Innovations in Metastatic Brain Tumor Treatment

Stewart, Caleb; Stewart, Brody; Ware, Marcus L.

doi:10.5772/intechopen.86047

Cited by 2 publications

(2 citation statements)

References 301 publications

(250 reference statements)

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“…The surgical elimination of the tumor is dependent on the glioma sub-type and its location within the brain [6]. However, although additional chemotherapy and radiotherapy can prolong median survival up to more than 1 year, tumor cells still develop resistance mechanisms to these therapies [8][9][10]. Identifying the detailed molecular mechanisms involved in tumor progression could reveal novel approaches to developing more effective therapies.…”

Section: Introductionmentioning

confidence: 99%

Autophagy in cancers including brain tumors: role of MicroRNAs

et al. 2020

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Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate the process of autophagy. Recently miRNAs (small noncoding RNAs) have been found to play a vital role in the regulation of different cellular and molecular processes, such as autophagy. Deregulation of these molecules is associated with the development and progression of different pathological conditions, including brain tumors. It was found that miRNAs are epigenetic regulators, which influence the level of proteins coded by the targeted mRNAs with any modification of the genetic sequences. It has been revealed that various miRNAs (e.g., miR-7-1-3p, miR-340, miR-17, miR-30a, miR-224-3p, and miR-93), as epigenetic regulators, can modulate autophagy pathways within brain tumors. A deeper understanding of the underlying molecular targets of miRNAs, and their function in autophagy pathways could contribute to the development of new treatment methods for patients with brain tumors. In this review, we summarize the various miRNAs, which are involved in regulating autophagy in brain tumors. Moreover, we highlight the role of miRNAs in autophagy-related pathways in different cancers.

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Section: Introductionmentioning

confidence: 99%

Autophagy in cancers including brain tumors: role of MicroRNAs

et al. 2020

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“…The notion depicted in the quote above—that workplace exhaustion is a never-ending cycle—is widely discussed in the popular press. Indeed, a recent article touted the importance of “Breaking the Cycle of Exhaustion” in health care (Stewart, 2021), and one manager reported, “the stress of the day may weigh on her and…the next day, she will come in…even more tired than before, and the cycle will continue” (Fica, 2017, para. 12).…”

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confidence: 99%

Examining regulatory focus in the acceleration and deceleration of engagement and exhaustion cycles among nurses

Paustian‐Underdahl

Halbesleben

Carlson

et al. 2023

Health Care Manage Rev

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BackgroundGiven that emotional exhaustion and nurse engagement have significant implications for nurse well-being and organizational performance, determining how to increase nurse engagement while reducing nurse exhaustion is of value.PurposeResource loss and gain cycles, as theorized in conservation of resources theory, are examined using the experience of emotional exhaustion to evaluate loss cycles and work engagement to evaluate gain cycles. Furthermore, we integrate conservation of resources theory with regulatory focus theory to examine how the ways in which individuals approach work goals serves as a facilitator to the acceleration and deceleration of both of these cycles.Methodology/ApproachUsing data from nurses working in a hospital in the Midwest United States at six time points spanning over 2 years, we demonstrate the accumulation effects of the cycles over time using latent change score modeling.ResultsWe found that prevention focus was associated with the accelerated accumulation effects of emotional exhaustion and that promotion focus was associated with the accelerated accumulation effects of work engagement. Furthermore, prevention focus attenuated the acceleration of engagement, but promotion did not influence the acceleration of exhaustion.ConclusionOur findings suggest that individual factors such as regulatory focus are key to helping nurses to better control their resource gain and loss cycles.Practice ImplicationsWe provide implications for nurse managers and health care administrators to help encourage promotion focus and suppress prevention focus in the workplace.

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Innovations in Metastatic Brain Tumor Treatment

Cited by 2 publications

References 301 publications

Autophagy in cancers including brain tumors: role of MicroRNAs

Autophagy in cancers including brain tumors: role of MicroRNAs

Examining regulatory focus in the acceleration and deceleration of engagement and exhaustion cycles among nurses

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