al. 2019

Journal of Heat Transfer

Self Cite

View full text Add to dashboard Cite

In magnetic nanoparticle hyperthermia, a required thermal dosage for tumor destruction greatly depends on nanoparticle distribution in tumors. The objective of this study is to conduct in vivo experiments to evaluate whether local heating using magnetic nanoparticle hyperthermia changes nanoparticle concentration distribution in prostatic cancer (PC3) tumors. In vivo animal experiments were performed on grafted PC3 tumors implanted in mice to investigate whether local heating via exposing the tumor to an alternating magnetic field (5 kA/m and 192 kHz) for 25 min resulted in nanoparticle spreading from the intratumoral injection site to tumor periphery. Nanoparticle redistribution due to local heating is evaluated via comparing microCT images of resected tumors after heating to those in the control group without heating. A previously determined calibration relationship between microCT Hounsfield unit (HU) values and local nanoparticle concentrations in the tumors was used to determine the distribution of volumetric heat generation rate (q‴MNH) when the nanoparticles were subject to the alternating magnetic field. sas,matlab, and excel were used to process the scanned data to determine the total heat generation rate and the nanoparticle distribution volumes in individual HU ranges. Compared to the tumors in the control group, nanoparticles in the tumors in the heating group occupied not only the vicinity of the injection site, but also tumor periphery. The nanoparticle distribution volume in the high q‴MNH range (>1.8 × 106 W/m3) is 10% smaller in the heating group, while in the low q‴MNH range of 0.6–1.8 × 106 W/m3, it is 95% larger in the heating group. Based on the calculated heat generation rate in individual HU ranges, the percentage in the HU range larger than 2000 decreases significantly from 46% in the control group to 32% in the heating group, while the percentages in the HU ranges of 500–1000 and 1000–1500 in the heating group are much higher than that in the control group. Heating PC3 tumors for 25 min resulted in significant nanoparticle migration from high concentration regions to low concentration regions in the tumors. The volumetric heat generation rate distribution based on nanoparticle distribution before or after local heating can be used in the future to guide simulation of nanoparticle redistribution and its induced temperature rise in PC3 tumors during magnetic nanoparticle hyperthermia, therefore, accurately predicting required thermal dosage for safe and effective thermal therapy.

show abstract

“…Currently, two nanotechnology-based products are approved for the treatment of cancer, e.g., Doxil (liposomal doxorubicin) and Abraxane (nanoparticle formulated paclitaxel). Novel cancer therapeutics ranging from tiny carbon nanotubes and polymeric nanoparticles to large-scale thermal therapies such as magnetic nanoparticle-based hyperthermia [287,288]. This field of research is growing rapidly with approximately 150 drugs currently in development that incorporate nanotechnology.…”

Section: Experimental Therapies 41 Nanooncologymentioning

confidence: 99%

Innovations in Metastatic Brain Tumor Treatment

Stewart¹,

Stewart²,

Ware³

2020

Brain and Spinal Tumors - Primary and Secondary

View full text Add to dashboard Cite

Metastatic brain tumors (MBTs) are the most common intracranial tumor and occur in up to 40% of patients with certain cancer diagnoses. The most common and frequent primary locations are cancers originating from the lung, breast, kidney, gastrointestinal tract or skin, and also may arising from any part of the body. Treatment for brain metastasis management includes surgery, whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), and chemotherapy. Standard treatment for MBTs includes surgery and SRS which offer the best outcomes, while the WBRT is still an important treatment option for patients who cannot tolerate surgery and SRS or patients with multiple brain metastases. Newer approaches such as immunotherapy and molecularly targeted therapy (e.g., small molecules and monoclonal antibodies) are currently being evaluated for the treatment of MBTs. In this chapter, we will review current available treatments for MBTs and discuss treatments that are undergoing active investigation.

show abstract

Magnetic Nanoparticle Hyperthermia in Cancer Treatment: History, Mechanism, Imaging‐Assisted Protocol Design, and Challenges

Cited by 20 publications

References 142 publications

Electroactive Composites with Block Copolymer-Templated Iron Oxide Nanoparticles for Magnetic Hyperthermia Application

Electroactive Composites with Block Copolymer-Templated Iron Oxide Nanoparticles for Magnetic Hyperthermia Application

Nanoparticle Redistribution in PC3 Tumors Induced by Local Heating in Magnetic Nanoparticle Hyperthermia: In Vivo Experimental Study

Innovations in Metastatic Brain Tumor Treatment

Contact Info

Product

Resources

About