Magnetic nanoparticle-based drug delivery for cancer therapy

Tietze, Rainer; Zaloga, Jan; Unterweger, Harald; Lyer, Stefan; Friedrich, Ralf P.; Janko, Christina; Pöttler, Marina; Dürr, Stephan; Alexiou, Christoph

doi:10.1016/j.bbrc.2015.08.022

Cited by 365 publications

(174 citation statements)

References 63 publications

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“…Multimodal magnetic nanoparticles have long been the subject of investigation for use as drug delivery vehicles, and many strategies for their synthesis, drug loading and release have been examined [67]. However, comparatively, few comprehensive studies on magnetic-plasmonic based drug delivery systems have been carried out, despite many potential theranostic applications which these systems would have.…”

Section: Drug Delivery and Targetingmentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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Magnetic plasmonic nanomaterials are of great interest in the field of biomedicine due to their vast number of potential applications, for example, in molecular imaging, photothermal therapy, magnetic hyperthermia and as drug delivery vehicles. The multimodal nature of these nanoparticles means that they are potentially ideal theranostic agents-i.e., they can be used both as therapeutic and diagnostic tools. This review details progress in the field of magnetic-plasmonic nanomaterials over the past ten years, focusing on significant developments that have been made and outlining the future work that still needs to be done in this fast emerging area. The review describes the main synthetic approaches to each type of magnetic plasmonic nanomaterial and the potential biomedical applications of these hybrid nanomaterials.

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Section: Drug Delivery and Targetingmentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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“…Using SPIONs, hyperthermia of tumor-accumulated particles in the presence of an external alternating magnetic field or magnetic drug targeting (MDT) after SPION conjugation with chemotherapeutic drugs has been reported. 8,[12][13][14][15][16][17] Additionally, by combining imaging and therapy, SPIONs have the potential to serve as theranostics. 18 Despite numerous published research papers describing promising nanoparticles for medical applications, only very few nanoparticle types have been translated into the clinics to date.…”

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confidence: 99%

Selection of potential iron oxide nanoparticles for breast cancer treatment based on in vitro cytotoxicity and cellular uptake

Poller¹,

Zaloga²,

Schreiber³

et al. 2017

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) are promising tools for the treatment of different diseases. Their magnetic properties enable therapies involving magnetic drug targeting (MDT), hyperthermia or imaging. Depending on the intended treatment, specific characteristics of SPIONs are required. While particles used for imaging should circulate for extended periods of time in the vascular system, SPIONs intended for MDT or hyperthermia should be accumulated in the target area to come into close proximity of, or to be incorporated into, specific tumor cells. In this study, we determined the impact of several accurately characterized SPION types varying in size, zeta potential and surface coating on various human breast cancer cell lines and endothelial cells to identify the most suitable particle for future breast cancer therapy. We analyzed cellular SPION uptake, magnetic properties, cell proliferation and toxicity using atomic emission spectroscopy, magnetic susceptometry, flow cytometry and microscopy. The results demonstrated that treatment with dextran-coated SPIONs (SPION Dex ) and lauric acid-coated SPIONs (SPION LA ) with an additional protein corona formed by human serum albumin (SPION LA-HSA ) resulted in very moderate particle uptake and low cytotoxicity, whereas SPION LA had in part much stronger effects on cellular uptake and cellular toxicity. In summary, our data show significant dose-dependent and particle type-related response differences between various breast cancer and endothelial cells, indicating the utility of these particle types for distinct medical applications.

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“…The main advantage of this vehicles is the availability of relatively simple chemical pathways to conjugate biocompatible polymers, which in turn can be further functionalized with therapeutic agents [2]. Additionally, nanoparticles offer large surface-to-volume ratios, and exhibit sizes similar to those of various biological molecules including antibodies, receptors and nucleic acids [3]. Consequently, nanoparticles are well suited to pass through highly-selective biological tissues such as the blood-brain barrier (BBB), which consists of tight junctions that confer selectivity towards water, some gases and lipid-soluble molecules [4] [5].…”

Section: Introductionmentioning

confidence: 98%

Permanent Magnets to Enable Highly-Targeted Drug Delivery Applications: A Computational and Experimental Study

Mercado-M

Cruz

2017

VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

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Abstract-Nanoparticle-based therapies have gained considerable attention over the past few years as potential candidates for the development of robust treatments for degenerative conditions such as Parkinson's or Alzheimer's. A major challenge to increase the specificity of such therapies is the limited control over their fate and transport upon administration. An avenue to overcome this issue is to immobilize the therapeutic molecules on magnetically responsive nanostructures. This allows a direct control via magnetic fields generated through either permanent or electromagnets. Permanent magnets offer technical and economic advantages over electromagnets but their spatial disposition needs to be dynamically adjusted to assure proper magnetic gradient directionality. The engineering of such a dynamic system requires a detailed understanding of the impact of changing the number and relative positions of magnets in close proximity to the particles, which can be tedious to achieve experimentally. Alternatively, electromagnetic modeling and simulation provides a rather expedite route to explore multiple configurations. Here we evaluate, against experimental data, the robustness of electromagnetic models incorporated in the software COMSOL® to predict field gradients and intensities. We tested two of the incorporated meshing approaches in a single magnet and an array of two magnets. Our findings indicate that the two approaches fitted the experimental data as evidenced by the statistical significance of various correlation indexes.

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Magnetic nanoparticle-based drug delivery for cancer therapy

Cited by 365 publications

References 63 publications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Selection of potential iron oxide nanoparticles for breast cancer treatment based on in vitro cytotoxicity and cellular uptake

Permanent Magnets to Enable Highly-Targeted Drug Delivery Applications: A Computational and Experimental Study

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