Electroactive Composites with Block Copolymer-Templated Iron Oxide Nanoparticles for Magnetic Hyperthermia Application

Abstract

Cancer has been one of the leading causes of human death for centuries. Magnetic hyperthermia is a promising technique to confine and control cancers. However, particles used in magnetic hyperthermia leaking from where the cancers are located could compromise human health. Therefore, we developed electroactive iron oxide/block copolymer composites to tackle the leakage problem. Experimental results show that oleylamine-modified magnetic iron oxide (Fe3O4) particles and electroactive tetraaniline (TA) could be templated in the self-assembled microstructures of sulfonated [styrene-b-(ethylene-ran-butylene)-b-styrene] (S-SEBS) block copolymers. Various amounts of Fe3O4 particles and TA oligomer were incorporated in S-SEBS block copolymer and their electroactive behavior was confirmed by exhibiting two pairs of well-defined anodic and cathodic current peaks in cyclic voltammetry tests. The heating performance of the resultant TA/Fe3O4/polymer composites improved on increasing the added amount of Fe3O4 particles and TA oligomers. Both Fe3O4 and TA can contribute to improved heating performance, but Fe3O4 possesses a greater contribution than TA does. Hence, the main source for increasing the composites’ temperature is Neel relaxation loss from Fe3O4 magnetic particles.

Upcycling of Polybenzoxazine to Magnetic Metal Nanoparticle-Doped Laser-Induced Graphene for Electromagnetic Interference Shielding

“…The SAR value of the LIG/Fe 3 O 4 -4 is calculated to be around 1.15 W/g. This value compares well or it is superior to the ones reported for manganese ferrite (0.14 W/ g), 74 polymer/Fe 3 O 4 composites (0.3−1.1 W/g), 75 or graphene/Fe 3 O 4 hybrids (1.8−6.5 W/g). 76 Similarly, the LIG/ FeCo sample, which has stronger magnetic properties, also displays significant magnetic-to-thermal conversion (Figure S18).…”

Electroactive aniline tetramer–spider silks with conductive and electrochromic functionality

“…Aniline tetramer was prepared using the procedure reported in literature. 23,24 N -Phenyl- p -phenylenediamine (2 g) was dissolved in 200 mL of 1 N hydrochloric acid (HCl) and kept its temperature at 0 °C. Subsequently, a solution of ferric chloride hexahydrate (4.9 g in 30 mL of 1 N HCl) was added into the prepared N -phenyl- p -phenylenediamine solution.…”

Long non-coding RNAs in lung cancer: implications for lineage plasticity-mediated TKI resistance

“…Since certain epigenetic alterations are correlated with slow-cycling drug-tolerant cells, targeting the potential epigenetic regulators serves as an important way to ameliorate lineage plasticity. Notably, preventing phenotypic switching by targeting HDAC or histone demethylases KDM5A/B and KDM6A/B have promising results in early-phase studies [ 120 ]. In NSCLC, trimethylation of lysine 9 on histone (H3K9me3) represses long-interspersed repeat elements 1 (LINE-1), thus inhibiting the expression of interferon and antiviral-activated genes to promote EGFR TKI-tolerant cell survival [ 121 , 122 ].…”